Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA | BMC Cancer | Full Text

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA | BMC Cancer | Full Text

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Featured article: Early cancer detection - Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of cfDNA

Blood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, detection of cancer using tumor-derived cfDNA has proven challenging. Here Dr. Putcha et al. show that a machine learning approach using cfDNA achieved high sensitivity and specificity in a large, early-stage, colorectal cancer cohort.