domingo, 26 de abril de 2020

Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

Coronavirus

The Public Health Impact of COVID-19: Why Host Genomics?
MJ Khoury el al, CDC Blog, April 21, 2020 Brand
Ideally, scientific studies of COVID-19 risk factors for transmission and severity should include both viral and human genomes and the interaction of these two genomes, along with other traditional environmental, social and economic factors, and emerging types of big data. This is part of a precision public health response.
We developed a new online database that contains the most updated published scientific literature, online news and reports, CDC and National Institutes of Health resources. The tool captures emerging discoveries and applications of genomics, molecular, and other precision health tools in the investigation and control of coronavirus diseases.
Using advanced genomic technology, scientists made two disconcerting discoveries. The first was that the virus brought in by someone who arrived from Wuhan carrying a nearly identical strain — had managed to settle into the population undetected. Then they began to realize how far it had spread.
Based on deterministic compartment models we propose an empirical top-down modeling approach to provide epidemic forecasts and risk calculations for (local) outbreaks. We use neural networks to develop leading indicators based on available data for different regions.
We analysed data from two large multimorbidity studies to determine appropriate adjustment factors for clustering and multimorbidity. Results We estimate that 1.7 (1.0 - 2.4) billion individuals (22% [15-28%] of the global population) are at increased risk of severe COVID-19 disease
Interleukin-6 blockade for severe COVID-19
M Roumier et al, MEDRXIV, APril 22, 2020

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