Caption: DNA (blue) loops around nucleosomes (gray) and is bound by transcription factors (red), proteins that switch genes on and off and act in a tissue-specific manner. When cells die, enzymes (scissors) chop up areas between the nucleosomes and transcription factors, releasing DNA fragments in unique patterns. By gathering the released DNA fragments in blood, researchers can tell which types of cells produced them.
Credit: Shendure Lab/University of Washington
Last Posted: Jan 25, 2018
- Simple blood test detects eight different kinds of cancer- ‘Liquid biopsy’ technique looks for genetic mutations and proteins linked with tumours.
H Ledford, Nature News, Jan 18, 2018 - Unique Genetic Profiles from Cerebrospinal Fluid Cell-free DNA in Leptomeningeal Metastases of EGFR-mutant Non-Small Cell Lung Cancer: A New Medium of Liquid Biopsy.
Li Y S, et al. Annals of oncology : official journal of the European Society for Medical Oncology 2018 1 - A Hard Look At Liquid Biopsies
D Lowe, Science Translational Medicine Blog, Jan 22, 2018 - Detection and localization of surgically resectable cancers with a multi-analyte blood test
JD Cohen et al, Science, Jan 18, 2018 - Scientists Edge Closer To A Blood Test To Detect Cancers
R Harris, NPR, Jan 18, 2018 - Simple blood test detects eight different kinds of cancer- ‘Liquid biopsy’ technique looks for genetic mutations and proteins linked with tumours.
H Ledford, Nature News, Jan 18, 2018
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