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Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies
To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with Alzheimer’s disease (MCI-AD) and (2) its utility as a potential ...Alzheimer's Research & Therapy 2020 12:82One third of dementia cases can be prevented within the next 25 years by tackling risk factors. The case “for” and “against”
Recently, it has been suggested that up to a third of the dementia cases might be preventable. While prevention is always better than cure, this is particularly important in the field of dementia, as current i...Alzheimer's Research & Therapy 2020 12:81Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD). Here,...Alzheimer's Research & Therapy 2020 12:80The insula, a grey matter of tastes: a volumetric MRI study in dementia with Lewy bodies
Despite the growing number of discoveries during the past decades about its functions, the insula remains a mysterious ‘island’. In addition to its involvement in basic functions such as gustation and interoce...Alzheimer's Research & Therapy 2020 12:79Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research
Growing awareness of Alzheimer’s disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memor...Alzheimer's Research & Therapy 2020 12:78Imaging the aging brain: study design and baseline findings of the SENIOR cohort
Current demographic trends point towards an aging society entailing increasing occurrence and burden of neurodegenerative diseases. In this context, understanding physiological aging and its turning point into...Alzheimer's Research & Therapy 2020 12:77The short-term effects of sedentary behaviour on cerebral hemodynamics and cognitive performance in older adults: a cross-over design on the potential impact of mental and/or physical activity
Sedentary behaviour might be a potential risk factor for cognitive decline. However, the short-term effects of sedentary behaviour on (cerebro) vascular and cognitive performance in older people are unknown.Alzheimer's Research & Therapy 2020 12:76Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
All cells accumulate insoluble protein aggregates throughout their lifespan. While many studies have characterized the canonical disease-associated protein aggregates, such as those associated with amyloid pla...Alzheimer's Research & Therapy 2020 12:75The dynamics of biomarkers across the clinical spectrum of Alzheimer’s disease
Quantifying changes in the levels of biological and cognitive markers prior to the clinical presentation of Alzheimer’s disease (AD) will provide a template for understanding the underlying aetiology of the cl...Alzheimer's Research & Therapy 2020 12:74Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases
The retina and the brain share anatomic, embryologic, and physiologic characteristics. Therefore, retinal imaging in patients with brain disorders has been of significant interest. Using optical coherence tomo...Alzheimer's Research & Therapy 2020 12:73Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology
Heme and iron homeostasis is perturbed in Alzheimer’s disease (AD); therefore, the aim of the study was to examine the levels and association of heme with iron-binding plasma proteins in cognitively normal (CN...Alzheimer's Research & Therapy 2020 12:72Correction to: Relevance of biomarkers across different neurodegenerative diseases
An amendment to this paper has been published and can be accessed via the original article.Alzheimer's Research & Therapy 2020 12:71The original article was published in Alzheimer's Research & Therapy 2020 12:56Young blood plasma reduces Alzheimer’s disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice
Recent studies indicated that circulatory factors in blood plasma from young animals can reactivate neurogenesis, restore synaptic plasticity, and improve cognitive function in aged animals. Here, we investiga...Alzheimer's Research & Therapy 2020 12:70Immediate and long-term consequences of COVID-19 infections for the development of neurological disease
Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, les...Alzheimer's Research & Therapy 2020 12:69Reproducibility of EEG functional connectivity in Alzheimer’s disease
Although numerous electroencephalogram (EEG) studies have described differences in functional connectivity in Alzheimer’s disease (AD) compared to healthy subjects, there is no general consensus on the methodo...Alzheimer's Research & Therapy 2020 12:68- Alzheimer's Research & Therapy 2020 12:67
The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease
There is growing interest in identifying sensitive composite cognitive tests to serve as primary endpoints in preclinical Alzheimer’s disease (AD) treatment trials. We reported previously a composite cognitive...Alzheimer's Research & Therapy 2020 12:66APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprote...Alzheimer's Research & Therapy 2020 12:65Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data
Our objectives were to develop a disease progression model for cognitive decline in Alzheimer’s disease (AD) and to determine whether disease progression of AD is related to the year of publication, add-on tri...Alzheimer's Research & Therapy 2020 12:64Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission
Alzheimer’s disease (AD) is the most common form of age-related neurodegenerative diseases. Cerebral deposition of Aβ peptides, especially Aβ42, is considered the major neuropathological hallmark of AD and the...Alzheimer's Research & Therapy 2020 12:63Physical exercise during exposure to 40-Hz light flicker improves cognitive functions in the 3xTg mouse model of Alzheimer’s disease
Exercise promotes brain health and improves cognitive functioning in the elderly, while 40-Hz light flickering through the visual cortex reduces amyloid beta (Aβ) by stabilizing gamma oscillation. We examined ...Alzheimer's Research & Therapy 2020 12:62γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous repo...Alzheimer's Research & Therapy 2020 12:61Is it time to use real-world data from primary care in Alzheimer’s disease?
