Neuroprotective effects of magnesium l-threonate in a hypoxic zebrafish model
Hypoxia inhibits the uptake of glutamate (a major neurotransmitter in the brain closely related to cognitive function) into brain cells, and the initial response of cells to cortical hypoxia depends on glutama...BMC Neuroscience 2020 21:29NeuroConstruct-based implementation of structured-light stimulated retinal circuitry
Retinal circuitry provides a fundamental window to neural networks, featuring widely investigated visual phenomena ranging from direction selectivity to fast detection of approaching motion. As the divide betw...BMC Neuroscience 2020 21:28Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain
Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper brain development and function. The HCFC1 gene encodes a transcriptional co-factor that regulates ...BMC Neuroscience 2020 21:27Anodal transcranial direct current stimulation reduces motor slowing in athletes and non-athletes
Motor fatigability describes a phenomenon that occurs when exhaustive exercise or physically demanding tasks are executed over an extended period of time. Concerning fast repetitive movements, it is noticeable...BMC Neuroscience 2020 21:26Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6)
Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...BMC Neuroscience 2020 21:25Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage
Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...BMC Neuroscience 2020 21:24Alexithymia and automatic processing of facial emotions: behavioral and neural findings
Alexithymia is a personality trait characterized by difficulties identifying and describing feelings, an externally oriented style of thinking, and a reduced inclination to imagination. Previous research has s...BMC Neuroscience 2020 21:23Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock
Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...BMC Neuroscience 2020 21:22Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke
Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, w...BMC Neuroscience 2020 21:21The impact of mental fatigue on brain activity: a comparative study both in resting state and task state using EEG
Mental fatigue is usually caused by long-term cognitive activities, mainly manifested as drowsiness, difficulty in concentrating, decreased alertness, disordered thinking, slow reaction, lethargy, reduced work...BMC Neuroscience 2020 21:20Conformity-like behaviour in mice observing the freezing of other mice: a model of empathy
Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empath...BMC Neuroscience 2020 21:19COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation
Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...BMC Neuroscience 2020 21:18Correction to: The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats
An amendment to this paper has been published and can be accessed via the original article.BMC Neuroscience 2020 21:17The original article was published in BMC Neuroscience 2020 21:15Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex
This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–D...BMC Neuroscience 2020 21:16The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats
Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves ...BMC Neuroscience 2020 21:15When gratitude and cooperation between friends affect inter-brain connectivity for EEG
Recently several studies in the psychological and social field have investigated the social function of gift exchange as a useful way for the consolidation of interpersonal and social relationships and the imp...BMC Neuroscience 2020 21:14Intravenous methylprednisolone or immunoglobulin for anti-glutamic acid decarboxylase 65 antibody autoimmune encephalitis: which is better?
Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...BMC Neuroscience 2020 21:13Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks
Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...BMC Neuroscience 2020 21:12Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs
Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.BMC Neuroscience 2020 21:11Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia
Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this ...BMC Neuroscience 2020 21:10The original article was published in BMC Neuroscience 2012 13:144Neuromyelitis optica: a pilot study of clinical presentation and status of serological biomarker AQP4 among patients admitted to a tertiary centre in NCNS, Sudan
Neuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquapor...BMC Neuroscience 2020 21:9Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice
There has been much discussion recently about the occurrence of neuropsychological complications during the perioperative period. Diabetes is known to be one of the metabolic risk factors. Although the number ...BMC Neuroscience 2020 21:8Identifying the pulsed neuron networks’ structures by a nonlinear Granger causality method
It is a crucial task of brain science researches to explore functional connective maps of Biological Neural Networks (BNN). The maps help to deeply study the dominant relationship between the structures of the...BMC Neuroscience 2020 21:7Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain
Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by...BMC Neuroscience 2020 21:6Sexual dimorphism following in vitro ischemia in the response to neurosteroids and mechanisms of injury
Cerebral ischemic stroke is a significant cause of morbidity and mortality. Sex differences exist following stroke in terms of incidence, symptoms, outcomes and response to some treatments. Importantly, molecu...BMC Neuroscience 2020 21:5Carbonyl-protein content increases in brain and blood of female rats after chronic oxycodone treatment
Opioids are the most effective drugs commonly prescribed to treat pain. Due to their addictive nature, opioid pain relievers are now second to marijuana, ahead of cocaine with respect to dependence. Ours and o...BMC Neuroscience 2020 21:4Capturing multiple interaction effects in L1 and L2 object-naming reaction times in healthy bilinguals: a mixed-effects multiple regression analysis
It is difficult to set up a balanced higher-order full-factorial experiment that can capture multiple intricate interactions between cognitive and psycholinguistic factors underlying bilingual speech productio...BMC Neuroscience 2020 21:3Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys
Aged rhesus monkeys exhibit deficits in memory mediated by the hippocampus. Although extensive research has been carried out on the characteristics of human hippocampal aging, there is still very little scient...BMC Neuroscience 2020 21:2Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress
Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, a member of the vitamin B compl...BMC Neuroscience 2020 21:1Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study
The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) duri...BMC Neuroscience 2019 20:66The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression
Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known. HDAC3 is known to be...BMC Neuroscience 2019 20:65Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage
Infection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.BMC Neuroscience 2019 20:64Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells
Autophagy is considered to be another restorative focus for the treatment of brain tumors. Although several research have demonstrated that melatonin induces autophagy in colon cancer and hepatoma cells, there...BMC Neuroscience 2019 20:63Amiodarone exacerbates brain injuries after hypoxic–ischemic insult in mice
Sodium ion transportation plays a crucial role in the pathogenesis of hypoxic–ischemic brain injury. Amiodarone, a Vaughan-Williams class III antiarrhythmic drug, has been widely used to treat life-threatening...BMC Neuroscience 2019 20:62Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease
Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new...BMC Neuroscience 2019 20:61Ketamine affects the integration of developmentally generated granule neurons in the adult stage
Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have been conducted to study the mechanism of neurotoxicity for general anesthetic use durin...BMC Neuroscience 2019 20:60LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides
The aim was to examine the impact of lipopolysaccharide-induced systemic inflammation on expression of mRNA for cocaine- and amphetamine-regulated transcript (CART) and the thyrotropin receptor (TSHR) and its ...BMC Neuroscience 2019 20:59Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures
The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic effects. Although each of these molecules effectively reduce the activity...BMC Neuroscience 2019 20:58Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system
Mammalian Shc (Src homology and collagen) proteins comprise a family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal expression and signaling functions. ShcD is the most recently ...BMC Neuroscience 2019 20:57- BMC Neuroscience 2019 20(Suppl 1):56This article is part of a Supplement: Volume 20 Supplement 1
Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease
Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptom...BMC Neuroscience 2019 20:55Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache
The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...BMC Neuroscience 2019 20:54Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males
Neuroactive steroids seem to be implicated in a variety of neurophysiological and behavioral processes, such as sleep, learning, memory, stress, feeding and aging. Numerous studies have also addressed this imp...BMC Neuroscience 2019 20:53Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxida...BMC Neuroscience 2019 20:52The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection
We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...BMC Neuroscience 2019 20:51Mouse corticospinal system comprises different functional neuronal ensembles depending on their hodology
Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structu...BMC Neuroscience 2019 20:50Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage
In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is th...BMC Neuroscience 2019 20:49Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current
Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...BMC Neuroscience 2019 20:48
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