A gene-by-sex interaction contributes to liver disease susceptibility in women Nature Medicine, October 2, 2023

https://phgkb.cdc.gov/PHGKB/phgHome.action?query=Gene-environment%20interaction&action=search&Mysubmit=Search From the abstract: "Clinical and population-based cohorts revealed an interaction between the inherited PNPLA3 p.I148M variant and female sex in determining liver disease. Transcriptomic and functional studies showed that the mechanism encompasses ERa-dependent upregulation of PNPLA3 in hepatocytes, highlighting a target for precision medicine therapeutics in cisgender women. "