lunes, 6 de julio de 2020

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 ME Carter-Timoufle et al, Frontiers in Immunology, June 30, 2020

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Coronavirus

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
ME Carter-Timoufle et al, Frontiers in Immunology, June 30, 2020
While COVID-19 disease is most serious in patients with co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. We discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate athways that may be compromised in healthy individuals with fulminating COVID-19.
Is a “Cytokine Storm” Relevant to COVID-19?
P Sinha et al, JAMA Internal Medicine, June 30, 2020
the term cytokine storm may be misleading in COVID-19 ARDS. Incorporating a poorly defined pathophysiological entity lacking a firm biological diagnosis may only further increase uncertainty about how best to manage this heterogeneous population of patients.
Applications of digital technology in COVID-19 pandemic planning and response
S Whitelaw et al, Lancet Digital Health, June 29, 2020
This Viewpoint provides a framework for the application of digital technologies in pandemic management and response, highlighting ways in which successful countries have adopted these technologies for pandemic planning, surveillance, testing, contact tracing, quarantine, and health care.

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