IPSE Infiltrates Nuclei Through Clathrin-Mediated Endocytosis

IPSE infiltrates nuclei through clathrin-mediated endocytosis IPSE, a protein excreted by the parasite Schistosoma mansoni, infiltrates the nuclei of urothelial cells through clathrin-mediated endocytosis (a process by which cells absorb metabolites, hormones and proteins). Once inside the nucleus, IPSE modulates gene expression, increasing cell proliferation and angiogenesis. Parasitic eggs trigger upregulation of inflammation genes To better understand the interplay between the parasite Schistosoma haematobium and its human host, a team led by Children’s National Hospital injected 6,000 S. haematobium eggs into the bladder wall of seven-week-old experimental models. After four days, they isolated RNA for analysis, comparing differences in gene expression. Making healthcare innovation for children a priority Recently, Kurt Newman, M.D., president and CEO of Children’s National Hospital, authored an opinion piece for the popular political website, The Hill. In the article, he called upon stakeholders from across the landscape to address the significant innovation gap in children’s healthcare versus adults. Tailoring treatments to young patients Children’s National Hospital president and CEO, Kurt Newman, M.D., recently spoke with Modern Healthcare about the soon-to-open Children’s National Research & Innovation Campus and how it will help address the lagging development of devices, medications and technologies specifically designed to help children.

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