jueves, 26 de diciembre de 2019

Acta Neuropathologica Communications | Articles

Acta Neuropathologica Communications | Articles

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  1. Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recen...
    Authors:Diego Perez-Rodriguez, Maria Kalyva, Melissa Leija-Salazar, Tammaryn Lashley, Maxime Tarabichi, Viorica Chelban, Steve Gentleman, Lucia Schottlaender, Hannah Franklin, George Vasmatzis, Henry Houlden, Anthony H. V. Schapira, Thomas T. Warner, Janice L. Holton, Zane Jaunmuktane and Christos Proukakis
    Citation:Acta Neuropathologica Communications 2019 7:219
    Content type:Research
    Published on: 
  2. Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause f...
    Authors:Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley and Erik D. Roberson
    Citation:Acta Neuropathologica Communications 2019 7:218
    Content type:Research
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  3. Perioperative sleep disturbance is a risk factor for persistent pain after surgery. Clinical studies have shown that patients with insufficient sleep before and after surgery experience more intense and long-l...
    Authors:Qi Li, Zi-yu Zhu, Jian Lu, Yu-Chieh Chao, Xiao-xin Zhou, Ying Huang, Xue-mei Chen, Dian-san Su, Wei-feng Yu and Xi-yao Gu
    Citation:Acta Neuropathologica Communications 2019 7:217
    Content type:Research
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  4. The development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic m...
    Authors:Daniela Talhada, Joana Feiteiro, Ana Raquel Costa, Tiago Talhada, Elisa Cairrão, Tadeusz Wieloch, Elisabet Englund, Cecília Reis Santos, Isabel Gonçalves and Karsten Ruscher
    Citation:Acta Neuropathologica Communications 2019 7:216
    Content type:Research
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  5. Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and regulator of lysosomal f...
    Authors:Anarmaa Mendsaikhan, Ikuo Tooyama, Jean-Pierre Bellier, Geidy E. Serrano, Lucia I. Sue, Lih-Fen Lue, Thomas G. Beach and Douglas G. Walker
    Citation:Acta Neuropathologica Communications 2019 7:215
    Content type:Research
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  6. Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic r...
    Authors:Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart and Tara L. Spires-Jones
    Citation:Acta Neuropathologica Communications 2019 7:214
    Content type:Research
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  7. Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF in...
    Authors:Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Cristine Betzer, Jervis Vermal Thevathasan, Robin Diekmann, Mohamed Adel, Nisreen Mansour Omar, Mohamed Z. Boraie, Sabry Gad, Jonas Ries, Deniz Kirik, Sadegh Nabavi and Poul Henning Jensen
    Citation:Acta Neuropathologica Communications 2019 7:213
    Content type:Methodology article
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  8. Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a...
    Authors:Katja Thümmler, Eran Rom, Thomas Zeis, Maren Lindner, Sarah Brunner, John J. Cole, Diana Arseni, Steve Mücklisch, Julia M. Edgar, Nicole Schaeren-Wiemers, Avner Yayon and Christopher Linington
    Citation:Acta Neuropathologica Communications 2019 7:212
    Content type:Research
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  9. Congenital myopathies (CM) form a genetically heterogeneous group of disorders characterized by perinatal muscle weakness. Here, we report an 11-year old male offspring of consanguineous parents of Lebanese or...
    Authors:Hormos Salimi Dafsari, Nur Mehpare Kocaturk, Hülya-Sevcan Daimagüler, Anna Brunn, Jörg Dötsch, Joachim Weis, Martina Deckert and Sebahattin Cirak
    Citation:Acta Neuropathologica Communications 2019 7:211
    Content type:Case report
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  10. Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD). Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits...
    Authors:Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P. Jesper Sjöström and Andrea C. LeBlanc
    Citation:Acta Neuropathologica Communications 2019 7:210
    Content type:Research
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  11. Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense transcripts of the expansions ar...
