Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice | Clinical Epigenetics | Full Text

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice | Clinical Epigenetics | Full Text

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

Hexanucleotide repeat expansions of the G4C2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues fr...

Authors:Nur Jury, Sebastian Abarzua, Ivan Diaz, Miguel V. Guerra, Estibaliz Ampuero, Paula Cubillos, Pablo Martinez, Andrea Herrera-Soto, Cristian Arredondo, Fabiola Rojas, Marcia Manterola, Adriana Rojas, Martín Montecino, Lorena Varela-Nallar and Brigitte van Zundert

Citation:Clinical Epigenetics 2020 12:32

Content type:Research

Published on: 18 February 2020

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