Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

The COVID-19 Forecast Hub
The COVID-19 Forecast Hub, August 2020

This site maintains the authoritative, up-to-date record for forecasts of COVID-19 deaths and hospitalizations in the US, created by dozens of leading infectious disease modeling teams from around the globe, in coordination with CDC.

Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing
WE Allen et al, Nature Human Behavior, August 26, 2020

We developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behavior and demographics. Here, we report results from over 500,000 users in the United States. We show that self-reported surveys can be used to build predictive models to identify likely COVID-19-positive individuals.

Sex differences in immune responses that underlie COVID-19 disease outcomes
T Takahashi et al, Nature, August 26, 2020

Male patients had higher plasma levels of innate immune cytokines such as IL-8 and IL-18 along with more robust induction of non-classical monocytes. Female patients mounted significantly more robust T cell activation than male patients during SARS-CoV-2 infection. Importantly, we found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.

Two metres or one: what is the evidence for physical distancing in covid-19?
NR Jones et al, BMJ, August 25, 2020

Instead of single, fixed physical distance rules, we propose graded recommendations that better reflect the multiple factors that combine to determine risk. This would provide greater protection in the highest risk settings but also greater freedom in lower risk settings, potentially enabling a return towards normality in some aspects of social and economic life.

Changes in mobility patterns in Europe during the COVID-19 pandemic: Novel insights using open source data
AS Islind et al. ARXIV, August 24, 2020

Blockchain-enabled Internet of Medical Things to Combat COVID-19
HN Dai et al, ARXIV, August 23, 2020

Disparities [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 29, 2020

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• Revisiting Health Care System Data Priorities to Improve Population Health and Address Inequity
  CC Kenyon et al, JAMA Health Forum, August 28 2020
• US racial inequality may be as deadly as COVID-19.
  Wrigley-Field Elizabeth et al. Proceedings of the National Academy of Sciences of the United States of America 2020 Aug
• Hidden in Plain Sight — Reconsidering the Use of Race Correction in Clinical Algorithms
  DA Vyas et al, NEJM, August 27, 2020
• Willingness to Participate in Health Research Among Community-Dwelling Middle-Aged and Older Adults: Does Race/Ethnicity Matter?
  Milani Sadaf Arefi et al. Journal of racial and ethnic health disparities 2020 Aug
• Alaska Native genomic research: perspectives from Alaska Native leaders, federal staff, and biomedical researchers.
  Hiratsuka Vanessa Y et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug
• Predictably unequal: understanding and addressing concerns that algorithmic clinical prediction may increase health disparities.
  Paulus Jessica K et al. NPJ digital medicine 2020 399
• Health Disparities and COVID-19: A Retrospective Study Examining Individual and Community Factors Causing Disproportionate COVID-19 Outcomes in Cook County, Illinois, March 16-May 31, 2020
  L Unruh et al, MEDRXIV, August 24, 2020
• Bias at Warp Speed: How AI may Contribute to the Disparities Gap in the Time of COVID-19.
  Röösli Eliane et al. Journal of the American Medical Informatics Association : JAMIA 2020 Aug
• Race Disparities in the COVID-19 Pandemic—Solutions Lie in Policy, Not Biology
  LE Boulware, JAMA Network Open, AUgust 18, 2020
• Disparities in Incidence of COVID-19 Among Underrepresented Racial/Ethnic Groups in Counties Identified as Hotspots During June 5–18, 2020 — 22 States, February–June 2020
  JT Moore et al, CDC MMWR, August 14, 2020

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Real stories [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 26, 2020

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• “My disability has become an ability”
  E Manna, Nature Medicine, August 24, 2020
• Real Stories: Living with Spina Bifida
  CDC, 2019
• How I wish people talked about living with a BRCA mutation
  E Stallings, Hello Giggles, June 26, 2019
• When a Rare Mutation Causes a Rare Disease: Jacob’s Story
  R Lewis, PLOS Blogs, June 20, 2019
• When a Rare Mutation Causes a Rare Disease: Jacob�s Story
  R Lewis, PLOS Blogs, June 20, 2019
• 'Out of the Blue' Diagnosis Linked to a Family History of Cancer Now Empowers Others
  S Friedman, Cure, June 12, 2019
• 7 Things I Wish I Had Known About Being 'Rare'
  K Moore, The Mighty, March 2019
• Avery Watts and family fighting for her heart
  J Heim, HM Media, March, 2019
• Real Stories from People Living with Hemophilia
  CDC, 2019
• I Got A Double Mastectomy After A Genetic Test. Then I Learned The Results Were Wrong.
  M Boesen, Huffington Post, February 22, 2019