    Authors:Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke and Linda Partridge
    Citation:Acta Neuropathologica Communications 2019 7:209
    Content type:Research
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  12. Variations in the POLG1 gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma, have recently been associated with Parkinson’s disease (PD), especially in patients diagnosed with progres...
    Authors:Margarita Chumarina, Kaspar Russ, Carla Azevedo, Andreas Heuer, Maria Pihl, Anna Collin, Eleonor Åsander Frostner, Eskil Elmer, Poul Hyttel, Graziella Cappelletti, Michela Zini, Stefano Goldwurm and Laurent Roybon
    Citation:Acta Neuropathologica Communications 2019 7:208
    Content type:Case report
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  13. Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative condition associated with repetitive traumatic brain injury (rTBI) seen in contact-sport athletes and military personnel. The medial te...
    Authors:Christy M. Kelley, Sylvia E. Perez and Elliott J. Mufson
    Citation:Acta Neuropathologica Communications 2019 7:207
    Content type:Research
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  14. Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between AL...
    Authors:Amit U. Joshi, Lauren D. Van Wassenhove, Kelsey R. Logas, Paras S. Minhas, Katrin I. Andreasson, Kenneth I. Weinberg, Che-Hong Chen and Daria Mochly-Rosen
    Citation:Acta Neuropathologica Communications 2019 7:190
    Content type:Research
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  15. Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in young adults, pathologically characterized by leukocyte infiltration of the central nervous system, demyelination of the ...
    Authors:Thecla A. van Wageningen, Eva Vlaar, Gijs Kooij, Cornelis A. M. Jongenelen, Jeroen J. G. Geurts and Anne-Marie van Dam
    Citation:Acta Neuropathologica Communications 2019 7:206
    Content type:Research
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  16. To identify pathogenetic markers and potential drivers of different lesion types in the white matter (WM) of patients with progressive multiple sclerosis (PMS), we sequenced RNA from 73 different WM areas. Com...
    Authors:Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach and Zsolt Illes
    Citation:Acta Neuropathologica Communications 2019 7:205
    Content type:Research
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  17. Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs). Recently, primary age-related tauopa...
    Authors:Miguel Quintas-Neves, Merilee A. Teylan, Lilah Besser, João Soares-Fernandes, Charles N. Mock, Walter A. Kukull, John F. Crary and Tiago Gil Oliveira
    Citation:Acta Neuropathologica Communications 2019 7:204
    Content type:Research
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  18. Many mouse models of Alzheimer’s disease (AD) exhibit impairments in hippocampal long-term-potentiation (LTP), seemingly corroborating the strong correlation between synaptic loss and cognitive decline reporte...
    Authors:Enrico Faldini, Tariq Ahmed, Luc Bueé, David Blum and Detlef Balschun
    Citation:Acta Neuropathologica Communications 2019 7:202
    Content type:Research
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  19. The presence of genome-wide DNA hypermethylation is a hallmark of lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) mutations. Further molecular classification of IDH mutant gliomas is defined by t...
    Authors:Ruslan Al-Ali, Katharina Bauer, Jong-Whi Park, Ruba Al Abdulla, Valentina Fermi, Andreas von Deimling, Christel Herold-Mende, Jan-Philipp Mallm, Carl Herrmann, Wolfgang Wick and Şevin Turcan
    Citation:Acta Neuropathologica Communications 2019 7:201
    Content type:Research
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  20. Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic proc...
    Authors:Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni and Christopher C. J. Miller
    Citation:Acta Neuropathologica Communications 2019 7:200
    Content type:Research
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  21. CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutation...
    Authors:Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik…
    Citation:Acta Neuropathologica Communications 2019 7:199
    Content type:Research
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  22. Aβ-amyloid deposition is a key feature of Alzheimer’s disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships...
    Authors:S. B. Wharton, D. Wang, C. Parikh, F. E. Matthews, C. Brayne and P. G. Ince
    Citation:Acta Neuropathologica Communications 2019 7:198
    Content type:Research
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  23. Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and agg...
