domingo, 25 de octubre de 2020

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miércoles, 21 de octubre de 2020


Debido a las restricciones impuestas por la corporación Google, que merecen nuestro repudio, este blog no se volverá a editar. Gracias por vuestra comprensión. Octubre de 2020. Gracias por casi trece años de seguimiento.

Mantener el peso depende de su cerebro - Noticias médicas - IntraMed

Mantener el peso depende de su cerebro - Noticias médicas - IntraMed

lunes, 19 de octubre de 2020


definitivamente se prohibe la edición en Google... todo se ha vuelto lamentable e indudablemente parte de la discrecionalidad de la corporación para con los contenidos que intentan evitar se conozcan por este medio... Google demostró su intención en 2019 al hacer desaparecer Google+ y hace lo propio en octubre de 2020 con los Blog´s... seguramente siguiendo un criterio de censura y de destrucción de la propiedad intelectual así como del derecho creativo inherente al ser humano... esta conducta refleja la iniciativa nazi-sionista que envuelve a todo el planeta Tierra y que ha transformado al mundo en un campo de concentración semejante al ghetto de Varsovia... lo que sigue no será bueno... y lo que venga, tampoco... cuando un puñado de idiotas se apropia del futuro de la humanidad, el único resultado posible es la tragedia, cursó con el holocausto y está siendo transitado por estas horas. Triste. el editor. Octubre 19, 2020.-

domingo, 18 de octubre de 2020

Finding Relief for Sciatica - Harvard Health

Finding Relief for Sciatica - Harvard Health


Harvard Medical School

5 tips for coping with sciatica

Sciatica is one of the most common, yet misunderstood, types of pain. As many as 40% of people will get it during their life, and it becomes more frequent as you age. Sciatica tends to get lumped in with regular back pain, but it is different. The pain originates with the sciatic nerves and often goes away by itself within a few hours or days. However, some attacks can come and go for several weeks or even months. Fortunately, there's a lot you can do to prevent sciatica, as well as relieve the pain.
Get your copy of Finding Relief for Sciatica
Finding Relief for Sciatica
In this guide, we will explore sciatica—its causes, risk factors, and treatments. We’ll discuss who is at higher risk for sciatica and how it can be mistaken for other types of nerve pain. We’ll explore at-home care that can help people with sciatica find relief and discuss when it’s advisable to see a doctor. We’ll also discuss medical treatments, such as injections and surgery, that help some people. Finally, we’ll explain ways to prevent sciatica or at least lower your chances of experiencing it.

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Increase exercise

Exercise is a key way to prevent or help relieve sciatica. Consider these types:
  • Aerobic exercise: walking, jogging, swimming, cycling, dancing, and other activities that increase your heart rate without causing more pain if you already have sciatica.
  • Strength training: exercises using free weights or weight machines, or isometric exercises, which involve contracting muscles without obvious movement.
  • Flexibility training: yoga, tai chi, Pilates, and similar activities that increase both flexibility and strength.
Really, any exercise that you can enjoy and do regularly is going to help. So try something new, go back to an old favorite, or both.

Strengthen your core

It might not seem obvious that a stronger core could improve your spinal health. But your core is not just your abdominal muscles, even though they are key contributors to the stability of your spine. Muscles in the back, sides, pelvis, and buttocks also are part of your core. Strengthening all of these muscles helps to support your spine.
Many types of exercise, including yoga and Pilates, can strengthen the core muscles. For example, planks and bridges are movements that target the core. 

Avoid sitting for long periods

Prolonged periods of sitting put pressure on the discs and ligaments in the low back. If you have a job that requires a lot of sitting, take frequent breaks, or try a standing desk. Less sitting is better.

Manage your weight

Being overweight or obese can increase your risk for sciatica. And people who have sciatica and are overweight tend to heal more slowly. Why? The increased weight puts pressure on your spine and can lead to herniated discs. Even minor weight loss will reduce inflammation and pressure on the spine.

Practice good posture

Mom was right—slouching isn't good for you. But you don't have to walk around the room with a book on your head to practice good posture. Follow these tips:
  • Pay attention to your body's position when you're standing or sitting.
  • To prevent slouching, pull your shoulders down and back. Imagine your shoulder blades touching.
  • If you work at a computer, take frequent breaks. Position your monitor so you can see it without bending your head down or tilting it back.
To learn more about ways to ease your sciatica pain, purchase Finding Relief for Sciatica from Harvard Health Publishing.