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Developmental disabilities [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 30, 2020

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• People with intellectual and developmental disabilities disproportionately affected by COVID-19
  NIH, August 28, 2020
• The value of genomic sequencing in complex pediatric neurological disorders: a discrete choice experiment.
  Goranitis Ilias et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug
• A preliminary evaluation of still face images by deep learning: A potential screening test for childhood developmental disabilities.
  Yang You et al. Medical hypotheses 2020 Jun 144109978
• Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis.
  Turk Margaret A et al. Disability and health journal 2020 May 100942
• Chromosomal Aberrations in Pediatric Patients with Developmental Delay/Intellectual Disability: A Single-Center Clinical Investigation.
  Hu Ting et al. BioMed research international 2019 20199352581
• Perceived utility of biological testing for autism spectrum disorder is associated with child and family functioning.
  Yusuf Afiqah et al. Research in developmental disabilities 2020 Feb 100103605
• Association of Genetic Risks With Autism Spectrum Disorder and Early Neurodevelopmental Delays Among Children Without Intellectual Disability.
  Takahashi Nagahide et al. JAMA network open 2020 Feb 3(2) e1921644
• Helping Children Live to the Fullest by Understanding Developmental Disabilities,
  National Center on Birth Defects and Developmental Disabilities (NCBDDD), CDC
• Saving Babies Through Surveillance, Research, and Prevention of Birth Defects and Infant Disorders,
  National Center on Birth Defects and Developmental Disabilities (NCBDDD), CDC
• "Just tell me what's going on": The views of parents of children with genetic conditions regarding the research use of their child's electronic health record.
  Andrews Sara M et al. Journal of the American Medical Informatics Association : JAMIA 2020 Jan

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Cancer Genomics - Cancer PHGKB -

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What's New

Last Posted: Aug 31, 2020

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• External Evaluation of 3 Commercial Artificial Intelligence Algorithms for Independent Assessment of Screening Mammograms 
  JM Salim et al, JAMA Oncology, August 27, 2020
• Genetic Disease Risk Impacted by Entire Genome, Study Reveals 
  J Kent, Health Analytics, August 27, 2020
• Tailoring Intensity of Active Surveillance for Low-Risk Prostate Cancer Based on Individualized Prediction of Risk Stability. 
  Cooperberg Matthew R et al. JAMA oncology 2020 Aug e203187
• Artificial intelligence in radiation oncology 
  E Huynh et al, Nature Rev Clin Oncol, August 25, 2020
• Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors 
  L Zhang et al, JAMA Network Open, August 26, 2020
• Efficacy of Selpercatinib in RET -Altered Thyroid Cancers. 
  Wirth Lori J et al. The New England journal of medicine 2020 Aug (9) 825-835
• Selpercatinib Aimed at RET -Altered Cancers. 
  Kurzrock Razelle et al. The New England journal of medicine 2020 Aug (9) 868-869
• Comparative analysis of racial differences in breast tumor microbiome 
  S Tyagarajan et al, SCi Rep, August 24, 2020
• Development of a Machine Learning Model for Survival Risk Stratification of Patients With Advanced Oral Cancer 
  YJ Tseng et al, JAMA Network Open, August 21, 2020
• LIVING WITH LYNCH 2020- Virtual Patient Workshop 
  Alive and Kicking and Colon Cancer Foundation Webinar October 9, 2020
• Molecules in the blood of older people promote cancer spread 
  H Wang et al, Nature News, August 19, 2020
• Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions 
  AC Fahed et al, Nature Communications, August 20, 2020
• Extremely high birth prevalence of sickle cell disease in rural Tanzania. 
  Eastburg Luke et al. Pediatric blood & cancer 2020 Aug e28620
• Molecular Assays to Determine Optimal Duration of Adjuvant Endocrine Therapy in Breast Cancer. 
  Anandan Apoorva et al. Current treatment options in oncology 2020 Aug 21(10) 84
• Natural Language Processing of Serum Protein Electrophoresis Reports in the Veterans Affairs Health Care System. 
  Ryu Justine H et al. JCO clinical cancer informatics 2020 Aug 4749-756