    Authors:Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo and Conrad C. Weihl
    Citation:Acta Neuropathologica Communications 2019 7:197
    Content type:Research
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  24. Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Clco-transporter 2 (KCC2) expression is suggested to play a key role in the...
    Authors:Lisa Hinz, Joan Torrella Barrufet and Vivi M. Heine
    Citation:Acta Neuropathologica Communications 2019 7:196
    Content type:Case report
    Published on: 
  25. We recently identified Secernin-1 (SCRN1) as a novel amyloid plaque associated protein using localized proteomics. Immunohistochemistry studies confirmed that SCRN1 was present in plaque-associated dystrophic ...
    Authors:Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, Glenda Halliday, Marie-Claude Potier, Thomas Wisniewski and Eleanor Drummond
    Citation:Acta Neuropathologica Communications 2019 7:195
    Content type:Research
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  26. An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer’s disease (AD). Amyloid degradation is mediated by various mechanisms including fragm...
    Authors:Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M. Nitsch, Gerhard Multhaup and Luka Kulic
    Citation:Acta Neuropathologica Communications 2019 7:194
    Content type:Research
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  27. Synucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclei...
    Authors:Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson and Michel Goedert
    Citation:Acta Neuropathologica Communications 2019 7:193
    Content type:Research
    Published on: 
  28. Tau is a microtubule-binding protein that can receive various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. ...
    Authors:Ebru Ercan-Herbst, Jens Ehrig, David C. Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber and Dagmar E. Ehrnhoefer
    Citation:Acta Neuropathologica Communications 2019 7:192
    Content type:Research
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  29. The contribution of mosaic alterations to tumors of the nervous system and to non-malignant neurological diseases has been unmasked thanks to the development of Next Generation Sequencing (NGS) technologies. W...
    Authors:Alice Goldenberg, Florent Marguet, Vianney Gilard, Aude-Marie Cardine, Adnan Hassani, François Doz, Sophie Radi, Stéphanie Vasseur, Jacqueline Bou, Maud Branchaud, Claude Houdayer, Stéphanie Baert-Desurmont, Annie Laquerriere and Thierry Frebourg
    Citation:Acta Neuropathologica Communications 2019 7:191
    Content type:Case report
    Published on: 
  30. Motor-, behavior- and/or cognition-related symptoms are key hallmarks in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with TDP-43 pathology (FTLD-TDP), respect...
    Authors:Lieselot Dedeene, Evelien Van Schoor, Rik Vandenberghe, Philip Van Damme, Koen Poesen and Dietmar Rudolf Thal
    Citation:Acta Neuropathologica Communications 2019 7:189
    Content type:Research
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  31. Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive the development of brain tumors such as glioblast...
    Authors:Maria Martinez-Lage, Timothy M. Lynch, Yingtao Bi, Carolina Cocito, Gregory P. Way, Sharmistha Pal, Josephine Haller, Rachel E. Yan, Amy Ziober, Aivi Nguyen, Manoj Kandpal, Donald M. O’Rourke, Jeffrey P. Greenfield, Casey S. Greene, Ramana V. Davuluri and Nadia Dahmane
    Citation:Acta Neuropathologica Communications 2019 7:203
    Content type:Research
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  32. Swedish type Hereditary Diffuse Leukoencephalopathy with Spheroids (HDLS-S) is a severe adult-onset leukoencephalopathy with the histopathological hallmark of neuraxonal degeneration with spheroids, described ...
    Authors:Christina Sundal, Susana Carmona, Maria Yhr, Odd Almström, Maria Ljungberg, John Hardy, Carola Hedberg-Oldfors, Åsa Fred, José Brás, Anders Oldfors, Oluf Andersen and Rita Guerreiro
    Citation:Acta Neuropathologica Communications 2019 7:188
    Content type:Research
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  33. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic paradigm of small vessel disease (SVD) caused by NOTCH3 mutations that stereotypically lead to the...
