Genomic diversity and hotspot mutations in 30,983 SARS-CoV-2 genomes: moving toward a universal vaccine for the "confined virus"? T Alouane et al, BIORXIV, June 21, 2020

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Genomic diversity and hotspot mutations in 30,983 SARS-CoV-2 genomes: moving toward a universal vaccine for the "confined virus"?
T Alouane et al, BIORXIV, June 21, 2020

we analyzed the sequences of 30,983 complete genomes from 80 countries from December 24, 2019 to May 13, 2020, and compared them to the reference genome. Our analysis revealed the presence of 3,206 variant sites compared to the reference Wuhan-Hu-1 genome, with a distribution that is largely uniform over all continents.

A Unique Clade of SARS-CoV-2 Viruses is Associated with Lower Viral Loads in Patient Upper Airways
RL Redondo et al, MEDRXIV, June 22, 2020

This study shows that multiple variants of SARS-CoV-2 are circulating in the Chicago area that differ in their relative viral loads in patient upper airways. These data suggest that differences in virus genotype impact viral load and may in turn influence viral transmission and spread.

A Combined Deep CNN-LSTM Network for the Detection of Novel Coronavirus (COVID-19) Using X-ray Images
MZ Islam et al, MEDRXIV, June 20, 2020

Cardiometabolic traits, sepsis and severe covid-19 with respiratory failure: a Mendelian randomization investigation
PJ Mark et al, MEDRXIV, June 20, 2020

This mendelian randomization study used the UK biobank to investigate the role of several traits with COVID-19 severity. The findings support a causal effect of elevated BMI and smoking on risk of sepsis and severe covid-19. Clinical and public health interventions targeting obesity and smoking are likely to reduce sepsis and covid-19 related morbidity,

Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study.
TC Williams et al, MEDRXIV, June 20, 2020

Sewage surveillance for the presence of SARS-CoV-2 genome as a useful wastewater based epidemiology (WBE) tracking tool in India
S Arora et al MEDRXIV, June 20, 2020

Clinical Sensitivity and Interpretation of PCR and Serological COVID-19 Diagnostics for Patients Presenting to the Hospital
TE Miller et al, MEDRXIV, June 20, 2020

Spread dynamics of SARS-CoV-2 epidemic in China: a phylogenetic analysis
H Guohu et al, BIORXIV, June 20, 2020

Structural variability, expression profile and pharmacogenetics properties of TMPRSS2 gene as a potential target for COVID-19 therapy
A Zarubin et al, BIORXIV, June 20, 2020

Host cell factors important for BHV-1 cell entry revealed by genome-wide CRISPR knockout screen
WS Tan et al, BIORXIV, June 19, 2020

High-density amplicon sequencing identifies community spread and ongoing evolution of SARS-CoV-2 in the Southern United States
RP McNamara et al, BIORXIV June 19, 2020

A Survey of COVID-19 Contact Tracing Apps
N Ahmed et al, ARXIV June 18, 2020