R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers
Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...BMC Cancer 2020 20:531A novel nomogram to predict the reliability of estimated glomerular filtration rate formulae in oncology patients
Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agre...BMC Cancer 2020 20:530The patient-level effect of the cost of Cancer care – financial burden in German Cancer patients
Financial toxicity of cancer has so far been discussed primarily in the US health care system and is associated with higher morbidity and mortality. In European health care systems, the socio-economic impact o...BMC Cancer 2020 20:529Meeting psychosocial needs to improve health: a prospective cohort study
Cancer impacts on patients and their families across a range of different domains. For that reason, optimal cancer care has moved away from a disease-centric focus to a more holistic approach in order to proac...BMC Cancer 2020 20:528Activity of PD1 inhibitor therapy in advanced sarcoma: a single-center retrospective analysis
Sarcomas constitute a heterogeneous group of tumors with different clinical behaviors and variable responses to systemic therapies. Recent immunotherapy studies with PD1 inhibitors (PD1i) show promising result...BMC Cancer 2020 20:527Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase
Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparagina...BMC Cancer 2020 20:526Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis
Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRI...BMC Cancer 2020 20:525The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments
Xenograft mouse tumor models are used to study mechanisms of tumor growth and metastasis formation and to investigate the efficacy of different therapeutic interventions. After injection the engrafted cells fo...BMC Cancer 2020 20:524INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies
Pediatric patients with relapsed or refractory disease represent a population with a desperate medical need. The aim of the INFORM (INdividualized Therapy FOr Relapsed Malignancies in Childhood) program is to ...BMC Cancer 2020 20:523miR-874 inhibits gastric cancer cell proliferation by targeting SPAG9
microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported in various human cancers, its role in GC remains obscure.BMC Cancer 2020 20:522Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma
Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...BMC Cancer 2020 20:521Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma
According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Du...BMC Cancer 2020 20:520Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck
Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targete...BMC Cancer 2020 20:519Optimal cumulative dose of cisplatin for concurrent chemoradiotherapy among patients with non-metastatic nasopharyngeal carcinoma: a multicenter analysis in Thailand
Chemoradiotherapy (CRT) with high cumulative doses (CDs) of cisplatin has been considered the standard of care for non-metastatic nasopharyngeal carcinoma (NPC). However, given most patients’ inability to tole...BMC Cancer 2020 20:518Clinical significance of prognostic inflammation-based and/or nutritional markers in patients with stage III gastric cancer
Although many studies have identified several inflammation-based and/or nutritional markers with prognostic value for patients with various types of cancer, the optimal markers and cut-off values for these mar...BMC Cancer 2020 20:517The molecular pathogenesis of Trichilemmal carcinoma
Trichilemmal carcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC to gain insight into its molecular pathogenesis.BMC Cancer 2020 20:516A retrospective study of patient-tailored FOLFIRINOX as a first-line chemotherapy for patients with advanced biliary tract cancer
FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined wi...BMC Cancer 2020 20:515Preoperative clinical characteristics scoring system for differentiating uterine leiomyosarcoma from fibroid
Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study...BMC Cancer 2020 20:514Factors predictive of invasive ductal carcinoma in cases preoperatively diagnosed as ductal carcinoma in situ
Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biop...BMC Cancer 2020 20:513Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models
Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the proges...BMC Cancer 2020 20:512Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. ...BMC Cancer 2020 20:511Effect of aspirin on PET parameters in primary non-small cell lung cancer and its relationship with prognosis
18 F-FDG is a glucose analogue whose metabolic index SUV can effectively reflect the metabolic level of tumor microenvironment. Aspirin can affect the uptake of 18F-FDG by cancer cells, reducing the SUVmax val...BMC Cancer 2020 20:510Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas
Meningiomas are the most common primary intracranial tumors in adults. They are initially detected with neuroimaging techniques, but definite histological diagnosis requires tumor surgery to collect tumor tiss...BMC Cancer 2020 20:509Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study
Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed ...BMC Cancer 2020 20:508Similar response rates and survival with PARP inhibitors for patients with solid tumors harboring somatic versus Germline BRCA mutations: a Meta-analysis and systematic review
