martes, 14 de julio de 2020

Journal of Experimental & Clinical Cancer Research | Articles

Journal of Experimental & Clinical Cancer Research | Articles

  • Owned by the Association for International Promotion & Study in Tumors (APSIT)
  • Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy
  1. Tumor progression and tumor response to anticancer therapies may be affected by activation of oncogenic pathways such as the antioxidant one induced by NRF2 (nuclear factor erythroid 2-related factor 2) transc...
    Authors:Alessia Garufi, Silvia Baldari, Riccardo Pettinari, Maria Saveria Gilardini Montani, Valerio D’Orazi, Giuseppa Pistritto, Alessandra Crispini, Eugenia Giorno, Gabriele Toietta, Fabio Marchetti, Mara Cirone and Gabriella D’Orazi
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:122
    Content type:Research
     
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  2. Angiogenesis plays an important role in the progress of glioma. RNA-binding proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been verified to mediate diverse biological behavi...
    Authors:Xiaobai Liu, Shuyuan Shen, Lu Zhu, Rui Su, Jian Zheng, Xuelei Ruan, Lianqi Shao, Di Wang, Chunqing Yang and Yunhui Liu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:121
    Content type:Research
     
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  3. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Giovanni Solimando, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:120
    Content type:Correction
     
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:95
  4. Gastric cancer (GC) is a common form of malignant cancer in worldwide which has a poor prognosis. Despite recent improvements in the treatment of GC, the prognosis is not yet satisfactory for GC patients. CYT997,...
    Authors:Ya Cao, Jinglong Wang, Hua Tian and Guo-Hui Fu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:119
    Content type:Research
     
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  5. Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and drug resistance. Tumor angiogenesis plays an ...
    Authors:Jun-Jie Chen, Yan-Lin Ren, Chuan-Jun Shu, Yi Zhang, Min-Juan Chen, Jin Xu, Jin Li, Ai-Ping Li, Dong-Yin Chen, Jing-Dong He, Yong-Qian Shu and Jian-Wei Zhou
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:118
    Content type:Research
     
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  6. The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic interventio...
    Authors:Katia Grillone, Caterina Riillo, Francesca Scionti, Roberta Rocca, Giuseppe Tradigo, Pietro Hiram Guzzi, Stefano Alcaro, Maria Teresa Di Martino, Pierosandro Tagliaferri and Pierfrancesco Tassone
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:117
    Content type:Review
     
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  7. Aberrant alternative splicing events play critical roles in carcinogenesis and progression of many cancers, while sparse studies regarding to alternative splicing are available for clear cell renal cell carcin...
    Authors:Guoliang Sun, Hui Zhou, Ke Chen, Jin Zeng, Yangjun Zhang, Libin Yan, Weimin Yao, Junhui Hu, Tao Wang, Jinchun Xing, Kefeng Xiao, Lily Wu, Zhangqun Ye and Hua Xu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:116
    Content type:Research
     
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  8. An amendment to this paper has been published and can be accessed via the original article.
    Authors:Jing Zhang, Xiao-han Liu, Cong Li, Xiao-xing Wu, Yan-lin Chen, Wen-wen Li, Xian Li, Fan Gong, Qin Tang and Dan Jiang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:115
    Content type:Correction
     
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    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:79
  9. Circular RNAs (circRNAs) play a critical regulatory role in cancer progression. However, the underlying mechanisms of circRNAs in hepatocellular carcinoma (HCC) metastasis remain mostly unknown.
    Authors:Li-na Song, Guang-lei Qiao, Jian Yu, Chun-mei Yang, Ying Chen, Zhou-feng Deng, Li-hua Song, Li-jun Ma and Hong-li Yan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:114
    Content type:Research
     
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  10. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive tumors in the world. Aryl hydrocarbon receptor (AHR) has been reported to promote tumor metastasis and epithelial-mesenchymal transition ...
    Authors:Peiyao Zhu, Huayun Yu, Kun Zhou, Yu Bai, Ruiqun Qi and Shuguang Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:113
    Content type:Research
     
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  11. Colorectal cancer is one of most common tumors in developed countries and, despite improvements in treatment and diagnosis, mortality rate of patients remains high, evidencing the urgent need of novel biomarke...
    Authors:Roberto Dinami, Manuela Porru, Carla Azzurra Amoreo, Isabella Sperduti, Marcella Mottolese, Simonetta Buglioni, Daniele Marinelli, Marcello Maugeri-Saccà, Andrea Sacconi, Giovanni Blandino, Carlo Leonetti, Giuliana Di Rocco, Alessandra Verdina, Francesca Spinella, Francesco Fiorentino, Gennaro Ciliberto…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:111
    Content type:Research
     
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  12. Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences ...
    Authors:Antonietta Rosella Farina, Lucia Cappabianca, Michela Sebastiano, Veronica Zelli, Stefano Guadagni and Andrew Reay Mackay
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:110
    Content type:Review
     
