Jelle Van Schooten & Mathieu Claireaux
Jelle van Schooten is a PhD candidate in the laboratory of Dr. Marit van Gils at the Academic Medical Center in Amsterdam. He works on the characterization of antibody responses in HIV-1 glycoprotein immunized and SHIV infected non-human primates to inform future HIV-1 vaccine design.
Mathieu is a postdoctoral researcher in the laboratory of Dr. Marit van Gils at the Academic Medical Center in Amsterdam. He is working on the T follicular helper cell response in HIV infection and following vaccination. He holds a PhD degree in Virology from Institut Pasteur, where he studied the CD4+ T cell response in controlled HIV infection.
Mathieu is a postdoctoral researcher in the laboratory of Dr. Marit van Gils at the Academic Medical Center in Amsterdam. He is working on the T follicular helper cell response in HIV infection and following vaccination. He holds a PhD degree in Virology from Institut Pasteur, where he studied the CD4+ T cell response in controlled HIV infection.
Natural Killer cells as key regulators of broadly neutralizing antibody responses during HIV-1 infection
December 1st was World AIDS Day. To mark the occasion we invited a series of blogs by authors and editors from Retrovirology and AIDS Research and Therapy to talk about the latest research into the treatment and prevention of HIV/AIDS. Continuing the discussion, Jelle van Schooten and Mathieu Claireaux tell us about the work being done to better understand the role of the innate immune system in developing acquired immunity, paving the way for HIV-1 vaccines.
AIDS virus particle, artwork
© Russell Kightley / Science Photo Library
Approximately 20-30% of HIV-1 infected individuals develop broadly neutralizing antibodies (bnAbs) after years of infection, but knowing how to induce these bnAbs in a vaccination setting remains elusive. Studying the development of bnAbs in natural HIV-1 infection might unravel how bnAbs could be elicited by vaccines.
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