miércoles, 27 de febrero de 2019

BMC Cancer | Cell and molecular biology

BMC Cancer | Cell and molecular biology

Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.
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  1. Content Type:Research Article

    Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following...
    Authors:Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews and Christopher Bradley
    Citation:BMC Cancer 2019 19:179
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  2. Content Type:Research Article

    Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits osteoclastogenesis. Emerging evidence suggests that ZA has anti-tumor and anti-metastatic properties for breast cancer cells. In a mouse mod...
    Authors:Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen and Tsun-Mei Lin
    Citation:BMC Cancer 2019 19:176
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  3. Content Type:Research Article

    Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) ...
    Authors:Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu and Xipeng Wang
    Citation:BMC Cancer 2019 19:171
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  4. Content Type:Research Article

    Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utiliz...
    Authors:Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha and Patrick E. Chappell
    Citation:BMC Cancer 2019 19:158
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  5. Content Type:Research Article

    Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical impor...
    Authors:Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton and Sebastian G. B. Furness
    Citation:BMC Cancer 2019 19:157
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  6. Content Type:Research Article

    Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells)....
    Authors:Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu
    Citation:BMC Cancer 2019 19:153
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  7. Content Type:Research Article

    A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...
    Authors:Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim
    Citation:BMC Cancer 2019 19:148
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  8. Content Type:Research Article

    Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...
    Authors:Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc
    Citation:BMC Cancer 2019 19:137
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  9. Content Type:Research Article

    Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a...
    Authors:Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir
    Citation:BMC Cancer 2019 19:135
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  10. Content Type:Research Article

    Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The...
    Authors:Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid and Fabian D. Mairinger
    Citation:BMC Cancer 2019 19:108
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  11. Content Type:Research Article

    In this report we examine candidate pathways perturbed by Compound Kushen Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to alter the gene expression patterns of multiple p...
    Authors:Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang and David L. Adelson
    Citation:BMC Cancer 2019 19:103
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  12. Content Type:Research Article

    Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and pro...
    Authors:Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma and Jian Lu
    Citation:BMC Cancer 2019 19:94
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  13. Content Type:Research Article

    Podoplanin (PDPN) is a mucin-type transmembrane glycoprotein specific to the lymphatic system. PDPN expression has been found in various human tumors and is considered to be a marker of cancer. We had previous...
    Authors:Justyna Sikorska, Damian Gaweł, Hanna Domek, Magdalena Rudzińska and Barbara Czarnocka
    Citation:BMC Cancer 2019 19:85
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  14. Content Type:Research Article

    BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expressi...
    Authors:Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson and Kiven Erique Lukong
    Citation:BMC Cancer 2019 19:78
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  15. Content Type:Research Article

    Invasive micropapillary carcinoma (IMPC) of the breast is characterized by its unique morphology and frequent nodal metastasis. However, the mechanism for development of this unique subtype has not been clearl...
    Authors:Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi and Takuya Moriya
    Citation:BMC Cancer 2019 19:76
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  16. Content Type:Research Article

    Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (C...
    Authors:Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda and Olivia Fromigué
    Citation:BMC Cancer 2019 19:62
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  17. Content Type:Case Report

    Philadelphia (Ph) chromosome results from the reciprocal translocation t(9;22)(q34.1;q11.2) and is diagnostic for chronic myeloid leukemia (CML). However, this translocation is also found in acute lymphoid leu...
    Authors:Monica Piedimonte, Tiziana Ottone, Valentina Alfonso, Antonella Ferrari, Esmeralda Conte, Mariadomenica Divona, Maria Paola Bianchi, Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Alessia Campagna, Laura Cicconi, Giulia Galassi, Sabrina Pelliccia, Annapaola Leporace, Francesco Lo Coco…
    Citation:BMC Cancer 2019 19:50
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  18. Content Type:Research Article

    The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a p...
    Authors:Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber and Simone Muenst
    Citation:BMC Cancer 2019 19:41
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  19. Content Type:Research Article

