Coronavirus Disease PHGKB|Home|PHGKB

Coronavirus Disease PHGKB|Home|PHGKB

 Spotlight

Covid-19 and Health Care's Digital Revolution.
Keesara Sirina et al. The New England journal of medicine 2020 Apr

As an analogue system, health care is ill equipped to cope with this swiftly emerging epidemic. The U.S. health care industry is structured on the historically necessary model of in-person interactions between patients and their clinicians.

Population based estimates of comorbidities affecting risk for complications from COVID-19 in the US
ML Adams et al, MEDRXIV, April 2, 2020

We used 2017 Behavioral Risk Factor Surveillance System (BRFSS) data (N=444,649) to estimate the proportion of US adults who report comorbidities that suggest heightened risk of complications from COVID-19. Overall 45.4% (95% CI 45.1-45.7) of adults reported any of the 6 comorbidities, increasing from 19.8% for ages 18-29 years to 80.7% for ages 80+ years

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy
R Asselta et al, MEDRXIV, April 2, 2020

Our analysis suggests a role for TMPRSS2 variants and expression levels in modulating COVID-19 severity, a hypothesis that fosters a rapid experimental validation on large cohorts of patients with different clinical manifestations.

I Have a BRCA1 Gene Mutation: The Extra Stress of COVID-19 Takes a Toll
N McCoy, blog April 2, 2020

For those who already live with uncertainty, these extraordinary times offer new challenges. For those living with hereditary risk for cancer, the increased isolation and increased time to process can also feel overwhelming.