Image: © gilaxia | Getty Images
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Finding Relief for Sciatica

Featured content:

What is sciatica?
Causes of sciatica
Risk factors
Home remedies and self-care
When to see a doctor
Treatments prescribed by a doctor
Prevention and coping

Click here to read more »

sábado, 17 de octubre de 2020

Genes and Environment | Home page

Genes and Environment | Home page

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Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 | Genes and Environment | Full Text

Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 | Genes and Environment | Full Text

[Pick Up]Mutagenic, Genotoxic and Immunomodulatory Effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19

GE4114Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by healthcare workers and common people as a prophylactic drug against the Corona Virus Disease -19 (COVID-19) in several parts of the world. There are no clinical studies that have established any clinical efficacy of these drugs as a prophylactic against COVID-19. In this review, the authors elucidated the mechanism of immunomodulation by both HCQ and CQ and highlighted the mutagenic and genotoxic effects from the available literature. This article is written with the sole objective that the reader will be able to recognize the adverse effects of these drugs when consumed by healthy individuals as a prophylactic. Current evidence cumulatively demonstrates that CQ is a mutagenic and genotoxic drug and both HCQ and CQ are not effective against the COVID-19 infection either as post-exposure prophylaxis or as a curative drug. The authors concluded that healthy individuals should refrain from the use of these drugs as prophylactics until further investigation.

Genome Medicine | Home page

Genome Medicine | Home page


BMC collection: hepatitis C

BMC collection: hepatitis C

BMC Collection: Hepatitis C

New Content ItemThe 2020 Nobel Prize for Physiology or Medicine was awarded on the 5th of October to Harvey J. Alter, Michael Houghton and Charles M. Rice for their discovery of Hepatitis C virus. In celebration of what they started and showcasing areas of research that have since emerged, we here present a collection of articles from the BMC BiologyBMC MedicineGenome Medicine and the BMC Series Journals on biology, diagnosis and treatment and wider public health and medical outcomes of the Hepatitis C virus and its infection.

Viral biology and biology of infection:

Viral hijacking of cellular metabolism
Shivani K. Thaker, James Ch’ng & Heather R. Christofk
Review BMC Biology 17: 59 (2019) 
Full text        PDF

Development and biological activity of long-acting recombinant human interferon-α2b
Qian Zhang, Chao Wang, Fenlian Ma, Lihong Yao, Hanchun Gao, Luyan Zhu & Lishu Zheng
Research article BMC Biotechnology 20: 16 (2020)  
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Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway
Xiao-Hua Jiang, Yu-Tao Xie, Ya-Ping Cai, Jing Ren & Tao Ma
Research article BMC Microbiology 17: 124 (2017)  
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Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations
Ken-ichi Mori, Akihiro Matsumoto, Noboru Maki, Yuki Ichikawa, Eiji Tanaka & Shintaro Yagi
Research article BMC Microbiology 16: 224 (2016)  
Full text        PDF

HCVIVdb: The hepatitis-C IRES variation database
Evan W. Floden, Anas Khawaja, Václav Vopálenský & Martin Pospíšek
Database BMC Microbiology 16: 187 (2016)  
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Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3
Sanja Glišić, David P. Cavanaugh, Krishnan K. Chittur, Milan Sencanski, Vladimir Perovic & Tijana Bojić
Research article BMC Bioinformatics 17: 139 (2016)
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Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
Katherine R Smith, Vijayaprakash Suppiah, Kate O'Connor, Thomas Berg, Martin Weltman, Maria Lorena Abate, Ulrich Spengler, Margaret Bassendine, Gail Matthews, William L Irving, Elizabeth Powell, Stephen Riordan, Golo Ahlenstiel, Graeme J Stewart, Melanie Bahlo, Jacob George, David R Booth & the International Hepatitis C Genetics Consortium (IHCGC)
Research article Genome Medicine 3: 57 (2011) 
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The mode and tempo of hepatitis C virus evolution within and among hosts
Rebecca R Gray, Joe Parker, Philippe Lemey, Marco Salemi, Aris Katzourakis & Oliver G Pybus
Research article BMC Evolutionary Biology 11: 131 (2011) 
Full text        PDF

