Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

Molecular Underpinnings of Severe Coronavirus Disease 2019
RM Plenge, JAMA, July 24, 2020

Presence of Genetic Variants Among Young Men With Severe COVID-19
CI van der Made et al, JAMA, July 24, 2020

In 4 young male patients with severe COVID-19 from 2 families, rare loss-of-function variants of the X-chromosomal TLR7 were identified, with immunological defects in type I and II interferon production. These findings provide insights into the pathogenesis of COVID-19.

Estimated County-Level Prevalence of Selected Underlying Medical Conditions Associated with Increased Risk for Severe COVID-19 Illness - United States, 2018.
Razzaghi Hilda et al. MMWR. Morbidity and mortality weekly report 2020 Jul (29) 945-950

The median model-based estimate of the prevalence of any of five underlying medical conditions associated with increased risk for severe COVID-19–associated illness among U.S. adults was 47.2% among 3,142 U.S. counties. The estimated number of persons with these conditions followed population distributions, but prevalence was higher in more rural counties.

A country level analysis measuring the impact of government actions, country preparedness and socioeconomic factors on COVID-19 mortality and related health outcomes
R Chaudry et al, E Clinical Medicine, July 23, 2020

Mathematical models to guide pandemic response
CJE Metcalf et al, Science, July 23, 2020

Despite the devastating burden that COVID-19 has imposed so far, most of the world is still susceptible to SARS-CoV-2 infection. Models projecting into this future have evaluated policy scenarios and assessed the potential impact of seasonal variation in transmission.

The role of chest radiography in confirming covid-19 pneumonia.
Cleverley Joanne et al. BMJ (Clinical research ed.) 2020 07 m2426

A normal chest radiograph does not exclude covid-19 pneumonia. No single feature of covid-19 pneumonia on a chest radiograph is specific or diagnostic, but a combination of multifocal peripheral lung changes of ground glass opacity and/or consolidation, which are most commonly bilateral, may be present.