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 Spotlight on COVID-19

NIH to launch public-private partnership to speed COVID-19 vaccine and treatment options
NIH, April 17, 2020

Therapeutic Interventions and Vaccines (ACTIV) partnership will develop a collaborative framework for prioritizing vaccine and drug candidates, streamlining clinical trials, coordinating regulatory processes and/or leveraging assets among all partners to rapidly respond to the COVID-19 and future pandemics.

International Electronic Health Record-Derived COVID-19 Clinical Course Profile: The 4CE Consortium
GA Brat et al, MEDRXIV, April 18, 2020

A consortium of international hospital systems utilizing Informatics for Integrating Biology and the Bedside (i2b2) and Observational Medical Outcomes Partnership (OMOP) platforms was convened to address the COVID-19 epidemic. Over a course of two weeks, the group initially focused on admission comorbidities and temporal changes in key laboratory test values.

CoroNet: A Deep Network Architecture for Semi-Supervised Task-Based Identification of COVID-19 from Chest X-ray Images
S Khobahi et al, MEDRXIV, April 17, 2020

We establish the use of a rapid, non-invasive and cost-effective X-ray-based method as a key diagnosis and screening tool for COVID-19 at early and intermediate stages of the disease. We develop a novel and sophisticated deep learning-based signal and image processing technique as well as classification methodology for analyzing X-ray images.

Association of inflammatory markers with the severity of COVID-19
F Zeng et al, MEDRXIV, April 1, 2020

16 studies were included comprising 3962 patients with COVID-19. Non-severe COVID-19 patients had lower levels for CRP, PCT, IL-6, ESR, SAA and serum ferritin. Moreover, survivors had lower level for IL-6 than non-survivors. This meta-analysis highlights the association of inflammatory markers with the severity of COVID-19.