The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry
Vera Rocha-Perugini, Muriel Lavie, David Delgrange, Jonathan Canton, André Pillez, Julie Potel, Cécile Lecoeur, Eric Rubinstein, Jean Dubuisson, Czeslaw Wychowski & Laurence Cocquerel
Research article BMC Microbiology 9: 111 (2009)  
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Diagnosis and treatment:

Beyond clinical outcomes: the social and healthcare system implications of hepatitis C treatment
Marta Torrens, Tokunbo Soyemi, Darcy Bowman & Eberhard Schatz
Research article BMC Infectious Diseases 20: 702 (2020) Sep 20
Full text        PDF
Hepatitis C virus infection characteristics and treatment outcomes in Canadian immigrants
Curtis L. Cooper, Daniel Read, Marie-Louise Vachon, Brian Conway, Alexander Wong, Alnoor Ramji, Sergio Borgia, Ed Tam, Lisa Barrett, Dan Smyth, Jordan J. Feld, Sam Lee & on behalf of the CANUHC Cohort
Research article BMC Public Health 20: 1345 (2020)  
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Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis
Abraham Nigussie Mekuria, Michael N. Routledge, Yun Yun Gong & Mekonnen Sisay
Research article BMC Pharmacology and Toxicology 21: 39 (2020)  
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Treatment outcomes of patients with chronic hepatitis C receiving sofosbuvir-based combination therapy within national hepatitis C elimination program in the country of Georgia
Tengiz Tsertsvadze, Amiran Gamkrelidze, Muazzam Nasrullah, Lali Sharvadze, Juliette Morgan, Shaun Shadaker, Lia Gvinjilia, Maia Butsashvili, David Metreveli, Vakhtang Kerashvili, Marina Ezugbaia, Nikoloz Chkhartishvili, Akaki Abutidze, Valeri Kvaratskhelia & Francisco Averhoff
Research article BMC Infectious Diseases 20: 30 (2020) 
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A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments
Andrew Radley, Emma Robinson, Esther J. Aspinall, Kathryn Angus, Lex Tan & John F. Dillon
Research article BMC Health Services Research 19: 765 (2019)  
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The case for a universal hepatitis C vaccine to achieve hepatitis C elimination
Nick Scott, David P. Wilson, Alexander J. Thompson, Eleanor Barnes, Manal El-Sayed, Adele Schwartz Benzaken, Heidi E. Drummer & Margaret E. Hellard
Research article BMC Medicine 17: 175 (2019)  
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Usefulness of automated assays for detecting hepatitis B and C markers in dried blood spot samples
Livia Melo Villar, Helena Medina Cruz, Raissa Martins Deodato, Juliana Custódio Miguel, Elisangela Ferreira da Silva, Geane Lopes Flores & Lia Laura Lewis-Ximenez
Research note BMC Research Notes 12: 523 (2019)  
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Detection of virus-specific polymeric immunoglobulin A in acute hepatitis A, C, E virus serum samples using novel chimeric secretory component
Khayriyyah Mohd Hanafiah, Mary L. Garcia, Nadine C. Barnes & David A. Anderson
Research note BMC Research Notes 11: 688 (2018)  
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Cost-effectiveness of diagnostic and therapeutic interventions for chronic hepatitis C: a systematic review of model-based analyses
Rodolfo Castro, Louise Crathorne, Hugo Perazzo, Julio Silva, Chris Cooper, Jo Varley-Campbell, Daniel Savignon Marinho, Marcela Haasova, Valdilea G. Veloso, Rob Anderson & Chris Hyde
Research article BMC Medical Research Methodology 18: 53 (2018)  
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Evaluating screening approaches for hepatocellular carcinoma in a cohort of HCV related cirrhosis patients from the Veteran’s Affairs Health Care System
Nabihah Tayob, Peter Richardson, Donna L. White, Xiaoying Yu, Jessica A. Davila, Fasiha Kanwal, Ziding Feng & Hashem B. El-Serag
Research article BMC Medical Research Methodology 18: 1 (2018) 
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Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents
Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang & Dan-Qing Song
Research article Chemistry Central Journal (BMC Chemistry) 11: 94 (2017)  
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Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD
Nourah Zoman Al-Zoman, Hadir Mohamed Maher & Amal Al-Subaie
Research article Chemistry Central Journal (BMC Chemistry) 11: 1 (2017)  
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Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis
Alexander L. Greninger, Samia N. Naccache, Scot Federman, Guixia Yu, Placide Mbala, Vanessa Bres, Doug Stryke, Jerome Bouquet, Sneha Somasekar, Jeffrey M. Linnen, Roger Dodd, Prime Mulembakani, Bradley S. Schneider, Jean-Jacques Muyembe-Tamfum, Susan L. Stramer & Charles Y. Chiu
Method Genome Medicine 7: 99 (2015)  
Full text        PDF
Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma
Masao Honda, Taro Yamashita, Tatsuya Yamashita, Kuniaki Arai, Yoshio Sakai, Akito Sakai, Mikiko Nakamura, Eishiro Mizukoshi & Shuichi Kaneko
Research article BMC Cancer 13: 191 (2013)  
Full text        PDF