    We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on...
    Authors:Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee and Dae Seog Heo
    Citation:BMC Cancer 2019 19:19
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  20. Content Type:Research Article

    Gastric cancer (GC) is a common malignant disease worldwide. Aberrant miRNAs expression contributes to malignant cells behaviour, and in preclinical research, miRNA targeting has shown potential for improving ...
    Authors:Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu and Jianlin Ren
    Citation:BMC Cancer 2019 19:14
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  21. Content Type:Research Article

    Reliable methods are needed to identify patients with early-stage cancer or high-grade precancerous lesions in the pancreas. Analysis of pancreatic juice to detect somatic mutations could represent one such ap...
    Authors:Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland and Anders Molven
    Citation:BMC Cancer 2019 19:11
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  22. Content Type:Research Article

    Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels. As a soybean-isoflavone product, genistein has estroge...
    Authors:Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park and Eui-Ju Hong
    Citation:BMC Cancer 2019 19:6
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  23. Content Type:Research Article

    MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Ther...
    Authors:Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang and Xingsheng Yang
    Citation:BMC Cancer 2018 18:1294
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  24. Content Type:Research Article

    Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear...
    Authors:Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang and Huanzhou Xue
    Citation:BMC Cancer 2018 18:1286
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  25. Content Type:Research Article

    Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such...
    Authors:Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright and Mark D. Temple
    Citation:BMC Cancer 2018 18:1284
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  26. Content Type:Research Article

    Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic o...
    Authors:Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi and Rakesh K. Singh
    Citation:BMC Cancer 2018 18:1283
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  27. Content Type:Research Article

    Breast cancer is the most common malignancy in women affecting one out of eight females throughout their lives. Autotaxin (ATX) is upregulated in breast cancer which results in increased lysophosphatidic acid ...
    Authors:Rafael Schmid, Katharina Wolf, Jan W. Robering, Selina Strauß, Pamela L. Strissel, Reiner Strick, Matthias Rübner, Peter A. Fasching, Raymund E. Horch, Andreas E. Kremer, Anja M. Boos and Annika Weigand
    Citation:BMC Cancer 2018 18:1273
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  28. Content Type:Research Article

    We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the p...
    Authors:Yi Xu, Xiaoyu Yang, Di Gao, Liu Yang, Keith Miskimins and Steven Y. Qian
    Citation:BMC Cancer 2018 18:1268
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  29. Content Type:Research Article

    Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration. The aim of this study was to determine the effects of leptin on the antioxidant response in th...
    Authors:Sinda Mahbouli, Jérémie Talvas, Audrey der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson and Adrien Rossary
    Citation:BMC Cancer 2018 18:1264
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  30. Content Type:Research Article

    Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions. GR...
    Authors:Christopher N. Cultrara, Stephen D. Kozuch, Poornema Ramasundaram, Claudia J. Heller, Sunil Shah, Adah E. Beck, David Sabatino and Jenny Zilberberg
    Citation:BMC Cancer 2018 18:1263
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  31. Content Type:Research Article

    FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating...
    Authors:Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola and Ratna Chakrabarti
    Citation:BMC Cancer 2018 18:1257
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  32. Content Type:Research Article

    The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is character...
    Authors:Taoufik Nedjadi, Anthony Evans, Adnan Sheikh, Lawrence Barerra, Suliman Al-Ghamdi, Lucy Oldfield, W. Greenhalf, John P. Neoptolemos and Eithne Costello
    Citation:BMC Cancer 2018 18:1255
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  33. Content Type:Research Article

    Non-muscle invasive bladder cancers (NMIBC: pTa, pT1) are characterised by a high risk of recurrence and/or progression. Identification of prognostic markers is needed to improve both diagnosis and management ...
    Authors:Christel Mathis, Isabelle Lascombe, Franck Monnien, Hugues Bittard, François Kleinclauss, Isabelle Bedgedjian, Sylvie Fauconnet and Séverine Valmary-Degano
    Citation:BMC Cancer 2018 18:1239
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  34. Content Type:Research Article

