Familial hypercholesterolaemia S McErlean, BMJ, July 2023

Familial hypercholesterolemia is a common genetic condition affecting 1 in 310 people, resulting in premature coronary artery disease due to elevated cholesterol levels from birth If a parent has familial hypercholesterolemia, there is a 50% chance their child will inherit the condition. Treatment is based on lowering low density lipoprotein (LDL) cholesterol concentration, with a target of at least 50% reduction from baseline. https://phgkb.cdc.gov/PHGKB/phgHome.action?query=Lipoprotein%20a&action=search&Mysubmit=Search