miércoles, 31 de octubre de 2018

Cystic Fibrosis News Today Weekly Digest


Cystic Fibrosis Weekly Update

Contents:

Santhera Starting Phase 1b/2a Trial Testing Potential CF therapy POL6014

Oct 31, 2018 08:00 am | Ana Pena



POL6014 Phase 1a/2b trialA Phase 1b/2a, dose-escalating clinical trial evaluating the effects of POL6014 in patients with cystic fibrosis (CF) was recently launched, according to Santhera Pharmaceuticals, developer of the investigational therapy.  The Phase 1b/2a (EudraCT 2016-005110-22) will evaluate the safety, tolerability, pharmacokinetics (drug absorption, distribution, and elimination by the body), and pharmacodynamics (the drug’s effects) of orally inhaled […]
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Why Are Our Doctors Not Discussing Herbal Supplements with Us?

Oct 30, 2018 09:00 am | Brad Dell



herbal supplements, CAMThe 2018 North American Cystic Fibrosis Conference (NACFC) in Denver was rad, huh? The Cystic Fibrosis Foundation (CFF) is making great strides in the inclusion of patient voices, which has led to a selection of initiatives based on our feedback. Over the next five years, the foundation will invest $100 million in infection research. Wow. The conference also […]
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VX-445 Triple Combo Improves Lung Function in CF Patients with F508del Mutations, Phase 2 Trial Shows

Oct 30, 2018 08:30 am | Ana Pena



VX-445 Phase 2 trialAdding the investigational therapy VX-445 to tezacaftor (VX-661) and Kalydeco (ivacaftor) led to a roughly 10 percent improvement in the lung function of cystic fibrosis (CF) patients with F508del mutations in the CFTR gene in a proof-of-concept Phase 2 clinical trial.  The treatment was effective in patients with one or two F508del copies (the most common CF-causing mutation), and has […]
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Recent News

#NORDSummit – Major Issues on Table for Rare Disease Patients in US as Midterm Elections Approach
#NACFC2018 — Celtaxsys’ Acebilustat Delays Onset, Reduces Rate of Pulmonary Exacerbations in CF, Phase 2 Study Shows
#NACFC2018 – Preclinical Study Data Demonstrate Lenabasum’s Potential to Prevent Inflammatory Signals in CF
#NACFC2018 — Vertex Presents Latest Clinical Data on CFTR Modulators
PTI-808 and PTI-801 Combo Improves Lung Function in CF Patients, Phase 1 Data Show

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