Thyroid cancer [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 28, 2020

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• Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review.
  McKelvey Brittany A et al. Frontiers in endocrinology 2020 11485
• Efficacy of Selpercatinib in RET -Altered Thyroid Cancers.
  Wirth Lori J et al. The New England journal of medicine 2020 Aug (9) 825-835
• Highly Sensitive and Specific Molecular Test for Mutations in the Diagnosis of Thyroid Nodules: A Prospective Study of BRAF -Prevalent Population.
  Cho Yoon Young et al. International journal of molecular sciences 2020 Aug 21(16)
• Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?
  Muallem Kalmovich Limor et al. The Laryngoscope 2020 Aug
• Molecular Profiling of Thyroid Nodules—Are These Findings Meaningful, or Merely Measurable?
  LGT Morris, JAMA Oto Larnyg, July 30, 2020
• Automated thyroid nodule detection from ultrasound imaging using deep convolutional neural networks.
  Abdolali Fatemeh et al. Computers in biology and medicine 2020 Jul 122103871
• Should Total Thyroidectomy Be Recommended for Patients with Familial Non-medullary Thyroid Cancer?
  Kim Yon Seon et al. World journal of surgery 2020 Jun
• Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.
  Qin Na et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Jun JCO1902760
• Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics.
  Yim John H et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2019 25(2) 544-551
• A primer on the genetics of medullary thyroid cancer.
  Larouche V et al. Current oncology (Toronto, Ont.) 2019 Dec 26(6) 389-394

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Diabetes [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 28, 2020

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• Latest Advancements in Artificial Intelligence-Enabled Technologies in Treating Type 1 Diabetes.
  Qian Feng et al. Journal of diabetes science and technology 2020 Aug 1932296820949940
• Machine Learning based Early Prediction of End-stage Renal Disease in Patients with Diabetic Kidney Disease using Clinical Trials Data.
  Belur Nagaraj Sunil et al. Diabetes, obesity & metabolism 2020 Aug
• Machine learning risk score for prediction of gestational diabetes in early pregnancy in Tianjin, China.
  Liu Hongwei et al. Diabetes/metabolism research and reviews 2020 Aug e3397
• A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.
  Breton Marc D et al. The New England journal of medicine 2020 Aug (9) 836-845
• Identification of risk factors for patients with diabetes: diabetic polyneuropathy case study.
  Metsker Oleg et al. BMC medical informatics and decision making 2020 Aug 20(1) 201
• Wound assessment, imaging and monitoring systems in diabetic foot ulcers: A systematic review.
  Chan Kai Siang et al. International wound journal 2020 Aug
• A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care.
  Sharp Seth A et al. Alimentary pharmacology & therapeutics 2020 Aug
• A digital biomarker of diabetes from smartphone-based vascular signals
  R Avram et al, Nature Medicine, August 17, 2020
• A Novel and Precise Profiling Tool to Predict Gestational Diabetes.
  McLaren Rodney et al. Journal of diabetes science and technology 2020 Aug 1932296820948883
• A Novel Approach for Continuous Health Status Monitoring and Automatic Detection of Infection Incidences in People With Type 1 Diabetes Using Machine Learning Algorithms (Part 2): A Personalized Digital Infectious Disease Detection Mechanism.
  Woldaregay Ashenafi Zebene et al. Journal of medical Internet research 2020 Aug 22(8) e18912

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Immunotherapy [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 27, 2020

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• Association of MUC16 Mutation With Response to Immune Checkpoint Inhibitors in Solid Tumors
  L Zhang et al, JAMA Network Open, August 26, 2020
• Identification of Hepatocellular Carcinoma prognostic markers based on 10-immune gene signature.
  Zhao Kaifei et al. Bioscience reports 2020 Aug
• Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer.
  Lu Zhihao et al. Journal for immunotherapy of cancer 2020 Aug 8(2)
• A prognostic signature based on immune-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma.
  Liu Jinhui et al. International immunopharmacology 2020 Aug 88106884
• A robust signature associated with patient prognosis and tumor immune microenvironment based on immune-related genes in lung squamous cell carcinoma.
  Zhou Hao et al. International immunopharmacology 2020 Aug 88106856
• Analysis of prognostic genes in the tumor microenvironment of lung adenocarcinoma.
  Xu Zhan-Yu et al. PeerJ 2020 8e9530
• Tumor mutation burden in Chinese cancer patients and the underlying driving pathways of high tumor mutation burden across different cancer types.
  Jiao Xiao-Dong et al. Annals of translational medicine 2020 Jul 8(14) 860
• A novel risk score based on a combined signature of 10 immune system genes to predict bladder cancer prognosis.
  Tang Yunliang et al. International immunopharmacology 2020 Aug 87106851
• Mismatch Repair Protein Deficiency/Microsatellite Instability Is Rare in Cholangiocarcinomas and Associated With Distinctive Morphologies.
  Ju Jennifer Y et al. American journal of clinical pathology 2020 153(5) 598-604
• Tumor mutational burden quantification from targeted gene panels: major advancements and challenges.
  Fancello Laura et al. Journal for immunotherapy of cancer 2019 7(1) 183

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Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

Bridging digital health divides
A Agrawal, Science, August 28, 2020

The COVID-19 pandemic has accelerated digital health implementation in India and elsewhere, such as this telemedicine hub in New Delhi, expanding the reach of health care.

