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Genomics|Features|Tuberculosis

Tuberculosis

Tuberculosis: Recent Public Health and Genomic Insights - August 21, 2015

CDC Info

• Tuberculosis: symptoms & risk factors
• "Find TB. Treat TB. Working together to eliminate TB."
• Tuberculosis trends - United States, 2014MMWR, March 20, 2015
• Questions and answers about TB
• Using whole genome sequencing to improve tuberculosis outbreak detection and investigation effectiveness
• Prioritizing tuberculosis clusters by genotype for public health action, Washington, USA,Emerging Infectious Diseases (2013)
• Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.Coscolla Mireia et al. The Journal of infectious diseases 2015 Jan
• Evaluation of a U.S. public health laboratory service for the molecular detection of drug resistant tuberculosis.Yakrus MA, et al. Tuberc Res Treat.2015;2015:701786

Clinical value of whole-genome sequencing of Mycobacterium tuberculosis.

Takiff HE et al. Lancet Infect Dis 2015 Aug 12.

Adverse drug reactions to anti-TB drugs: Pharmacogenomics perspective for identification of host genetic markers.

Sahu RK et al. Curr. Drug Metab. 2015 Aug 12.

Tuberculosis: symptoms & risk factors

Molecular typing of drug-susceptible and -resistant Mycobacterium tuberculosis in Johannesburg, South Africa.

Kamudumuli PS et al. Int. J. Tuberc. Lung Dis. 2015 Jul (7) 834-40

Polymorphism of X-linked CD40 ligand gene associated with pulmonary tuberculosis in the Han Chinese population.

Hu C-Y et al. Genes Immun. 2015 Jun 4.

To be or not to be a pseudogene: A molecular epidemiological approach to the mclx genes and its impact in tuberculosis.

Santos CL et al. PLoS ONE 2015 (6) e0128983

Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.

Gao X et al. PLoS ONE 2015 (6) e0127496

Rapid whole genome sequencing of M. tuberculosis directly from clinical samples.

Brown AC et al. J. Clin. Microbiol. 2015 May 13.

Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing.

Williams OM et al. Emerging Infect. Dis. 2015 Jun (6) 1082-4

The association between Mycobacterium tuberculosis genotype and drug resistance in Peru.

Grandjean L et al. PLoS ONE 2015 (5) e0126271

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis.

Shi GL et al. Genet. Mol. Res. 2015 (2) 4035-40

Systematic review, meta-analysis and economic modelling of molecular diagnostic tests for antibiotic resistance in tuberculosis.

Drobniewski F et al. Health Technol Assess 2015 May (34) 1-188

Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis.

Chen Z et al. BMC Pulm Med 2015 May 8. (1) 57

Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population.

Wu L et al. BMC Med. Genet. 2015 (1) 19

Investigating the role of gene-gene interactions in TB susceptibility.

Daya M et al. PLoS ONE 2014 (4) e0123970

Whole genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis Beijing isolates from an outbreak in Thailand.

Regmi SMi et al. Mol. Genet. Genomics 2015 Apr 24.

Gene expression analysis of two extensively drug-resistant tuberculosis isolates show that two-component response systems enhance drug resistance.

Yu G et al. Tuberculosis (Edinb) 2015 May (3) 303-14

Genetic mutations associated with rifampicin and isoniazid resistance in MDR-TB patients in North-West India.

Kumar P et al. Int. J. Tuberc. Lung Dis. 2015 Apr (4) 434-9

World Tuberculosis Day: March 30, 2015

CDC paper: Evaluation of a U.S. Public Health Laboratory Service for the Molecular Detection of Drug Resistant Tuberculosis

Mitchell AY et al. TB Res & Treatment, March 2015

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.

Curtis J et al. Nat. Genet. 2015 Mar 16.

Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.

Salamon H et al. J. Infect. Dis. 2015 Apr 1. (suppl 2) S50-S57

Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy.

Donoghue HD et al. Tuberculosis (Edinb) 2015 Feb 13.

Evolutionary changes in the genome of Mycobacterium tuberculosis and the human genome from 9000 years BP until modern times.

Spigelman M et al. Tuberculosis (Edinb) 2015 Feb 13.

Clustured regularly interspersed short palindromic repeats (CRISPR) genetic diversity studies as a mean to reconstruct the evolution of the Mycobacterium tuberculosis complex.

Sola C et al. Tuberculosis (Edinb) 2015 Feb 14.

Inherited and acquired immunodeficiencies underlying tuberculosis in childhood.

Boisson-Dupuis S et al. Immunol. Rev. 2015 Mar (1) 103-20

Draft genome sequence of an extensively drug-resistant Mycobacterium tuberculosis manu-ancestor spoligo-international type 523 isolate from Thailand.

Regmi SM et al. Genome Announc 2015 (1)

Genetic diversity of Mycobacterium tuberculosis from Guadalajara, Mexico and identification of a rare multidrug resistant Beijing genotype.

Flores-Treviño S et al. PLoS ONE 2015 (2) e0118095

Tuberculosis: Recent Genomic Insights - February 4, 2015

CDC paper: Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.

Coscolla Mireia et al. The Journal of infectious diseases 2015 Jan

The DNA-binding network of Mycobacterium tuberculosis. Kyle J. Minch et al. Nature Communications, January 20, 2015

Tuberculosis genomes track human history- A pernicious family of TB strains emerged in Asia more than 6,000 years ago, by Ewen Callaway, Nature News and Comments, Jan 19

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Matthias Merker, et al. Nature Genetics, January 19, 2015

Tracking tuberculosis over time

Rood J. The Scientist, Jan 19, 2015.

With genomic analysis, researchers characterize tuberculosis lineage, history, and spread,  GenomeWeb, Jan 19

Tuberculosis: Genomics & Public Health - October 22, 2014

Recent notes from the field: Use of genotyping to disprove a presumed outbreak of mycobacterium tuberculosis — Los Angeles County, 2013–2014

MMWR  October 10, 2014  63(40);907-908

CDC article: Prioritizing tuberculosis clusters by genotype for public health action, Washington, USA, Emerging Infectious Diseases (2013)

CDC information: Using whole genome sequencing to improve tuberculosis outbreak detection and investigation effectiveness

CDC information on tuberculosis

Genomic insights into tuberculosis.

James E. Galagan Nature Reviews Genetics, March 25, 2014

Culture-independent detection and characterisation of Mycobacterium tuberculosis and M. africanum in sputum samples using shotgun metagenomics on a benchtop sequencer

Emma L Doughty et al. Peer J, August 2014

IL-32 is a molecular marker of a host defense network in human tuberculosis

Dennis Montoya et al. Science Translational Medicine, August 20, 2014 



Did you know? More than 700 publications have reported on more than 330 genes in relation to tuberculosis susceptibility & outcomes, including 10 genomewide association studies. To find out more, visit the HuGE Navigator

Human genetics of tuberculosis: a long and winding road.

Laurent Abeet al. Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130428.