lunes, 2 de octubre de 2023
¿Qué fármacos podrían ser de utilidad para el tratamiento, basado en la cronoterapia, de los trastornos cardiovasculares?
https://www.siicsalud.com/tit/profevalprin.php
Se estima que alrededor del 20% de los adultos normotensos tiene un patrón de presión arterial non-dipper y, por lo tanto, están expuestos a un riesgo relativamente alto de enfermedad cardiovascular.
domingo, 1 de octubre de 2023
Where Medical Statistics Meets Artificial Intelligence. David J Hunter et al. N Engl J Med 2023 9 (13) 1211-1219 Artificial intelligence
From the paper: " The very features that make AI a valuable tool for data analysis are the same ones that make it vulnerable from a statistical perspective. This paradox is particularly pertinent for medical science. Techniques that are adequate for targeted advertising to voters and consumers or that enhance weather prediction may not meet the rigorous demands of risk prediction or diagnosis in medicine.7,8 In this review article, we discuss the statistical challenges in applying AI to biomedical data analysis and the delicate balance that researchers face in wishing to learn as much as possible from data while ensuring that data-driven conclusions are accurate, robust, and reproducible. "
https://phgkb.cdc.gov/PHGKB/phgHome.action?query=Artificial%20intelligence&action=search&Mysubmit=Search
Emerging cancer risks in BRCA2 pathogenic germline variant carriers. Patrick R Benusiglio et al. Eur J Hum Genet 2023 9
https://phgkb.cdc.gov/PHGKB/phgHome.action?action=archive&date=09/28/2023
From the paper: "Carriers of pathogenic germline variants (PGV) in BRCA2 could soon be offered gastric cancer screening using gastroscopy. In the longer term, some might even take part in lung cancer screening programs. Indeed, while the risks of breast, ovarian, pancreatic and prostate cancer have been documented for years, recent data show an increased risk of gastric cancer, and suggest an association with lung cancer. This article focuses specifically on BRCA2, while sidelining its sister gene BRCA1, as evidence for a broad cancer spectrum is much stronger for the former."
https://phgkb.cdc.gov/PHGKB/phgHome.action?query=Brca&action=search&Mysubmit=Search
Risk factor for Parkinson's discovered in genes from people of African descent J Hamilton, NPR, September 24, 2023
https://phgkb.cdc.gov/PHGKB/phgHome.action?action=all%20hot%20topics
From the website: "A global effort to make genetic studies more diverse has led to a discovery about Parkinson's disease, a common brain disorder that can impair a person's ability to move and speak. A team that included scientists from Lagos, London and the U.S. found a previously unknown gene variant that can nearly quadruple the risk of Parkinson's for people of African ancestry. "
https://phgkb.cdc.gov/PHGKB/phgHome.action?action=home
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