Emerging Pandemic Diseases: How We Got to COVID-19.
Morens David M et al. Cell 2020 Aug

Disease emergence reflects dynamic balances and imbalances, within complex globally distributed ecosystems comprising humans, animals, pathogens, and the environment. Understanding these variables is a necessary step in controlling future devastating disease emergences.

A New Mathematical Model for Controlled Pandemics Like COVID-19 : AI Implemented Predictions
LD Jones et al ARXIV, AUgust 24, 2020

Machine Reasoning to Assess Pandemics Risks: Case of USS Theodore Roosevelt
K Lai et al, ARXIV, August 24, 2020

Data Mining Approach to Analyze Covid19 Dataset of Brazilian Patients
JE Chire Saire, ARXIV, August 26, 2020

DeepSOCIAL: Social Distancing Monitoring and Infection Risk Assessment in COVID-19 Pandemic
M Rezaei et al, ARXIV, August 26, 2020

Global and Local Mutations in Bangladeshi SARS-CoV-2 Genomes
MM Hasan et al, BIORXIV, August 26, 2020

https://www.medrxiv.org/content/10.1101/2020.08.24.20181008v1
F Volpato et al, MEDRXIV, August 26, 2020

Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

The coronavirus is most deadly if you are older and male — new data reveal the risks
S Mallapaty, Nature News, August 28, 2020

For every 1,000 people infected with the coronavirus who are under the age of 50, almost none will die. For people in their fifties and early sixties, about five will die — more men than women. The risk then climbs steeply as the years accrue. For every 1,000 people in their mid-seventies or older who are infected, around 116 will die.

Prevention of endothelial dysfunction and thrombotic events in COVID-19 patients with familial hypercholesterolemia.
Vuorio Alpo et al. Journal of clinical lipidology 2020 Jun

Development and evaluation of a rapid CRISPR-based diagnostic for COVID-19.
Hou Tieying et al. PLoS pathogens 2020 Aug (8) e1008705

We developed a rapid and sensitive diagnostic for SARS-CoV-2 infection, and compared it to sequencing-based metagenomic and RT-PCR-based assays in a clinical cohort. The test demonstrated a sensitivity level of near single copy and was highly specific without cross reacting to related pathogens. It takes only 40 mins and provides a valuable alternative to the conventional RT–PCR assay to circumvent the bottlenecks in assay turnaround time.

People with Moderate to Severe Asthma
CDC, August 2020 

People with moderate to severe asthma may be at higher risk of getting very sick from COVID-19. COVID-19 can affect your nose, throat, lungs (respiratory tract); cause an asthma attack; and possibly lead to pneumonia and acute respiratory disease.

Data on COVID-19 during Pregnancy
CDC, August 2020 

A recent study suggests that pregnant women with COVID-19 are more likely to be hospitalized and are at increased risk for intensive care unit (ICU) admission and receipt of mechanical ventilation than nonpregnant women. Risk of death is similar for both groups. But much remains unknown.

Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers
N Shental et al, Science Advances, August 2020

We developed P-BEST - a method for Pooling-Based Efficient SARS-CoV-2 Testing which identifies all positive subjects within a large set of samples using a single round of testing. Each sample is assigned into multiple pools using a combinatorial pooling strategy based on compressed sensing designed for maximizing carrier detection.

For Quick Coronavirus Testing, Israel Turns to a Clever Algorithm
DM Halbfinger, NY Times, August 27, 2020

Inspired by a mother’s question, the new method will be introduced across Israel this fall, just in time for flu season, and could be coming soon to the U.S.

