Translating the microbiome in health and disease
Guest Editor: Ramnik Xavier
Genome Medicine is pleased to present a special issue entitled 'Translating the microbiome in health and disease,' guest edited by Dr. Ramnik Xavier of the Broad Institute of MIT and Harvard. Research efforts exploring the human microbiome using large-scale metagenomics and multi-omics have rapidly expanded, facilitating characterization of microbiome composition, dynamics, variation, and function in health and disease. Such studies are increasing our understanding of the microbiome’s impact on the immune response and other physiological processes, and further enabling a shift from correlation to causation, with emerging insights into how this data can be utilized for diagnostic and therapeutic benefit. These efforts also highlight the need for the standardization of microbiome research protocols in order to accelerate progress through collaborative research. This special issue aims to capture recent insights into all aspects of the human microbiome in health and disease including standards for microbiome analyses in basic and clinical research, microbiome analysis tools and technologies, metagenomics and integrative multi-omics, antibiotics and the microbiome, microbial biochemistry and diet, translational interventions, and host-microbiome interactions. This collection of articles has not been sponsored and articles will undergo the journal’s standard peer-review process. The Guest Editor declares that they have no competing interests. Guest Editors serve an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.
The aging mouse microbiome has obesogenic characteristics
During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on differe...Genome Medicine 2020 12:87Understanding the impact of antibiotic perturbation on the human microbiome
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses that performs essential functions for immune development, pathogen colonization resistance, and food metabolism. Pertur...Genome Medicine 2020 12:82Strain-level epidemiology of microbial communities and the human microbiome
The biological importance and varied metabolic capabilities of specific microbial strains have long been established in the scientific community. Strains have, in the past, been largely defined and characteriz...Genome Medicine 2020 12:71Illuminating the human virome in health and disease
Although the microbiome is established as an important regulator of health and disease, the role of viruses that inhabit asymptomatic humans (collectively, the virome) is less defined. While we are still chara...Genome Medicine 2020 12:66A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis
There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use m...Genome Medicine 2020 12:65High-resolution temporal profiling of the human gut microbiome reveals consistent and cascading alterations in response to dietary glycans
Dietary glycans, widely used as food ingredients and not directly digested by humans, are of intense interest for their beneficial roles in human health through shaping the microbiome. Characterizing the consi...Genome Medicine 2020 12:59Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine
Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating inflammatory bowel diseases and irritable bowel syndrome in an increasing number of randomized controlled trials. Recently published...Genome Medicine 2020 12:58Strain-resolved microbiome sequencing reveals mobile elements that drive bacterial competition on a clinical timescale
Populations of closely related microbial strains can be simultaneously present in bacterial communities such as the human gut microbiome. We recently developed a de novo genome assembly approach that uses read...Genome Medicine 2020 12:50Interactions between the gut microbiome and host gene regulation in cystic fibrosis
Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians. It is caused by mutations in the CFTR gene, leading to poor hydration of mucus and impairment of the respiratory, digestive, a...Genome Medicine 2020 12:12
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