miércoles, 22 de mayo de 2019

New Issue of NCCIH Update: Message from the Director on Pain Research

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Announcements

Dr. Helene Langevin

NCCIH Director's Message: Perspectives on Pain Research

NCCIH colleagues and I recently participated in the American Pain Society Scientific Meeting in Milwaukee, Wisconsin. The meeting centered on the theme “Combating the Opioid Epidemic Through Innovations in the Treatment of Pain” and offered a valuable forum for sharing scientific findings and insights into the complexities of treating pain. Many NCCIH staff shared their expertise and were available to answer questions about our Center’s role in pain research.


Resources for Researchers

HHS Small Business (SBIR/STTR) Grants Webinar

The Department of Health and Human Services (HHS) has just released the 2019 Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Omnibus Grant Solicitations. An informational webinar will occur on Wednesday, May 29, 2019 at 1 p.m. to 3 p.m. ET. Please register for the HHS SBIR/STTR PHS 2019-2 Grant Omnibus Webinar in advance. After registering, you will receive a confirmation email containing information about joining the webinar.

New Funding Opportunities



Upcoming Events

Pain Lecture: Opioid-induced plasticity and the interaction with pain Opioid-induced plasticity and the interaction with pain 

June 6, 2019, 11 a.m.-12 p.m. ET; Building 35A, Room 640, NIH Main Campus, Bethesda, MD (in-person attendance only)

NCCIH National Advisory Council Meeting

June 7, 2019, 10 a.m.-3:20 p.m. ET; Building 45 (Natcher), Conference Rooms E1/E2, NIH Main Campus, Bethesda, MD. Remote attendance is also being offered for this meeting. 

isaac chiu imls

Bacteria Get on Your Nerves: How Bugs Modulate Pain and Immunity

June 10, 2019, 11 a.m.-12 p.m. ET; Lipsett Amphitheater, NIH Clinical Center, NIH Main Campus, Bethesda, MD. Remote viewing options will be available.

Dr. Isaac Chiu, Assistant Professor of Immunology
Department of Immunology, Harvard Medical School, will give the next lecture in our Integrative Medicine Lecture Series on “Microbes in Our Gut: Emerging Insights on Health and Disease.” Dr. Chiu's lecture will focus on research work to uncover interactions between the nervous system, the immune system, and microbes, in health and disease.


In case you missed it...

Lecture, "Gut Microbes in a Disruptive Age" Video Available

If you missed the May 9 lecture by Dr. Maria Gloria Dominguez-Bello, you can now view an archive of the video.

Plasticity Hums With Protein Synthesis on Both Sides of Synapse | ALZFORUM

Plasticity Hums With Protein Synthesis on Both Sides of Synapse | ALZFORUM

AlzForum

Plasticity Hums With Protein Synthesis on Both Sides of Synapse

17 May 2019


Scientists know that synaptic plasticity requires local protein production from translation of mRNAs in postsynaptic dendrites. However, local synthesis had not been clearly demonstrated on the other, presynaptic side in mature axons. A new study claims that on-the-spot translation on both sides of the synapse fine-tunes the synaptic proteome, and contributes to synaptic plasticity. In the May 17 Science, Erin Schuman, Max Planck Institute for Brain Research, Frankfurt, Germany, and colleagues publish evidence of ongoing, active protein synthesis in both pre- and postsynaptic compartments of neurons from mouse brain. Different types of synaptic plasticity stimulated protein synthesis on one or both sides of the synapse, and did so in distinct ways.

BACE Inhibitors: Postmortem on One, Live Updates on Two | ALZFORUM

BACE Inhibitors: Postmortem on One, Live Updates on Two | ALZFORUM

AlzForum

BACE Inhibitors: Postmortem on One, Live Updates on Two

17 May 2019


At the AD/PD 2019 conference held recently in Lisbon, the amyloid hypothesis was reeling from repeated gut punches in the clinic. Both antibodies and BACE inhibitors are facing relentless criticism from academic scientists and biopharma analysts (e.g., May 2019 news). Lost in the cacophony can be the voices of patients and their families urging researchers to push on, and of site leaders who swear they “saw something” among their participants. A little lost as well, amid all the opinion, can be the data itself. Some anti-amyloid investigational antibodies (see Part 15 of this series) and the active vaccine CAD106 are still in Phase 3 or 2/3, as are elenbecestat and umibecestat. In Lisbon, scientists presented and debated data on both these extant BACE inhibitors as well as an extinct one, lanabecestat.



Paper Alert: VCAM1 Opens the Door to Brain Aging | ALZFORUM

Paper Alert: VCAM1 Opens the Door to Brain Aging | ALZFORUM

AlzForum

News from Alzforum



Mysterious factors in the blood are known to trigger aging in the brain. Though researchers have yet to discover the identities of all these aging agents, they have pegged a protein that lets them do their dirty work. On May 13 in Nature Medicine, researchers led by Tony Wyss-Coray at Stanford University in Palo Alto, California, reported that vascular adhesion molecule 1 (VCAM1) expression on the endothelial cells that line the blood-brain barrier is required for systemic factors to accelerate aging in the mouse brain. Blocking VCAM1 not only countered classic signs of brain aging such as microglial activation and waning neurogenesis, it also bestowed old mice with the memory of murine whippersnappers.

Molecular Neurodegeneration | Home page

Molecular Neurodegeneration | Home page

Molecular Neurodegeneration

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    Authors:Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari and Carlos Cruchaga

Molecular Medicine | Home

Molecular Medicine | Home

Molecular Medicine

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Molecular Cytogenetics | Home page

Molecular Cytogenetics | Home page

Molecular Cytogenetics

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Molecular Cancer | Home page

Molecular Cancer | Home page

Molecular Cancer

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