The National Lung Matrix Trial of personalized therapy in lung cancer.
Middleton Gary et al. Nature 2020 Jul
Middleton Gary et al. Nature 2020 Jul
Despite pre-clinical data supporting the drug–biomarker combinations, current evidence shows that a limited number of combinations demonstrate clinically relevant benefits, which remain concentrated in patients with lung cancers that are associated with minimal exposure to tobacco smoke.
An umbrella approach to test lung cancer therapies
A Drilon et al, Nature News, July 15, 2020
A Drilon et al, Nature News, July 15, 2020
A clinical trial has tested the use of gene-sequencing results for lung cancer to match patients to targeted therapies. Some paired treatments were a good fit, but others did not succeed, for reasons that will require further exploration.
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