Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 +/− - driven murine colonic adenomas | BMC Cancer | Full Text

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 +/− - driven murine colonic adenomas | BMC Cancer | Full Text

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1+/−-driven murine colonic adenomas

The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with hi...

Authors:Jessica L. Preston and Nicholas Stiffler

Citation:BMC Cancer 2020 20:126

Content type:Research article

Published on: 14 February 2020

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