miércoles, 27 de febrero de 2019

BMC Cancer | Translational oncology

BMC Cancer | Translational oncology



Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.
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  1. Content Type:Research Article

    Previous studies have highlighted cytokine growth differentiation factor 15 (GDF-15) as a potential biomarker for digestive system tumors (DST). This study sought to assess the feasibility of using GDF-15 as a...
    Authors:Yanqiu Wang, Tao Jiang, Mingyan Jiang and Shuijing Gu
    Citation:BMC Cancer 2019 19:177
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  2. Content Type:Research Article

    The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, brea...
    Authors:Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert and Matthias Kappler
    Citation:BMC Cancer 2019 19:155
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  3. Content Type:Research Article

    Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the progno...
    Authors:Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt and Torben F. Hansen
    Citation:BMC Cancer 2019 19:142
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  5. Content Type:Research Article

    Tumor-infiltrating lymphocytes (TILs) are described as an important immune modulator in the tumor microenvironment and are associated with breast cancer (BC) outcome. The spatial analysis of TILs and TIL subty...
    Authors:Lisa König, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer and Agnes Bankfalvi
    Citation:BMC Cancer 2019 19:120
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  6. Content Type:Research Article

    In recent years, PD-1/PD-L1 immune checkpoint inhibitors have improved cancer therapy in many tumor types, but no benefit of immune checkpoint therapy has been found in glioblastoma multiforme (GBM). Based on ...
    Authors:Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell and Dieter Henrik Heiland
    Citation:BMC Cancer 2019 19:117
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  7. Content Type:Research Article

    Metastatic breast cancer (MBC) prognosis is variable, depending on several clinical and biological factors. A better prediction of a patient’s outcome could allow for a more accurate choice of treatments. The ...
    Authors:Amélie Darlix, Christophe Hirtz, Simon Thezenas, Aleksandra Maceski, Audrey Gabelle, Evelyne Lopez-Crapez, Hélène De Forges, Nelly Firmin, Séverine Guiu, William Jacot and Sylvain Lehmann
    Citation:BMC Cancer 2019 19:110
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  8. Content Type:Research Article

    MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker. Although fluorescence in situ hybridizati...
    Authors:Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman and Natarajan Aravindan
    Citation:BMC Cancer 2019 19:106
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  9. Content Type:Research Article

    Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological hete...
    Authors:Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang and Yuan Yuan
    Citation:BMC Cancer 2019 19:96
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  10. Content Type:Research Article

    Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival ...
    Authors:Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan and Adam A. Sabile
    Citation:BMC Cancer 2019 19:83
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  11. Content Type:Research Article

    Cancer is a life-threatening disease that causes every fourth death. It is often hard to determine the time point of progression. Therefore, biomarkers for cancer entities that indicate disease progression or ...
    Authors:Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader and Andrea U. Steinbicker
    Citation:BMC Cancer 2019 19:74
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  13. Content Type:Research Article

    The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association b...
    Authors:Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević and Tatjana Stanojković
    Citation:BMC Cancer 2019 19:71
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  14. Content Type:Research Article

    Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular sig...
    Authors:Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen and Joseph T. Chang
    Citation:BMC Cancer 2019 19:64
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  15. Content Type:Research Article

    Poly (ADP-ribose) polymerase inhibitors (PARPi) have become the first targeted therapies available in the treatment of patients with high-grade serous ovarian cancer (HGSOC). We recently described a significan...
    Authors:Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen and Walter H. Gotlieb
    Citation:BMC Cancer 2019 19:44
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  16. Content Type:Research Article

    Findings remain unclear whether neutrophil-to-lymphocyte ratio (NLR) detrimentally affects advanced nasopharyngeal carcinoma (NPC) prognosis. We aim to evaluate the prognostic value of NLR in patients with NPC...
    Authors:Ji-Jin Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen, Wang-Jian Zhang, Wayne R. Lawrence, Fan Zhang, Si-Yang Wang, Ying Sun and Guan-Qun Zhou
    Citation:BMC Cancer 2019 19:37
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  17. Content Type:Research Article

    Metastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. Previous studies have proved the prog...
    Authors:Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang and Wenhua Li
    Citation:BMC Cancer 2019 19:15
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  18. Content Type:Research Article

    Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for ...
    Authors:Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro and Rosa Noguera
    Citation:BMC Cancer 2019 19:1
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  19. Content Type:Research Article

    Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,
    Authors:Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani and Seyed Abdolrahim Rezaee
    Citation:BMC Cancer 2018 18:1287
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  21. Content Type:Research Article

    Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tum...
    Authors:Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke and David Anz
    Citation:BMC Cancer 2018 18:1278
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  22. Content Type:Research Article

    Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangement in tissue specimens has been approved by US FDA (Food and Drug Administration) to select treatment for non–small-cell lung ca...
    Authors:Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao and Zhi Hui Zhang
    Citation:BMC Cancer 2018 18:1277
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  23. Content Type:Research Article

