Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE
X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of th...Journal of Biomedical Science 2020 27:31TRIM21–SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis
The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence is a leading clinical bottleneck in NPC. Revealing the mechanism of NPC radioresistance wi...Journal of Biomedical Science 2020 27:30Effects of neural stem cell transplantation in Alzheimer’s disease models
Currently there are no therapies for treating Alzheimer’s disease (AD) that can effectively halt disease progression. Existing drugs such as acetylcholinesterase inhibitors or NMDA receptor antagonists offers ...Journal of Biomedical Science 2020 27:29Schistosomiasis vaccine development: update on human clinical trials
Schistosomiasis causes significant levels of morbidity and mortality in many geographical regions of the world. The disease is caused by infections with parasitic blood flukes known as schistosomes. The contro...Journal of Biomedical Science 2020 27:28Endoplasmic reticulum: a focal point of Zika virus infection
Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpec...Journal of Biomedical Science 2020 27:27Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protei...Journal of Biomedical Science 2020 27:26Differential expression of microRNA, miR-150 and enhancer of zeste homolog 2 (EZH2) in peripheral blood cells as early prognostic markers of severe forms of dengue
Dengue presents a wide clinical spectrum. Most patients recover following a self-limiting non-severe clinical course. A small proportion of patients progress to severe disease, mostly characterized by plasma l...Journal of Biomedical Science 2020 27:25Photoacoustic imaging of cells in a three-dimensional microenvironment
Imaging live cells in a three-dimensional (3D) culture system yields more accurate information and spatial visualization of the interplay of cells and the surrounding matrix components compared to using a two-...Journal of Biomedical Science 2020 27:3Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells
Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosi...Journal of Biomedical Science 2020 27:24Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells
Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CS...Journal of Biomedical Science 2020 27:5Cellular receptors for enterovirus A71
Enterovirus 71 (EV-A71) is one of the major causative agents of hand, foot, and mouth disease. EV-A71 infection is sometimes associated with severe neurological diseases such as acute encephalitis, acute flacc...Journal of Biomedical Science 2020 27:23Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia
Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA,...Journal of Biomedical Science 2020 27:7Translation control of Enterovirus A71 gene expression
Upon EV-A71 infection of a host cell, EV-A71 RNA is translated into a viral polyprotein. Although EV-A71 can use the cellular translation machinery to produce viral proteins, unlike cellular translation, which...Journal of Biomedical Science 2020 27:22Structural basis of polyethylene glycol recognition by antibody
Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for speci...Journal of Biomedical Science 2020 27:12Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq
Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal muc...Journal of Biomedical Science 2020 27:217-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progres...Journal of Biomedical Science 2020 27:20Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model
The FDA approved drug granulocyte-colony stimulating factor (G-CSF) displays anti-apoptotic and immunomodulatory properties with neurogenesis and angiogenic functions. It is known to demonstrate neuroprotectiv...Journal of Biomedical Science 2020 27:19Clinical trials of new drugs for Alzheimer disease
Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Prese...Journal of Biomedical Science 2020 27:18Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation
Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replicati...Journal of Biomedical Science 2020 27:17Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice
Over-stimulation of dopamine signaling is thought to underlie the pathophysiology of a list of mental disorders, such as psychosis, mania and attention-deficit/hyperactivity disorder. These disorders are frequ...Journal of Biomedical Science 2020 27:16Detection and phylogeny of Staphylococcus aureus sequence type 398 in Taiwan
Methicillin-resistant Staphylococcus aureus (MRSA) ST398 is a livestock associated-bacterium that is most prevalent in Europe. Human-adapted MRSA ST398 was recently reported from China, but there is no data avail...Journal of Biomedical Science 2020 27:15The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli
Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections...Journal of Biomedical Science 2020 27:14Bile and urine peptide marker profiles: access keys to molecular pathways and biological processes in cholangiocarcinoma
Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to d...Journal of Biomedical Science 2020 27:13Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis
Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...Journal of Biomedical Science 2020 27:11Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases
Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is consid...Journal of Biomedical Science 2020 27:10Synthetic carbohydrate-based vaccines: challenges and opportunities
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate ...Journal of Biomedical Science 2020 27:9Co-introduction of plasmids harbouring the carbapenemase genes, blaNDM-1 and blaOXA-232, increases fitness and virulence of bacterial host
Bacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host. In ...Journal of Biomedical Science 2020 27:8Therapeutic applications of nucleic acid aptamers in microbial infections
Today, the treatment of bacterial infections is a major challenge, due to growing rate of multidrug-resistant bacteria, complication of treatment and increased healthcare costs. Moreover, new treatments for ba...Journal of Biomedical Science 2020 27:6Role of microRNAs in antiviral responses to dengue infection
Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal and there is currently no effective antiviral agent or vaccine. The only licensed vaccine, Dengvaxia, has low efficacy...Journal of Biomedical Science 2020 27:4Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44
Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated in several solid tumors. We have prev...Journal of Biomedical Science 2020 27:2Development of therapeutic antibodies for the treatment of diseases
It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatica...Journal of Biomedical Science 2020 27:1Correction to: Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
In the original publication of this article [1] the name of the fifth author is uncorrect. The correct name of the fifth author should be Wei-Chiao Chang rather than Wei-Chao Chang. The original publication ha...Journal of Biomedical Science 2019 26:98The original article was published in Journal of Biomedical Science 2019 26:96Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients
Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodie...Journal of Biomedical Science 2019 26:97Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
Dramatic advances in immune therapy have emerged as a promising strategy in cancer therapeutics. In addition to chemotherapy and radiotherapy, inhibitors targeting immune-checkpoint molecules such as cytotoxic...Journal of Biomedical Science 2019 26:96The Correction to this article has been published in Journal of Biomedical Science 2019 26:98Interplays between Enterovirus A71 and the innate immune system
Enterovirus A71 (EV-A71) is a growing threat to public health, particularly in the Asia-Pacific region. EV-A71 infection is most prevalent in infants and children and causes a wide spectrum of clinical complic...Journal of Biomedical Science 2019 26:95The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury
Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain ...Journal of Biomedical Science 2019 26:94Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model
Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and Chi...Journal of Biomedical Science 2019 26:93Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms a...Journal of Biomedical Science 2019 26:92Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, wit...Journal of Biomedical Science 2019 26:91Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors
Toll-like receptors (TLRs) are well known as critical pattern recognition receptors that trigger innate immune responses. In addition, TLRs are expressed in neurons and may act as the gears in the neuronal det...Journal of Biomedical Science 2019 26:90The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates
Effective neurorestorative therapies of neurodegenerative diseases must be developed. There is increasing interest in using human platelet lysates, rich in neurotrophic factors, as novel disease-modifying stra...Journal of Biomedical Science 2019 26:89
Liver microsystems in vitro for drug response
Engineering approaches were adopted for liver microsystems to recapitulate cell arrangements and culture microenvironments in vivo for sensitive, high-throughput and biomimetic drug screening. This review intr...Journal of Biomedical Science 2019 26:88Human iPSC banking: barriers and opportunities
The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based d...Journal of Biomedical Science 2019 26:87
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