Caption: DNA (blue) loops around nucleosomes (gray) and is bound by transcription factors (red), proteins that switch genes on and off and act in a tissue-specific manner. When cells die, enzymes (scissors) chop up areas between the nucleosomes and transcription factors, releasing DNA fragments in unique patterns. By gathering the released DNA fragments in blood, researchers can tell which types of cells produced them.
Credit: Shendure Lab/University of Washington
Credit: Shendure Lab/University of Washington
From National Institutes of Health Web Sites
- A New Tool in the Toolbox: New Method Traces Free-Floating DNA Back to Its Source
Francis Collins, NIH Director, Blog Post, February 16, 2016 - Circulating Cell Free DNA: Applications in the Clinical and Toxicology Setting
NIEHS, Workshop, September 24-25, 2018 - Detecting early signs of cancer in the blood
NIH Research matters, August 29, 2017 - Liquid Biopsy: Using DNA in Blood to Detect, Track, and Treat Cancer
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