    Definite prognostic clinical factors of benefit for decitabine-based induction chemotherapy in elderly patients newly diagnosed with acute myeloid leukaemia (AML) are not identified. This study was designed to...
    Authors:Jiayu Huang, Huihui Zhao, Ming Hong, Han Zhu, Yu Zhu, Yun Lian, Shan Li, Jianyong Li and Sixuan Qian
    Citation:BMC Cancer 2018 18:1269
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  24. Content Type:Technical Advance

    Clinical assays for the assessment of the human epidermal growth factor receptor-2 (HER2) status in breast cancer include immunohistochemistry (IHC) and in situ hybridization (ISH), both of which have limitati...
    Authors:David G. Hicks, Brandon Buscaglia, Hideki Goda, Loralee McMahon, Takako Natori, Bradley Turner, Armen Soukiazian, Hisatake Okada and Yasushi Nakano
    Citation:BMC Cancer 2018 18:1266
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  25. Content Type:Research Article

    Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, ...
    Authors:Yang Bai, Liang-Dong Li, Jun Li and Xin Lu
    Citation:BMC Cancer 2018 18:1256
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  26. Content Type:Research Article

    Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs) will relapse if treatment is withdrawn, but various trials have recently demonstrated that a significant proport...
    Authors:Nuno Cerveira, Bruno Loureiro, Susana Bizarro, Cecília Correia, Lurdes Torres, Susana Lisboa, Joana Vieira, Rui Santos, Dulcineia Pereira, Cláudia Moreira, Sérgio Chacim, Nélson Domingues, Ana Espírito-Santo, Isabel Oliveira, Ilídia Moreira, Luísa Viterbo…
    Citation:BMC Cancer 2018 18:1245
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  27. Content Type:Research Article

    SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppress...
    Authors:Hyunsung Kim, Yeseul Kim, Yumin Chung, Rehman Abdul, Jongmin Sim, Hyein Ahn, Su-Jin Shin, Seung Sam Paik, Han Joon Kim, Kiseok Jang and Dongho Choi
    Citation:BMC Cancer 2018 18:1244
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  28. Content Type:Research Article

    The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-...
    Authors:Akihiro Yoshimura, Tadaaki Yamada, Naoko Okura, Takayuki Takeda, Wataru Furutani, Yutaka Kubota, Shinsuke Shiotsu, Osamu Hiranuma, Naoya Nishioka, Yusuke Chihara, Nobuyo Tamiya, Yoshiko Kaneko, Junji Uchino and Koichi Takayama
    Citation:BMC Cancer 2018 18:1241
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  29. Content Type:Research Article

    EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural e...
    Authors:Jong Sik Lee, Jae Young Hur, In Ae Kim, Hee Joung Kim, Chang Min Choi, Jae Chol Lee, Wan Seop Kim and Kye Young Lee
    Citation:BMC Cancer 2018 18:1236
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  31. Content Type:Research Article

    Prognostic factors in breast cancer are often measured on a continuous scale, but categorized for clinical decision-making. The primary aim of this study was to evaluate if accounting for continuous non-linear...
    Authors:Carina Forsare, Martin Bak, Anna-Karin Falck, Dorthe Grabau, Fredrika Killander, Per Malmström, Lisa Rydén, Olle Stål, Marie Sundqvist, Pär-Ola Bendahl and Mårten Fernö
    Citation:BMC Cancer 2018 18:1226
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  32. Content Type:Research Article

    Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Bec...
    Authors:Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru and Dominique Tierny
    Citation:BMC Cancer 2018 18:1219
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  33. Content Type:Research Article

    The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid can...
    Authors:Maryam Zarkesh, Azita Zadeh-Vakili, Mahdi Akbarzadeh, S. Ahmad Fanaei, Mehdi Hedayati and Fereidoun Azizi
    Citation:BMC Cancer 2018 18:1199
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  34. Content Type:Research Article

    A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, ho...
    Authors:Martina Schmitz, Kristin Eichelkraut, Dana Schmidt, Ilona Zeiser, Ziad Hilal, Zena Tettenborn, Alfred Hansel and Hans Ikenberg
    Citation:BMC Cancer 2018 18:1197
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  35. Content Type:Research Article

    The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by non-invasive cells, particularly by cells from ductal c...
    Authors:Yasamin Al-Qassab, Silvia Grassilli, Federica Brugnoli, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo
    Citation:BMC Cancer 2018 18:1194
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  36. Content Type:Research Article

    Recently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in variou...
    Authors:Donghua Huang, Yizhong Peng, Kaige Ma, Xiangyu Deng, Lu Tang, Doudou Jing and Zengwu Shao
    Citation:BMC Cancer 2018 18:1189
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  37. Content Type:Research Article

    Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage in the course of disease and therefore carr...
    Authors:Yunhong Tian, Jianlin Wu, Cristian Chagas, Yichao Du, Huan Lyu, Yunhong He, Shouliang Qi, Yong Peng and Jiani Hu
    Citation:BMC Cancer 2018 18:1187
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  38. Content Type:Research Article

    The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 and CRP, AC score) levels and to evaluate the prognostic value of ...
    Authors:Minjie Mao, Xueping Wang, Hui Sheng, Yijun Liu, Lin Zhang, Shuqin Dai and Pei-dong Chi
    Citation:BMC Cancer 2018 18:1178
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  39. Content Type:Research Article

    Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this stu...
    Authors:Rui-Lian Chen, Jun Zhao, Xu-Chao Zhang, Na-Na Lou, Hua-Jun Chen, Xue Yang, Jian Su, Zhi Xie, Qing Zhou, Hai-Yan Tu, Wen-Zhao Zhong, Hong-Hong Yan, Wei-Bang Guo, Yi-Long Wu and Jin-Ji Yang
    Citation:BMC Cancer 2018 18:1171
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  40. Content Type:Case Report

    Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (...
    Authors:Philippe Rochigneux, Jeanne Thomassin-Piana, Sophy Laibe, Serge Brunelle, Naji Salem, Bernard Escudier, Gilles Vassal and Gwenaelle Gravis
    Citation:BMC Cancer 2018 18:1159
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  41. Content Type:Research Article

    Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising targets in the therapy of advanced non-small cell lung cancer (NSCLC) and are predominantly detected by immunohistochemistry (IHC)...
    Authors:Claudia Vollbrecht, Dido Lenze, Michael Hummel, Annika Lehmann, Markus Moebs, Nikolaj Frost, Philipp Jurmeister, Leonille Schweizer, Udo Kellner, Manfred Dietel and Maximilian von Laffert
    Citation:BMC Cancer 2018 18:1158
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  42. Content Type:Research Article

    Drug-drug interactions (DDIs) in subjects enrolling in clinical trials can impact not only safety of the patient but also study drug outcomes and data validity. This makes it critical to adequately screen and ...
    Authors:Lauren A. Marcath, Taylor D. Coe, Emily K. Hoylman, Bruce G. Redman and Daniel L. Hertz
    Citation:BMC Cancer 2018 18:1155
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  43. Content Type:Research Article

    Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in the biology and outcome of a high-risk subset of newly diagnosed multiple myeloma (nMM), this ...
    Authors:Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang and Siegfried Janz
    Citation:BMC Cancer 2018 18:1152
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  44. Content Type:Research Article

    On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer...
    Authors:Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami and Yoshinobu Ohsaki
    Citation:BMC Cancer 2018 18:1136
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  45. Content Type:Research Article

    Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...
    Authors:Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin and Nianyong Chen
    Citation:BMC Cancer 2018 18:1133
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  46. Content Type:Research Article

    Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...
    Authors:Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park
    Citation:BMC Cancer 2018 18:1103
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  47. Content Type:Research Article

    Inter-patient heterogeneity in radiation-induced DNA damage responses is proposed to reflect intrinsic variations in tumour and normal tissue radiation sensitivity, but the prediction of phenotype by a molecul...
    Authors:Kevin Lee Min Chua, Eugenia Li Ling Yeo, Waseem Ahamed Shihabudeen, Sze Huey Tan, Than Than Shwe, Enya Hui Wen Ong, Paula Yeng Po Lam, Khee Chee Soo, Yoke Lim Soong, Kam Weng Fong, Terence Wee Kiat Tan, Joseph Tien Seng Wee and Melvin Lee Kiang Chua
    Citation:BMC Cancer 2018 18:1095
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  48. Content Type:Research Article

    Development of chemo−/radioresistance is a major challenge for the current prostate cancer (CaP) therapy. We have previously demonstrated that epithelial cell adhesion molecule (EpCAM) is associated with CaP g...
    Authors:Jie Ni, Paul Cozzi, Julia Beretov, Wei Duan, Joseph Bucci, Peter Graham and Yong Li
    Citation:BMC Cancer 2018 18:1092
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  49. Content Type:Research Article

    Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX (PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be hypo...
    Authors:Daniel Riani Gotardelo, Lilia Coronato Courrol, Maria Helena Bellini, Flávia Rodrigues de Oliveira Silva and Carlos Roberto Jorge Soares
    Citation:BMC Cancer 2018 18:1090
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  50. Content Type:Research Article

    Invasive micropapillary carcinoma (IMPC) is an unusual and distinct subtype of invasive breast tumor with high propensity for regional lymph node metastases. This study was to identify risk factors accounting ...
    Authors:Fu-Gui Ye, Chen Xia, Ding Ma, Pei-Yang Lin, Xin Hu and Zhi-Ming Shao
    Citation:BMC Cancer 2018 18:1085
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