PARP inhibitors (PARPi) have recently been approved for various malignancies based on the results of several clinical trials. However, these trials have mostly recruited patients with germline BRCA mutations, ...BMC Cancer 2020 20:507Biomarker roles identification of miR-106 family for predicting the risk and poor survival of colorectal cancer
Recent studies have extensively investigated the roles of miR-106 in colorectal cancer (CRC). However, the associations and molecular mechanism underlying the roles of miR-106 in CRC remain unclear. We aimed t...BMC Cancer 2020 20:506Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis
Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico...BMC Cancer 2020 20:491SCDb: an integrated database of stomach cancer
Stomach cancer (SC) is a type of cancer, which is derived from the stomach mucous membrane. As there are non-specific symptoms or no noticeable symptoms observed at the early stage, newly diagnosed SC cases us...BMC Cancer 2020 20:490A convenient clinical nomogram for predicting the cancer-specific survival of individual patients with small-intestine adenocarcinoma
The objective of this study was to develop a practical nomogram for predicting the cancer-specific survival (CSS) of patients with small-intestine adenocarcinoma.BMC Cancer 2020 20:505A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function
The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring...BMC Cancer 2020 20:504Ipilimumab or FOLFOX with Nivolumab and Trastuzumab in previously untreated HER2-positive locally advanced or metastatic EsophagoGastric Adenocarcinoma - the randomized phase 2 INTEGA trial (AIO STO 0217)
Esophagogastric adenocarcinoma (EGA) currently represents a main cause of cancer related death. Despite an intensified treatment for locally advanced or metastatic EGA with a doublet chemotherapy consisting of...BMC Cancer 2020 20:503Machine-learning based MRI radiomics models for early detection of radiation-induced brain injury in nasopharyngeal carcinoma
Early radiation-induced temporal lobe injury (RTLI) diagnosis in nasopharyngeal carcinoma (NPC) is clinically challenging, and prediction models of RTLI are lacking. Hence, we aimed to develop radiomic models ...BMC Cancer 2020 20:502Craniospinal irradiation(CSI) in patients with leptomeningeal metastases: risk-benefit-profile and development of a prognostic score for decision making in the palliative setting
The aim of our study was to assess the feasibility and oncologic outcomes in patients treated with spinal (SI) or craniospinal irradiation (CSI) in patients with leptomeningeal metastases (LM) and to suggest a...BMC Cancer 2020 20:501Optimize the dose of oxaliplatin for locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy followed by radical surgery and adjuvant chemotherapy
Addition of oxaliplatin to capecitabine remains controversial for locally advanced rectal cancer (LARC). And cumulative oxaliplatin dose (COD) varied among clinical trials showing different therapeutic effects...BMC Cancer 2020 20:498MassARRAY analysis of twelve cancer related SNPs in esophageal squamous cell carcinoma in J&K, India
MassARRAY (Agena Bioscience™) combines competitive PCR with MALDI-TOF mass spectrometry (MS) analysis that gives highly accurate, sensitive, and high-throughput methods for the quantitative analysis of variati...BMC Cancer 2020 20:497Augmenting cancer registry data with health survey data with no cases in common: the relationship between pre-diagnosis health behaviour and post-diagnosis survival in oesophageal cancer
For epidemiological research, cancer registry datasets often need to be augmented with additional data. Data linkage is not feasible when there are no cases in common between data sets. We present a novel appr...BMC Cancer 2020 20:496Improving communication between the general practitioner and the oncologist: a key role in coordinating care for patients suffering from cancer
Patients suffering from cancers are increasingly numerous in general practice consultations. The General Practitioner (GP) should be at the heart of the management of patients. Several studies have examined th...BMC Cancer 2020 20:495Diagnostic and prognostic nomograms for bone metastasis in hepatocellular carcinoma
Bone metastasis (BM) is one of the common sites of hepatocellular carcinoma (HCC), and the prognosis of BM patients is worse than patients without it. Our study aimed to identify predictors and prognostic fact...BMC Cancer 2020 20:494Association between Epstein-Barr virus infection and gastric cancer: a systematic review and meta-analysis
Numerous studies conducted over the past 30 years have pointed to the presence of Epstein–Barr virus (EBV) in gastric cancer samples. This study was aimed to provide a meta-analytic review of the prevalence of...BMC Cancer 2020 20:493A phase II randomized trial of RAdium-223 dichloride and SABR Versus SABR for oligomEtastatic prostate caNcerS (RAVENS)
Metastasis directed therapy (MDT) for patients with oligometastatic disease is associated with improvements in progression free survival (PFS) and overall survival (OS) compared to systemic therapy alone. Addi...BMC Cancer 2020 20:492
martes, 9 de junio de 2020
BMC Cancer | Articles
BMC Cancer | Articles
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