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Genomics|Features|Stahylococcus

Staphylococcus Aureus

Methicillin-Resistant Staphylococcus Aureus: Genomic Insights - May 29, 2015

Whole-genome sequencing for outbreak investigations of methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit: time for routine practice?
Azarian T et al. Infect Control Hosp Epidemiol 2015 May 8. 1-9

Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus.
Steinig EJ et al. BMC Genomics 2015 (1) 388

Draft genome sequence of bacillus amyloliquefaciens AP183 with antibacterial activity against Methicillin-resistant Staphylococcus aureus.
Nasrin S et al. Genome Announc 2015 (2)

Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to Vancomycin and Daptomycin, based on determination of the complete genome.
Yamaguchi T et al. Antimicrob. Agents Chemother. 2015 Jun (6) 3585-7

Contemporary genomic approaches in the diagnosis and typing of Staphylococcus aureus.
Williamson DA et al. Pathology 2015 Apr (3) 270-5

CDC information: Methicillin-resistant Staphylococcus aureus (MRSA) is a bacteria that is resistant to many antibiotics. In the community, most MRSA infections are skin infections. In medical facilities, MRSA causes life-threatening bloodstream infections, pneumonia and surgical site infections.

Duke, UConn researchers use protein design algorithms to predict potential resistance mutations in MRSA, by Thomas UG, GenomeWeb, Jan 8 [by paid subscription only]

Superbugs meet their match in rapid genome sequencing. Close to real-time tracking of deadly superbugs such as MRSA promises to close down outbreaks faster and save lives, by Ian Sample, the Guardian, Sep 12, 2014

Hospital-associated MRSA and antibiotic resistance-what have we learned from genomics?
Lindsay JA. Int J Med Microbiol. 2013 Aug;303(6-7):318-23

Promising antibiotic discovered in microbial ‘dark matter’. Potential drug kills pathogens such as MRSA — and was discovered by mining 'unculturable' bacteria, Heidi Ledford, Nature News, Jan 7

Predicting the virulence of MRSA from its genome sequence 
Laabei M, et al. Genome Res, 9 Apr 2014.

MRSA genome predicts toxicity, Bioscience Technology, Apr 9, 2014

Comparative whole genome sequencing of community-associated methicillin-resistant staphylococcus aureus sequence type 8 from primary care clinics in a Texas community. 
Lee GC et al., Pharmacotherapy. 2015 Feb 3. 

Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.
Jones MB, et al. BMC Genomics. 2014 Dec 19;15(1):1145

Metabolic pathway analysis approach: Identification of novel therapeutic target against methicillin resistant Staphylococcus aureus.
Uddin R, et al. Gene. 2015 Feb 10;556(2):213-26.

The genome sequence of a type ST239 methicillin-resistant staphylococcus aureus isolate from a Malaysian hospital.
Lee L, et al. Stand Genomic Sci. 2014 Apr 20;9(3):933-9.

Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus.
Stegger M, et al. MBio. 2014 Aug 26;5(5):e01044-14

Comparative genomics of methicillin-resistant Staphylococcus aureus ST239: distinct geographical variants in Beijing and Hong Kong.
Wang Z, et al. BMC Genomics. 2014 Jun 26;15:529.

Transferable vancomycin resistance in a community-associated MRSA lineage.
Rossi F, et al. N Engl J Med. 2014 Apr 17;370(16):1524-31.