lunes, 31 de agosto de 2020

Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB


The COVID-19 Forecast Hub
The COVID-19 Forecast Hub, August 2020
This site maintains the authoritative, up-to-date record for forecasts of COVID-19 deaths and hospitalizations in the US, created by dozens of leading infectious disease modeling teams from around the globe, in coordination with CDC.
Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing
WE Allen et al, Nature Human Behavior, August 26, 2020
We developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behavior and demographics. Here, we report results from over 500,000 users in the United States. We show that self-reported surveys can be used to build predictive models to identify likely COVID-19-positive individuals.
Male patients had higher plasma levels of innate immune cytokines such as IL-8 and IL-18 along with more robust induction of non-classical monocytes. Female patients mounted significantly more robust T cell activation than male patients during SARS-CoV-2 infection. Importantly, we found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.
Instead of single, fixed physical distance rules, we propose graded recommendations that better reflect the multiple factors that combine to determine risk. This would provide greater protection in the highest risk settings but also greater freedom in lower risk settings, potentially enabling a return towards normality in some aspects of social and economic life.

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