domingo, 21 de junio de 2020

The COVID-19 pandemic and health inequalities. Bambra Clare et al. Journal of epidemiology and community health 2020 Jun

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Coronavirus

The COVID-19 pandemic and health inequalities.
Bambra Clare et al. Journal of epidemiology and community health 2020 Jun
COVID-19: molecular diagnostics overview.
Touma Marlin et al. Journal of molecular medicine (Berlin, Germany) 2020 Jun
Researchers have found that the virus’s genetic diversity in most countries is similar to what it is globally, suggesting that it was introduced repeatedly by many infected people in each country. The analysis found 198 mutations that have occurred more than once, indicating that the virus is undergoing selective pressure as it adapts to its human host.
The N3C will create an analytics platform to systematically collect clinical, laboratory and diagnostic data from health care provider organizations nationwide. It will then harmonize the aggregated information into a standard format and make it available rapidly for researchers and health care providers.
We investigate the development of resistance against four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as when combined into cocktails. These antibodies remain effective against spike variants that have arisen in the human population.
Genotyping SARS-CoV-2 through an interactive web application
H Maan et al, Lancet Digital Health, June 12, 2020
Although platforms to survey epidemiological data are prevalent, tools that summarise publicly available viral genome data are scarce and those that are available do not offer users the ability to analyse in-house sequencing data. To address this gap, we have developed an accessible application, the COVID-19 Genotyping Tool (CGT).
We estimated that 1·7 billion (UI 1·0–2·4) people, comprising 22% (UI 15–28) of the global population, have at least one underlying condition that puts them at increased risk of severe COVID-19 if infected (ranging from <5% of those younger than 20 years to >66% of those aged 70 years or older).

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