Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 ME Carter-Timoufle et al, Frontiers in Immunology, June 30, 2020

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 Coronavirus

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
ME Carter-Timoufle et al, Frontiers in Immunology, June 30, 2020

While COVID-19 disease is most serious in patients with co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. We discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate athways that may be compromised in healthy individuals with fulminating COVID-19.

Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples
M Xiao et al Genome Medicine, June 30, 2020

End-to-End AI-Based Point-of-Care Diagnosis System for Classifying Respiratory Illnesses and Early Detection of COVID-19
AN Belkacem et al, ARXIV, June 28, 2020

Is a “Cytokine Storm” Relevant to COVID-19?
P Sinha et al, JAMA Internal Medicine, June 30, 2020

the term cytokine storm may be misleading in COVID-19 ARDS. Incorporating a poorly defined pathophysiological entity lacking a firm biological diagnosis may only further increase uncertainty about how best to manage this heterogeneous population of patients.

Applications of digital technology in COVID-19 pandemic planning and response
S Whitelaw et al, Lancet Digital Health, June 29, 2020

This Viewpoint provides a framework for the application of digital technologies in pandemic management and response, highlighting ways in which successful countries have adopted these technologies for pandemic planning, surveillance, testing, contact tracing, quarantine, and health care.

AIDCOV: An Interpretable Artificial Intelligence Model for Detection of COVID-19 from Chest Radiography Images
MZ et al, MEDRXIV, June 29, 2020

Assessment of the use and quick preparation of saliva for rapid microbiological diagnosis of COVID-19.
J Vila et al, BIORXIV, June 29, 2020