    The current treatment of malignant melanoma is limited by the lack of effective therapeutic approaches, and alternative treatments are needed. Proliferative diseases such as melanoma and other cancers may be t...
    Authors:Marina Teras, Edda Viisileht, Merlis Pahtma-Hall, Airi Rump, Viiu Paalme, Pille Pata, Illar Pata, Christelle Langevin and Sirje Rüütel Boudinot
    Citation:BMC Cancer 2018 18:1237
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  35. Content Type:Research Article

    Curcumin, a primary active ingredient extracted from the Curcuma longa, has been recently identified as a potential anti-tumor agent in multiple kinds of cancers. However, the effect of curcumin on retinoblastoma...
    Authors:Yaping Li, Weixuan Sun, Ning Han, Ying Zou and Dexin Yin
    Citation:BMC Cancer 2018 18:1230
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  36. Content Type:Research Article

    Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression sig...
    Authors:Annabelle Monnier, Rachel Boniface, Régis Bouvet, Amandine Etcheverry, Marc Aubry, Tony Avril, Véronique Quillien, Eric Chevet and Jean Mosser
    Citation:BMC Cancer 2018 18:1213
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  37. Content Type:Research Article

    Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are ...
    Authors:Juri Ogishima, Ayumi Taguchi, Akira Kawata, Kei Kawana, Mitsuyo Yoshida, Yuki Yoshimatsu, Masakazu Sato, Hiroe Nakamura, Yoshiko Kawata, Akira Nishijima, Asaha Fujimoto, Kensuke Tomio, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Tohru Kiyono…
    Citation:BMC Cancer 2018 18:1201
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  38. Content Type:Research Article

    Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes depende...
    Authors:Diana Andrejeva, Jan-Michael Kugler, Hung Thanh Nguyen, Anders Malmendal, Mette Lind Holm, Birgitte Groenkaer Toft, Anand C. Loya and Stephen M. Cohen
    Citation:BMC Cancer 2018 18:1180
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  39. Content Type:Research Article

    The dysregulation of miR-663a is frequently observed in many human cancers. However, the functional role and precise mechanism of miR-663a have been controversial in hepatocellular carcinoma (HCC) and need to ...
    Authors:Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Ning Sun, Guoqing Zhang and Jialin Zhang
    Citation:BMC Cancer 2018 18:1179
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  40. Content Type:Research Article

    It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterize...
    Authors:Gloria Pelizzo, Veronica Veschi, Melissa Mantelli, Stefania Croce, Vincenzo Di Benedetto, Paolo D’Angelo, Alice Maltese, Laura Catenacci, Tiziana Apuzzo, Emanuela Scavo, Antonia Moretta, Matilde Todaro, Giorgio Stassi, Maria Antonietta Avanzini and Valeria Calcaterra
    Citation:BMC Cancer 2018 18:1176
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  41. Content Type:Research Article

    Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-cateni...
    Authors:S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan and D. Velmurugan
    Citation:BMC Cancer 2018 18:1168
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  42. Content Type:Research Article

    Glycosylation plays a critical role in the aggressiveness of pancreatic cancer (PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in PC aggressiveness. However, the importanc...
    Authors:Srikanth Barkeer, Seema Chugh, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Satyanarayana Rachagani, Surinder K. Batra and Moorthy P. Ponnusamy
    Citation:BMC Cancer 2018 18:1157
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  43. Content Type:Research Article

    This study aimed to explore hyper-O-linked N-acetylglucosaminylation (O-GlcNAcylation) with an elevation of the expression of O-linked-β-N-acetylglucosamine transferase (OGT) in human bladder cancer.
    Authors:Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai and Xudong Yao
    Citation:BMC Cancer 2018 18:1141
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