Glycoscience in Medicine

Edited by Dr Chiaho Shih and Dr Fu-Tong Liu

A thematic series in Journal of Biomedical Science.

Dissecting the conformation of glycans and their interactions with proteins
The use of in silico strategies to develop the structural basis for a rational optimization of glycan-protein interactions remains a great challenge. This problem derives, in part, from the lack of technologie...
Authors:Sheng-Hung Wang, Tsai-Jung Wu, Chien-Wei Lee and John Yu
Citation:Journal of Biomedical Science 2020 27:93
Content type:Review

Published on: 9 September 2020
- ViewFull Text
- ViewPDF
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis
N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein.....
Authors:Ying-Nai Wang, Heng-Huan Lee, Jennifer L. Hsu, Dihua Yu and Mien-Chie Hung
Citation:Journal of Biomedical Science 2020 27:77
Content type:Review

Published on: 3 July 2020
- ViewFull Text
- ViewPDF
O-GlcNAcylation and its role in the immune system
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of nuclear or cytoplasmic proteins by O-GlcN...
Authors:Yi-Hsuan Chang, Chia-Lin Weng and Kuo-I Lin
Citation:Journal of Biomedical Science 2020 27:57
Content type:Review

Published on: 29 April 2020
- ViewFull Text
- ViewPDF
Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases
Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is consid...
Authors:Takashi Angata
Citation:Journal of Biomedical Science 2020 27:10
Content type:Review

Published on: 3 January 2020
- ViewFull Text
- ViewPDF