Pharmacogenomics [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 28, 2020

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• CYP2C19 Genotyping to Guide Antiplatelet Therapy After Percutaneous Coronary Interventions: One Size Rarely Fits All.
  Moliterno David J et al. JAMA 2020 08 (8) 747-749
• Pediatric pharmacogenomics: challenges and opportunities: on behalf of the Sanford Children’s Genomic Medicine Consortium
  D Gregornik et al, Pharmacogenetics Journal, August 26, 2020
• Pharmacogenetics in clinical practice: current level of knowledge among Flemish physicians and pharmacists.
  Edris Ahmed et al. The pharmacogenomics journal 2020 Aug
• Clinical Utility of CYP2C19 Genotype-Guided Antiplatelet Therapy in Patients at Risk of Adverse Cardiovascular and Cerebrovascular Events: A Review of Emerging Evidence.
  Gower Megan N et al. Pharmacogenomics and personalized medicine 2020 13239-252
• Identification of high-impact gene-drug pairs for pharmacogenetic testing in Alberta, Canada.
  Fan Mikayla et al. Pharmacogenetics and genomics 2020 Aug
• Data Integration Using Advances in Machine Learning in Drug Discovery and Molecular Biology.
  Hudson Irene Lena et al. Methods in molecular biology (Clifton, N.J.) 2021 2190167-184
• Pharmacogenomics Instruction Depth, Extent, and Perception in US Medical Curricula.
  Basyouni Dara et al. Journal of medical education and curricular development 72382120520930772
• Pharmacogenomics of COVID-19 therapies
  T Takahashi et al, NPJ Genomic Medicine, August 18, 2020
• Description of Pharmacogenomic Testing Among Patients Admitted to the Intensive Care Unit After Cardiovascular Surgery.
  Peterson Pamela E et al. Journal of intensive care medicine 2020 Jul 885066620946303
• Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network.
  Duong Benjamin Q et al. Pharmacogenomics and personalized medicine 2020 13217-226

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Newborn screening [NEW TOPIC PAGE]

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Last Posted: Aug 28, 2020

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• Genomic Sequencing for Newborn Screening: Results of the NC NEXUS Project.
  Roman Tamara S et al. American journal of human genetics 2020 Aug
• A Comparative Effectiveness Study of Newborn Screening Methods for Four Lysosomal Storage Disorders.
  Sanders Karen A et al. International journal of neonatal screening 2020 Jun 6(2)
• Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening.
  Allaf Bichr et al. Clinical chemistry and laboratory medicine 2020 Aug
• Cystic fibrosis in low and middle-income countries (LMIC): A view from four different regions of the world.
  da Silva Filho Luiz Vicente Ribeiro Ferreira et al. Paediatric respiratory reviews 2020 Jul
• Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing.
  Adhikari Aashish N et al. International journal of neonatal screening 2020 Jun 6(2)
• Highlights on Genomics Applications for Lysosomal Storage Diseases.
  La Cognata Valentina et al. Cells 2020 Aug 9(8)
• Newborn Screening Protocols and Positive Predictive Value for Congenital Adrenal Hyperplasia Vary across the United States.
  Speiser Phyllis W et al. International journal of neonatal screening 2020 Jun 6(2)
• Vulnerable Child Syndrome and Newborn Screening Carrier Results for Cystic Fibrosis or Sickle Cell.
  Farrell Michael H et al. The Journal of pediatrics 2020 Sep 22444-50.e1
• Extremely high birth prevalence of sickle cell disease in rural Tanzania.
  Eastburg Luke et al. Pediatric blood & cancer 2020 Aug e28620
• Cystic Fibrosis-Screening Positive Inconclusive Diagnosis: Newborn Screening and Long-Term Follow-Up Permits to Early Identify Patients with CFTR-Related Disorders.
  Castaldo Alice et al. Diagnostics (Basel, Switzerland) 2020 Aug 10(8)

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Prostate cancer [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB






Last Posted: Aug 28, 2020

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• Tailoring Intensity of Active Surveillance for Low-Risk Prostate Cancer Based on Individualized Prediction of Risk Stability.
  Cooperberg Matthew R et al. JAMA oncology 2020 Aug e203187
• Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank.
  Wei Jun et al. British journal of cancer 2020 Aug
• A 10-gene signature as a predictor of biochemical recurrence after radical prostatectomy in patients with prostate cancer and a Gleason score ≥7.
  Wu Xiangkun et al. Oncology letters 2020 Sep 20(3) 2906-2918
• MiR-93/miR-375: Diagnostic Potential, Aggressiveness Correlation and Common Target Genes in Prostate Cancer.
  Ciszkowicz Ewa et al. International journal of molecular sciences 2020 Aug 21(16)
• Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT.
  Handy Whitney F et al. Cancer biology & therapy 2020 Aug 1-3
• Patterns of cancer family history and genetic counseling eligibility among African Americans with breast, prostate, lung, and colorectal cancers: A Detroit Research on Cancer Survivors cohort study.
  Purrington Kristen S et al. Cancer 2020 Aug
• Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists.
  Bulten Wouter et al. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 Aug
• Dr. Answer AI for prostate cancer: Clinical outcome prediction model and service.
  Rho Mi Jung et al. PloS one 2020 15(8) e0236553
• Multicenter Multireader Evaluation of an Artificial Intelligence-Based Attention Mapping System for the Detection of Prostate Cancer With Multiparametric MRI.
  Mehralivand Sherif et al. AJR. American journal of roentgenology 2020 Aug 1-10
• PSA-based machine learning model improves prostate cancer risk stratification in a screening population.
  Perera Marlon et al. World journal of urology 2020 Aug

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Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Wyllie Anne L et al. The New England journal of medicine 2020 Aug

Given the growing need for testing, our findings provide support for the potential of saliva specimens in the diagnosis of SARS-CoV-2 infection. Collection of saliva samples by patients negates the need for interaction with health care workers, a source of testing bottlenecks. This also alleviates demands for supplies of swabs and personal protective equipment.

Scientists are reporting several cases of Covid-19 reinfection — but the implications are complicated
A Joseph, Stat News, August 28, 2020

Digital health [NEW TOPIC PAGE]

Main|Search|PHGKB




Last Posted: Aug 29, 2020

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• Challenges for the evaluation of digital health solutions—A call for innovative evidence generation approaches
  C Guo et al, NPJ Digital Medicine, August 27, 2020
• The Role of Digital Health Technologies in Drug Development: Proceedings of a Workshop
  NASEM Roundtable on Genomics and Precision Health Workshop, 2020
• The Need for Developing Technology-enabled, Safe and Ethical Workforce for Healthcare Delivery.
  Sarbadhikari S N et al. Safety and health at work 2020 Aug
• Bridging digital health divides
  A Agrawal, Science, August 28, 2020
• Artificial intelligence in medical imaging: switching from radiographic pathological data to clinically meaningful endpoints
  O Oren et al, Lancet Digital Health, September 1, 2020
• From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care.
  Griffin Ashley C et al. Yearbook of medical informatics 2020 Aug 29(1) 235-242
• Regulatory, safety, and privacy concerns of home monitoring technologies during COVID-19
  S Gerke et al, Nature Medicine, August 7, 2020
• Health Policy and Privacy Challenges Associated With Digital Technology
  D Grande et al, JAMA Network Open, August 9, 2020
• Build trust in digital health
  Nature Medicine editorial, August 7, 2020
• Use of electronic tools for evidence-based preparedness and response to the COVID-19 pandemic in the WHO African region
  B Impouma et al Lancet Digital Health, August 7, 2020

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Proteomics [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB




Last Posted: Aug 29, 2020

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• Genetics meets proteomics: perspectives for large population-based studies
  K Suhre et al, Nature Rev Genetics, August 28, 2020
• Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma.
  Han Wei et al. Journal of Cancer 2020 11(17) 5245-5256
• Strategies to enable large-scale proteomics for reproducible research
  RC Poulos et al, Nature Comms, July 30, 2020
• Mass spectrometry-based proteomic techniques to identify cerebrospinal fluid biomarkers for diagnosing suspected central nervous system infections. A systematic review.
  Bharucha Tehmina et al. The Journal of infection 2019 79(5) 407-418
• Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression.
  Komor Malgorzata A et al. The Journal of pathology 2020 250(3) 288-298
• Proteome analysis of non-small cell lung cancer cell line secretomes and patient sputum reveals biofluid biomarker candidates for cisplatin response prediction.
  Böttger Franziska et al. Journal of proteomics 2019 196106-119
• Population Genetics of SARS-CoV-2: Disentangling Effects of Sampling Bias and Infection Clusters.
  Liu Qi et al. Genomics, proteomics & bioinformatics 2020 Jul
• Proteomics and informatics for understanding phases and identifying biomarkers in COVID-19 disease.
  Whetton Anthony D et al. Journal of proteome research 2020 Jul
• Lung Adenocarcinoma (LUAD) Discoveries from two NCI Proteomics Consortia
  NCI, July 9, 2020
• Artificial Intelligence and Hypertension: Recent Advances and Future Outlook.
  Chaikijurajai Thanat et al. American journal of hypertension 2020 Jul

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