lunes, 31 de agosto de 2020

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The COVID-19 Forecast Hub
The COVID-19 Forecast Hub, August 2020
This site maintains the authoritative, up-to-date record for forecasts of COVID-19 deaths and hospitalizations in the US, created by dozens of leading infectious disease modeling teams from around the globe, in coordination with CDC.
Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing
WE Allen et al, Nature Human Behavior, August 26, 2020
We developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behavior and demographics. Here, we report results from over 500,000 users in the United States. We show that self-reported surveys can be used to build predictive models to identify likely COVID-19-positive individuals.
Male patients had higher plasma levels of innate immune cytokines such as IL-8 and IL-18 along with more robust induction of non-classical monocytes. Female patients mounted significantly more robust T cell activation than male patients during SARS-CoV-2 infection. Importantly, we found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.
Instead of single, fixed physical distance rules, we propose graded recommendations that better reflect the multiple factors that combine to determine risk. This would provide greater protection in the highest risk settings but also greater freedom in lower risk settings, potentially enabling a return towards normality in some aspects of social and economic life.

Disparities [NEW TOPIC PAGE]

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Coronavirus [NEW TOPIC PAGE]

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Coronavirus

Bridging digital health divides
A Agrawal, Science, August 28, 2020
The COVID-19 pandemic has accelerated digital health implementation in India and elsewhere, such as this telemedicine hub in New Delhi, expanding the reach of health care.
Emerging Pandemic Diseases: How We Got to COVID-19.
Morens David M et al. Cell 2020 Aug
Disease emergence reflects dynamic balances and imbalances, within complex globally distributed ecosystems comprising humans, animals, pathogens, and the environment. Understanding these variables is a necessary step in controlling future devastating disease emergences.
Global and Local Mutations in Bangladeshi SARS-CoV-2 Genomes
MM Hasan et al, BIORXIV, August 26, 2020
https://www.medrxiv.org/content/10.1101/2020.08.24.20181008v1
F Volpato et al, MEDRXIV, August 26, 2020

Coronavirus [NEW TOPIC PAGE]

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Coronavirus

For every 1,000 people infected with the coronavirus who are under the age of 50, almost none will die. For people in their fifties and early sixties, about five will die — more men than women. The risk then climbs steeply as the years accrue. For every 1,000 people in their mid-seventies or older who are infected, around 116 will die.
Development and evaluation of a rapid CRISPR-based diagnostic for COVID-19.
Hou Tieying et al. PLoS pathogens 2020 Aug (8) e1008705
We developed a rapid and sensitive diagnostic for SARS-CoV-2 infection, and compared it to sequencing-based metagenomic and RT-PCR-based assays in a clinical cohort. The test demonstrated a sensitivity level of near single copy and was highly specific without cross reacting to related pathogens. It takes only 40 mins and provides a valuable alternative to the conventional RT–PCR assay to circumvent the bottlenecks in assay turnaround time.
People with moderate to severe asthma may be at higher risk of getting very sick from COVID-19. COVID-19 can affect your nose, throat, lungs (respiratory tract); cause an asthma attack; and possibly lead to pneumonia and acute respiratory disease.
A recent study suggests that pregnant women with COVID-19 are more likely to be hospitalized and are at increased risk for intensive care unit (ICU) admission and receipt of mechanical ventilation than nonpregnant women. Risk of death is similar for both groups. But much remains unknown.
We developed P-BEST - a method for Pooling-Based Efficient SARS-CoV-2 Testing which identifies all positive subjects within a large set of samples using a single round of testing. Each sample is assigned into multiple pools using a combinatorial pooling strategy based on compressed sensing designed for maximizing carrier detection.
Inspired by a mother’s question, the new method will be introduced across Israel this fall, just in time for flu season, and could be coming soon to the U.S.

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Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Wyllie Anne L et al. The New England journal of medicine 2020 Aug
Given the growing need for testing, our findings provide support for the potential of saliva specimens in the diagnosis of SARS-CoV-2 infection. Collection of saliva samples by patients negates the need for interaction with health care workers, a source of testing bottlenecks. This also alleviates demands for supplies of swabs and personal protective equipment.

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Proteomics [NEW TOPIC PAGE]

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