    Authors:Rikesh M. Rajani, Julien Ratelade, Valérie Domenga-Denier, Yoshiki Hase, Hannu Kalimo, Raj N. Kalaria and Anne Joutel
    Citation:Acta Neuropathologica Communications 2019 7:187
    Content type:Research
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  34. Numerous clinical studies have established the debilitating neurocognitive side effects of chemotherapy in the treatment of breast cancer, often referred as chemobrain. We hypothesize that cognitive impairment...
    Authors:Barrett D. Allen, Lauren A. Apodaca, Amber R. Syage, Mineh Markarian, Al Anoud D. Baddour, Harutyun Minasyan, Leila Alikhani, Celine Lu, Brian L. West, Erich Giedzinski, Janet E. Baulch and Munjal M. Acharya
    Citation:Acta Neuropathologica Communications 2019 7:186
    Content type:Research
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  35. Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomarkers for many drugs makes tar...
    Authors:Krissie Lenting, Corina N. A. M. van den Heuvel, Anne van Ewijk, Duaa ElMelik, Remco de Boer, Elizabeth Tindall, Ge Wei, Benno Kusters, Maarten te Dorsthorst, Mark ter Laan, Martijn A. Huynen and William P. Leenders
    Citation:Acta Neuropathologica Communications 2019 7:185
    Content type:Research
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  36. Targeting alpha-synuclein (α-syn) as a therapeutic strategy for Parkinson’s disease (PD) has been intensively pursued largely due to its well-recognized pathogenic role. Since its discovery as the first famili...
    Authors:Rebecca Z. Fan, Min Guo, Shouqing Luo, Mei Cui and Kim Tieu
    Citation:Acta Neuropathologica Communications 2019 7:184
    Content type:Research
    Published on: 
  37. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). While the clinical presentation of LRRK2 mutation carriers is similar to that of idiopathic PD (iP...
    Authors:Michael X. Henderson, Medha Sengupta, John Q. Trojanowski and Virginia M. Y. Lee
    Citation:Acta Neuropathologica Communications 2019 7:183
    Content type:Research
    Published on: 
  38. Mild traumatic brain injury (mTBI) leads to diverse symptoms including mood disorders, cognitive decline, and behavioral changes. In some individuals, these symptoms become chronic and persist in the long-term...
    Authors:Nicole Schwab, Karl Grenier and Lili-Naz Hazrati
    Citation:Acta Neuropathologica Communications 2019 7:182
    Content type:Research
    Published on: 
  39. Risk stratification of children with ependymomas of the posterior fossa in current therapeutic protocols is mainly based on clinical criteria. We aimed to identify independent outcome predictors for this disea...
    Authors:Stephanie T. Jünger, Martin Mynarek, Inken Wohlers, Evelyn Dörner, Anja zur Mühlen, Natalia Velez-Char, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Beate Timmermann, Sven Rahmann, Ludger Klein-Hitpass, Andre O. von Bueren and Torsten Pietsch
    Citation:Acta Neuropathologica Communications 2019 7:181
    Content type:Research
    Published on: 
  40. Alzheimer’s disease (AD) is the most common form of dementia in the elderly. According to the amyloid hypothesis, the accumulation and deposition of amyloid-beta (Aβ) peptides play a key role in AD. Soluble Aβ...
    Authors:Inès R. H. Ben-Nejma, Aneta J. Keliris, Jasmijn Daans, Peter Ponsaerts, Marleen Verhoye, Annemie Van der Linden and Georgios A. Keliris
    Citation:Acta Neuropathologica Communications 2019 7:180
    Content type:Research
    Published on: 
  41. In the original version of this article [1], there was 1 error in the affiliation of the European Institute of Oncology (affiliation 3). In this correction article the updated affiliation is shown for clarific...
