Coronavirus Disease PHGKB|Home|PHGKB

Coronavirus Disease PHGKB|Home|PHGKB

 Spotlight on COVID-19

Prognostic factors for severity and mortality in patients infected with COVID-19: A living systematic review protocol
A Izcovich et al, MEDRXIV, April 11, 2020

The objective of our systematic review is to identify prognostic factors of patients infected with COVID-19. Design This is the protocol of a living systematic review. We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L-OVE (Living OVerview of Evidence).

Estimates of the Undetected Rate among the SARS-CoV-2 Infected using Testing Data from Iceland
JH Stock et al, MEDRXIV, April 11, 2020

We use results from Iceland's two testing programs to estimate the share of infections that are undetected under standard (NUHI) testing guidelines. Our primary estimates for the fraction of infections that are undetected range from 88.7% to 93.6%.

Blueprint for a Pop-up SARS-CoV-2 Testing Lab
Innovative Genomics Institute, MedRX, April 12, 2020

Here we describe the strategy we used to establish a CLIA-licensed clinical laboratory to perform a validated Laboratory-Developed Test (LDT) for SARS-CoV-2 in Berkeley, California and the surrounding Bay Area community. Our procedures for implementing the technical, regulatory, and data management workstreams.

Introductions and early spread of SARS-CoV-2 in the New York City area
ASG Reiche et al, MedRXIV, April 11, 2020

To identify the early events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced COVID19 in patients seeking care at one of the hospitals of Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV2 genomes indicates multiple, independent but isolated introductions mainly from Europe and other parts of the United States.