The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas | Acta Neuropathologica Communications | Full Text

The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas | Acta Neuropathologica Communications | Full Text

The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces,...

Authors:Matthew McCord, Alicia Steffens, Rodrigo Javier, Kwok-Ling Kam, Kathleen McCortney and Craig Horbinski

Citation:Acta Neuropathologica Communications 2020 8:15

Content type:Research

Published on: 12 February 2020

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