Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism | BMC Pharmacology and Toxicology | Full Text

Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism | BMC Pharmacology and Toxicology | Full Text

Featured article: Tolerance to NSAIDS and opioids in the brain

Chronic NSAID administration in the anterior cingulate cortex can produce analgesic effects and chronic administration can result in tolerance. The authors also find that the effects of NSAIDs in the brain are mediated by the opioid system.