Liquid biopsy [NEW TOPIC PAGE]

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Caption: DNA (blue) loops around nucleosomes (gray) and is bound by transcription factors (red), proteins that switch genes on and off and act in a tissue-specific manner. When cells die, enzymes (scissors) chop up areas between the nucleosomes and transcription factors, releasing DNA fragments in unique patterns. By gathering the released DNA fragments in blood, researchers can tell which types of cells produced them.
Credit: Shendure Lab/University of Washington

From PubMed Clinical Queries

PubMed Clinical Queries is an utility offered by PubMed to search scientific literature in specific clinical research areas

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• Search PubMed Clinical Queries for "Liquid biopsy" 

Results: 5 of 842

• A high-throughput liquid biopsy for rapid rare cell separation from large-volume samples.
  Liu Y, Li T, Xu M, Zhang W, Xiong Y, Nie L, Wang Q, Li H, Wang W.Lab Chip. 2018 Dec 5; . Epub 2018 Dec 5.
• Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.
  Cremolini C, Rossini D, Dell'Aquila E, Lonardi S, Conca E, Del Re M, Busico A, Pietrantonio F, Danesi R, Aprile G, et al.JAMA Oncol. 2018 Nov 21; . Epub 2018 Nov 21.
• Assessment of Reported Trial Characteristics, Rate of Publication, and Inclusion of Mandatory Biopsies of Research Biopsies in Clinical Trials in Oncology.
  Parseghian CM, Tam AL, Yao J, Ensor J Jr, Ellis LM, Raghav K, Overman MJ.JAMA Oncol. 2018 Nov 1; . Epub 2018 Nov 1.
• Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer.
  Usuba W, Urabe F, Yamamoto Y, Matsuzaki J, Sasaki H, Ichikawa M, Takizawa S, Aoki Y, Niida S, Kato K, et al.Cancer Sci. 2018 Nov 1; . Epub 2018 Nov 1.
• Surgical Management of Advanced Kidney Cancer: The Role of Cytoreductive Nephrectomy and Lymphadenectomy.
  Patel HD, Karam JA, Allaf ME.J Clin Oncol. 2018 Oct 29; :JCO2018790246. Epub 2018 Oct 29.

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This column displays citations filtered to a specific clinical study category and scope. These search filters were developed by Haynes RB et al. See more filter information.

Systematic Reviews

Results: 5 of 74

• Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review.
  Vymetalkova V, Cervena K, Bartu L, Vodicka P.Int J Mol Sci. 2018 Oct 26; 19(11). Epub 2018 Oct 26.
• Liquid biopsy prediction of axillary lymph node metastasis, cancer recurrence, and patient survival in breast cancer: A meta-analysis.
  Lee JH, Jeong H, Choi JW, Oh HE, Kim YS.Medicine (Baltimore). 2018 Oct; 97(42):e12862.
• Can urinary biomarkers replace cystoscopy?
  Maas M, Bedke J, Stenzl A, Todenhöfer T.World J Urol. 2018 Oct 3; . Epub 2018 Oct 3.
• Liquid Biopsy as Surrogate to Tissue in Lung Cancer for Molecular Profiling: A Meta-Analysis.
  Mlika M, Dziri C, Zorgati MM, Ben Khelil M, Mezni F.Curr Respir Med Rev. 2018 Mar; 14(1):48-60.
• Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: A Systematic Evidence Review for the U.S. Preventive Services Task Force
  Melnikow J, Henderson JT, Burda BU, Senger CA, Durbin S, Soulsby MA.2018 Aug.

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This column displays citations for systematic reviews, meta-analyses, reviews of clinical trials, evidence-based medicine, consensus development conferences, and guidelines. See filter information or additional related sources.

Medical Genetics

Topic:AllDiagnosisDifferential DiagnosisClinical DescriptionManagementGenetic CounselingMolecular GeneticsGenetic Testing

Results: 5 of 1126

• A Novel Multiplex droplet digital PCR Assay to Identify and Quantify KRAS Mutations in Clinical Specimens.
  Alcaide M, Cheung M, Bushell K, Arthur SE, Wong HL, Karasinska J, Renouf D, Schaeffer DF, McNamara S, Tertre MCD, et al.J Mol Diagn. 2018 Nov 22; . Epub 2018 Nov 22.
• Targeted sequencing of Plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations.
  Palsgrove DN, Taheri D, Springer SU, Cowan M, Guner G, Mendoza Rodriguez MA, Del Carmen Rodriguez Pena M, Wang Y, Kinde I, Ricardo BFP, et al.Hum Pathol. 2018 Nov 14; . Epub 2018 Nov 14.
• Cell-Free DNA From Metastatic Pancreatic Neuroendocrine Tumor Patients Contains Tumor-Specific Mutations and Copy Number Variations.
  Boons G, Vandamme T, Peeters M, Beyens M, Driessen A, Janssens K, Zwaenepoel K, Roeyen G, Van Camp G, Op de Beeck K.Front Oncol. 2018; 8:467. Epub 2018 Nov 1.
• Current and future perspectives of liquid biopsies in genomics-driven oncology.
  Heitzer E, Haque IS, Roberts CES, Speicher MR.Nat Rev Genet. 2018 Nov 8; . Epub 2018 Nov 8.
• Analysis of cervical human papillomavirus infection in 2300 women in Urumqi, China.
  Yao L, Yuan M, Yuan J, Zhou P, Mei L, Cheng J.Medicine (Baltimore). 2018 Nov; 97(45):e13206.

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This column displays citations pertaining to topics in medical genetics. See more filter information.