Pharmacogenomics of hepatitis C infections: personalizing therapy
David R Booth, Golo Ahlenstiel & Jacob George
Review Genome Medicine 4: 99 (2012)  
Full text        PDF

Medical and Public health outcomes:

Prevalence of hepatitis C in the adult population of Bulgaria: a pilot study
Ida Sperle, Stine Nielsen, Martyna Gassowski, Zlatina Naneva, Tanya Perchemlieva, Andrew Amato-Gauci, Matthias an der Heiden, Viviane Bremer, Elitsa Golkocheva-Markova, Kristiyan Hristov, Elena Kaneva, Yanita Simeonova, Tencho Tenev, Tonka Varleva, Erika Duffell & Ruth Zimmermann
Research note BMC Research Notes 13: 326 (2020) 
Full text        PDF

Patient and healthcare provider experiences of hepatitis C treatment with direct-acting antivirals in Rwanda: a qualitative exploration of barriers and facilitators
Janvier Serumondo, Michael J. Penkunas, Julienne Niyikora, Alida Ngwije, Athanase Kiromera, Emmanuel Musabeyezu, Justine Umutesi, Sabine Umuraza, Gentille Musengimana & Sabin Nsanzimana
Research article BMC Public Health 20: 946 (2020) 
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Clients’ perceptions of barriers and facilitators to implementing hepatitis C virus care in homeless shelters
Carmen L. Masson, J. Konadu Fokuo, August Anderson, Jesse Powell, Barry Zevin, Dylan Bush & Mandana Khalili
Research article BMC Infectious Diseases 20: 386 (2020)
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Eliminating viral hepatitis C in Belgium: the micro-elimination approach
Dana Busschots, Samira Toghanian, Rob Bielen, Stina Salomonsson, Özgür M. Koc, Greet Hendrickx, Michel Jadoul, Frederik Nevens, Etienne Sokal, Christian Brixko, Kathelijne Peerlinck, Ludwig Apers, Geert Robaeys & Jeffrey V. Lazarus
Research article BMC Infectious Diseases 20: 181 (2020)
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Hepatitis C virus genotype affects survival in patients with hepatocellular carcinoma
Hye Kyong Park, Sang Soo Lee, Chang Bin Im, Changjo Im, Ra Ri Cha, Wan Soo Kim, Hyun Chin Cho, Jae Min Lee, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung & Ok-Jae Lee
Research article BMC Cancer 19: 822 (2019) 
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Linkage to hepatitis C care after incarceration in jail: a prospective, single arm clinical trial
Matthew J. Akiyama, Devin Columbus, Ross MacDonald, Alison O. Jordan, Jessie Schwartz, Alain H. Litwin, Benjamin Eckhardt & Ellie Carmody
Research article BMC Infectious Diseases 19: 703 (2019)
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Improving engagement with healthcare in hepatitis C: a randomised controlled trial of a peer support intervention
Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, André Charlett & Ibrahim Abubakar
Research article BMC Medicine 17: 71 (2019) 
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Short-term budget affordability of hepatitis C treatments for state Medicaid programs
Jacquelyn W. Chou, Alison R. Silverstein & Dana P. Goldman
Research article BMC Health Services Research 19: 140 (2019)
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The HCV Synthesis Project: Scope, methodology, and preliminary results
Rebecca K Stern, Holly Hagan, Corina Lelutiu-Weinberger, Don Des Jarlais, Roberta Scheinmann, Shiela Strauss, Enrique R Pouget & Peter Flom
Research article BMC Medical Research Methodology 8: 62 (2008)
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