    Authors:Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens and Silvia Marino
    Citation:Acta Neuropathologica Communications 2019 7:179
    Content type:Correction
    Published on: 
    The original article was published in Acta Neuropathologica Communications 2019 7:95
  42. Alzheimer’s disease (AD)-related amyloid β-peptide (Aβ) pathology in the form of amyloid plaques and cerebral amyloid angiopathy (CAA) spreads in its topographical distribution, increases in quantity, and unde...
    Authors:Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith…
    Citation:Acta Neuropathologica Communications 2019 7:178
    Content type:Research
    Published on: 
  43. Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into ...
    Authors:Kerstin Schlegel, Khader Awwad, Roland G. Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R. Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz and Laura Gasparini
    Citation:Acta Neuropathologica Communications 2019 7:177
    Content type:Research
    Published on: 
  44. Authors:Arnault Tauziède-Espariat, Mélanie Pagès, Alexandre Roux, Aurore Siegfried, Emmanuelle Uro-Coste, Yvan Nicaise, Annick Sevely, Marion Gambart, Sergio Boetto, Martin Dupuy, Pomone Richard, Romain Perbet, Matthieu Vinchon, Sabine Caron, Felipe Andreiuolo, Albane Gareton…
    Citation:Acta Neuropathologica Communications 2019 7:176
    Content type:Letter to the Editor
    Published on: 
  45. All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomer...
    Authors:Nathalie Grandin, Bruno Pereira, Camille Cohen, Pauline Billard, Caroline Dehais, Catherine Carpentier, Ahmed Idbaih, Franck Bielle, François Ducray, Dominique Figarella-Branger, Jean-Yves Delattre, Marc Sanson, Patrick Lomonte, Delphine Poncet, Pierre Verrelle and Michel Charbonneau
    Citation:Acta Neuropathologica Communications 2019 7:175
    Content type:Research
    Published on: 
  46. Microglial function is highly dependent on cell motility, with baseline motility required for homeostatic surveillance activity and directed motility to migrate towards a source of injury. Experimental evidenc...
    Authors:Diana K. Franco-Bocanegra, Bethany George, Laurie C. Lau, Clive Holmes, James A. R. Nicoll and Delphine Boche
    Citation:Acta Neuropathologica Communications 2019 7:174
    Content type:Research
    Published on: 
  47. Adolescent binge drinking represents a major public health challenge and can lead to persistent neurological and mental conditions, but the underlying pathogenic mechanisms remain poorly understood. Using a mo...
    Authors:James Rice, Laurence Coutellier, Jeffrey L. Weiner and Chen Gu
    Citation:Acta Neuropathologica Communications 2019 7:173
    Content type:Research
    Published on: 
  48. Non-tumoural cells within the tumour microenvironment (TME) influence tumour proliferation, invasiveness and angiogenesis. Little is known about TME in pituitary neuroendocrine tumours (PitNETs). We aimed to c...
    Authors:Pedro Marques, Sayka Barry, Eivind Carlsen, David Collier, Amy Ronaldson, Sherine Awad, Neil Dorward, Joan Grieve, Nigel Mendoza, Samiul Muquit, Ashley B. Grossman, Frances Balkwill and Márta Korbonits
    Citation:Acta Neuropathologica Communications 2019 7:172
    Content type:Research
    Published on: 
  49. The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the mechanisms underlying these pathologies. Luminescent conjugated oligo...
    Authors:Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Simon Dujardin, Hamid Shirani, K. Peter R. Nilsson and Brian J. Bacskai
    Citation:Acta Neuropathologica Communications 2019 7:171
    Content type:Research
    Published on: 
  50. Although it has been suggested that the co-expression of multiple pathological proteins associated with neurodegeneration may act synergistically to induce more widespread neuropathology, experimental evidence...
    Authors:Alexander J. Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J. Strong and Kathryn Volkening
    Citation:Acta Neuropathologica Communications 2019 7:170
    Content type:Research
    Published on: 

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