The analysis of real-world data in clinical research is rising, but its use to study dementia subtypes has been hardly addressed. We hypothesized that real-world data might be a powerful tool to update AD epid...Alzheimer's Research & Therapy 2020 12:60Differential blood miRNA expression in brain amyloid imaging-defined Alzheimer’s disease and controls
Peripheral blood microRNAs (miRNA) have been identified as potential biomarkers for Alzheimer’s disease (AD). Study results have generally been inconsistent and limited by sample heterogeneity. The aim of this...Alzheimer's Research & Therapy 2020 12:59Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer’s disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study
Atabecestat, a potent brain-penetrable inhibitor of BACE1 activity that reduces CSF amyloid beta (Aβ), was developed for oral treatment for Alzheimer’s disease (AD).Alzheimer's Research & Therapy 2020 12:58The meta-memory ratio: a new cohort-independent way to measure cognitive awareness in asymptomatic individuals at risk for Alzheimer’s disease
Lack of awareness of cognitive decline (ACD) has been described at the preclinical and prodromal stages of Alzheimer’s disease (AD). In this study, we introduced a meta-memory ratio (MMR) and explored how it i...Alzheimer's Research & Therapy 2020 12:57Relevance of biomarkers across different neurodegenerative diseases
The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and incre...Alzheimer's Research & Therapy 2020 12:56The Correction to this article has been published in Alzheimer's Research & Therapy 2020 12:71Longitudinal trajectories of Alzheimer’s ATN biomarkers in elderly persons without dementia
Models of Alzheimer’s disease (AD) pathophysiology posit that amyloidosis [A] precedes and accelerates tau pathology [T] that leads to neurodegeneration [N]. Besides this A-T-N sequence, other biomarker sequen...Alzheimer's Research & Therapy 2020 12:55Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles
The contributions of brain intercellular communication mechanisms, specifically extracellular vesicles (EV), to the progression of Alzheimer’s disease (AD) remain poorly understood.Alzheimer's Research & Therapy 2020 12:54Correction to: Sleep dysregulation, memory impairment, and CSF biomarkers during different levels of neurocognitive functioning in Alzheimer’s disease course
An amendment to this paper has been published and can be accessed via the original article.Alzheimer's Research & Therapy 2020 12:53The original article was published in Alzheimer's Research & Therapy 2020 12:5Subjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea
Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea.Alzheimer's Research & Therapy 2020 12:52The cholinergic system in subtypes of Alzheimer’s disease: an in vivo longitudinal MRI study
The heterogeneity within Alzheimer’s disease (AD) seriously challenges the development of disease-modifying treatments. We investigated volume of the basal forebrain, hippocampus, and precuneus in atrophy subt...Alzheimer's Research & Therapy 2020 12:51The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease
Early-onset Alzheimer’s disease (EOAD) is characterized by young age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus differing significantly from typical late-onset Alzheim...Alzheimer's Research & Therapy 2020 12:50Imaging biomarkers in neurodegeneration: current and future practices
There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically for the in vivo investigati...Alzheimer's Research & Therapy 2020 12:49The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health
Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer’s disease (AD) continuum. Conversely, physical activity (PA) has been assoc...Alzheimer's Research & Therapy 2020 12:48Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice
Amyloid beta (Aβ) which is recognized as a main feature of Alzheimer’s disease (AD) has been proposed to “spread” through anatomically and functionally connected brain regions. The entorhinal cortex and perfor...Alzheimer's Research & Therapy 2020 12:47EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease
Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in ...Alzheimer's Research & Therapy 2020 12:46A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal cell loss, and cognitive impairment are pathological presentations of Alzheimer’s disease (AD). Therefore, resolution of neuroinflam...Alzheimer's Research & Therapy 2020 12:45Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is more prevalent in men than in women. In addition, post-mortem studies found sex differences in underlying pathology. It remains unclear whether these differences are also pre...Alzheimer's Research & Therapy 2020 12:44An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease
Genome-wide association studies (GWAS) have successfully identified multiple independent genetic loci that harbour variants associated with Alzheimer’s disease, but the exact causal genes and biological pathwa...Alzheimer's Research & Therapy 2020 12:43Are ketogenic diets promising for Alzheimer’s disease? A translational review
Brain amyloid deposition and neurofibrillary tangles in Alzheimer’s disease (AD) are associated with complex neuroinflammatory reactions such as microglial activation and cytokine production. Glucose metabolis...Alzheimer's Research & Therapy 2020 12:42Improving the resistance and resilience framework for aging and dementia studies
The "resistance vs resilience" to Alzheimer’s disease (AD) framework (coping vs avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to provide clarity to the usage...Alzheimer's Research & Therapy 2020 12:41Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer’s disease and type 2 diabetes
Both Alzheimer’s disease (AD) and type 2 diabetes (T2D) share common pathological features including inflammation, insulin signaling alterations, or vascular damage. AD has no successful treatment, and the clo...Alzheimer's Research & Therapy 2020 12:40Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment
The Montreal Cognitive Assessment (MoCA) has good sensitivity for mild cognitive impairment, but specificity is low when the original cut-off (25/26) is used. We aim to revise the cut-off on the German MoCA fo...Alzheimer's Research & Therapy 2020 12:39Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study
Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk.Alzheimer's Research & Therapy 2020 12:38Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative
Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer’s disease (AD...Alzheimer's Research & Therapy 2020 12:37Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging
β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of Alzheimer’s disease (AD). However, numerous researc...Alzheimer's Research & Therapy 2020 12:36Neuropsychiatric symptoms in cognitively normal older persons, and the association with Alzheimer’s and non-Alzheimer’s dementia
Neuropsychiatric symptoms (NPS) have been reported to be useful in predicting incident dementia among cognitively normal older persons. However, the literature has not been conclusive on the differential utili...Alzheimer's Research & Therapy 2020 12:35In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology
TDP-43 type C is one of the pathological forms of frontotemporal lobar degeneration (FTLD) and mainly associated clinically with the semantic variant of primary progressive aphasia (svPPA). We aimed to define ...Alzheimer's Research & Therapy 2020 12:34
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