Parkinson's Disease - a series of reviews
This series, guest-edited by Mark Cookson and Ted Dawson, collates reviews surrounding the topic of Parkinson's Disease to provide a comprehensive oversight of recent advances and viewpoints across the field.Initiation and propagation of α-synuclein aggregation in the nervous system
The two main pathological hallmarks of Parkinson’s disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy patho...Molecular Neurodegeneration 2020 15:19LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson’s disease, a considerable amount of work has gone into uncovering its basic cellula...Molecular Neurodegeneration 2019 14:49Glucocerebrosidase and its relevance to Parkinson disease
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related synucleinopathies. A great d...Molecular Neurodegeneration 2019 14:36Impaired dopamine metabolism in Parkinson’s disease pathogenesis
A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A multiple-hit hypothesis has...Molecular Neurodegeneration 2019 14:35Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atro...Molecular Neurodegeneration 2019 14:29Glial phagocytic clearance in Parkinson’s disease
An emerging picture suggests that glial cells’ loss of beneficial roles or gain of toxic functions can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes have been shown to...Molecular Neurodegeneration 2019 14:16Dementia with Lewy bodies: an update and outlook
Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is charac...Molecular Neurodegeneration 2019 14:5Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system (CNS), which affects mostly older adults. In recent years, the incidence of PD has been dramaticall...Molecular Neurodegeneration 2019 14:3
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