Incidental findings || Public Health Genomics Knowledge Base (v1.2) || Incidental findings

Public Health Genomics Knowledge Base (v1.2)



Last Updated: Nov 17, 2016

• Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics
  ACMG, Genetics in Medicine, November 17, 2016
• The fiduciary relationship model for managing clinical genomic "incidental" findings.
  Lázaro-Muñoz Gabriel et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2014 42(4) 576-89
• Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
  P Natarajan et al, Science Translational Medicine, November 10, 2016
• Will Unanticipated Genetic Mutations Lead to Subsequent Disease? 
  Brigham and Women's Hospital press release, November 9, 2016
• Consideration surrounding incidental findings throughout multigene panel testing in cancer genetics.
  Grandval P et al. Clinical genetics 2016 Feb 89(2) 267-8
• PIGSR: A Preference Instrument for Genomics Secondary Results
  CSER Consortium Online Tool
• Accuracy and clinical value of maternal incidental findings during noninvasive prenatal testing for fetal aneuploidies
  A Brison et al, Genetics in Medicine, September 1, 2016
• A Clinical Service to Support the Return of Secondary Genomic Findings in Human Research.
  Darnell Andrew J et al. American journal of human genetics 2016 Mar 98(3) 435-41
• Choices of Incidental Findings of Individuals Undergoing Genome Wide Sequencing, a Single Center's Experience.
  Bishop Callie L et al. Clinical genetics 2016 Jul
• Disclosure of incidental findings in cancer genomic research: investigators' perceptions on obligations and barriers.
  Kleiderman E et al. Clinical genetics 2015 Oct 88(4) 320-6
• Raising Genomic Citizens: Adolescents and the Return of Secondary Genomic Findings.
  Sabatello Maya et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2016 Jun 44(2) 292-308
• Pharmacogenomic incidental findings in 308 families: The NIH Undiagnosed Diseases Program experience.
  Lee Elizabeth M J, et al. Genetics in medicine : official journal of the American College of Medical Genetics 2016 6
• Research participant interest in primary, secondary, and incidental genomic findings.
  Loud Jennifer T et al. Genetics in medicine : official journal of the American College of Medical Genetics 2016 Apr
• Patients' views on incidental findings from clinical exome sequencing.
  Clift Kristin E et al. Applied & translational genomics 2015 Mar 438-43
• A Clinical Service to Support the Return of Secondary Genomic Findings in Human Research
  AJ Darnell et al, AM J Human Genetics, March 3, 2016

• CDC Information (1)
• CDC-Authored Pub (2)

• Human (51)
• Pathogen (0)

• Human (13)
• Pathogen (0)

• Human (53)
• Pathogen (1)

• Guidelines (6)
• Tier Table (0)
• Synthesis (8)

Relevant Resources

• Genetics and Genomics Competencies Center (G2C2)
• NIH Genetic Testing Registry
• NIH MedGen Database
• Online Mendelian Inheritance in Man (OMIM)
• PharmGKB