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  13. If we focus our attention on seven main features of COVID-19 infection (heterogeneity, fragility, lack of effective treatments and vaccines, “miraculous cures”, psychological suffering, deprivation, and globaliza...
    Authors:Nicola Silvestris, Giovanni Apolone, Gerardo Botti, Gennaro Ciliberto, Massimo Costantini, Paolo De Paoli, Silvia Franceschi, Giuseppe Opocher, Angelo Paradiso, Paolo Pronzato, Alessandro Sgambato and Ruggero De Maria
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:109
    Content type:Commentary
     
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  14. Chemo-resistance of bladder cancer has been considered to be one of the serious issues to be solved. In this study, we revealed pivotal role of miR-424 in the regulation of CDDP sensitivity of bladder cancer c...
    Authors:Meng Yu, Toshinori Ozaki, Dan Sun, Haotian Xing, Baojun Wei, Jun An, Jieping Yang, Ying Gao, Shuangjie Liu, Chuize Kong and Yuyan Zhu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:108
    Content type:Research
     
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  15. Fermented wheat germ extract has been reported to exert various pharmacological activities, including anti-oxidant, anti-cell growth and cell apoptosis in various cancer cells. Although 2,6-dimethoxy-1,4-benzo...
    Authors:Xueyin Zu, Xiaoli Ma, Xiaomeng Xie, Bingbing Lu, Kyle Laster, Kangdong Liu, Zigang Dong and Dong Joon Kim
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:107
    Content type:Research
     
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  16. Acylphosphatase 2 (ACYP2) is involved in cell differentiation, energy metabolism and hydrolysis of intracellular ion pump. It has been reported as a negative regulator in leukemia and a positive regulator in c...
    Authors:Mengdan Li, Banjun Ruan, Jing Wei, Qi Yang, Mingwei Chen, Meiju Ji and Peng Hou
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:106
    Content type:Research
     
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  17. DCZ3301, a novel aryl-guanidino compound previously reported by our group, exerts cytotoxic effects against multiple myeloma (MM), diffused large B cell lymphoma (DLBCL), and T-cell leukemia/lymphoma. However,...
    Authors:Liangning Hu, Bo Li, Gege Chen, Dongliang Song, Zhijian Xu, Lu Gao, Mengyu Xi, Jinfeng Zhou, Liping Li, Hui Zhang, Qilin Feng, Yingcong Wang, Kang Lu, Yumeng Lu, Wenxuan Bu, Houcai Wang…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:105
    Content type:Research
     
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  18. Although ongoing development of therapeutic strategies contributes to the improvements in clinical management, clear cell renal cell carcinoma (ccRCC) deaths originate mainly from radiochemoresistant and metas...
    Authors:Jinbo Sun, Qisheng Tang, Yongheng Gao, Wei Zhang, Zhining Zhao, Fan Yang, Xiangnan Hu, Dan Zhang, Yong Wang, Huizhong Zhang, Bin Song, Bo Zhang and He Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:104
    Content type:Research
     
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  19. Understanding the signalling pathways involved in angiogenesis, and developing anti-angiogenic drugs are one of the major focuses on cancer research. Herein, we assessed the effect of CPTH6, a lysine acetyltra...
    Authors:Marta Di Martile, Chiara Gabellini, Marianna Desideri, Marta Matraxia, Valentina Farini, Elisabetta Valentini, Simone Carradori, Cristiana Ercolani, Simonetta Buglioni, Daniela Secci, Massimiliano Andreazzoli, Donatella Del Bufalo and Daniela Trisciuoglio
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:103
    Content type:Research
     
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  20. Human papillomavirus (HPV)-positive oral squamous cell carcinoma (OSCC) is increasing worldwide with typically higher grade and stage, while better prognosis. microRNAs (miRNAs) has been shown to play a critic...
    Authors:Ming-xin Cao, Wei-long Zhang, Xiang-hua Yu, Jia-shun Wu, Xin-wei Qiao, Mei-chang Huang, Ke Wang, Jing-biao Wu, Ya-Jie Tang, Jian Jiang, Xin-hua Liang and Ya-ling Tang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:102
    Content type:Research
     
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  21. Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB.
    Authors:Yanfeng Liu, Jianping Song, Yu Liu, Zhipeng Zhou and Xianqiang Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:101
    Content type:Research
     
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  22. Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the m...
    Authors:Kenly Wuputra, Chia-Chen Ku, Deng-Chyang Wu, Ying-Chu Lin, Shigeo Saito and Kazunari K. Yokoyama
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:100
    Content type:Review
     
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  23. Therapeutic options for patients with hepatocellular carcinoma (HCC) are limited. Transarterial chemoembolization (TACE) is an interventional procedure used to deliver chemotherapy and embolizing agents direct...
    Authors:Sean P. Martin, Valerie Fako, Hien Dang, Dana A. Dominguez, Subreen Khatib, Lichun Ma, Haiyang Wang, Wei Zheng and Xin Wei Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:99
    Content type:Research
     
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  24. The rising incidence of renal cell carcinomas (RCC) constitutes a significant challenge owing to risk of overtreatment. Because aberrant microRNA (miR) promoter methylation contributes to cancer development, w...
    Authors:Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique and Carmen Jerónimo
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:98
    Content type:Research
     
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  25. Hepatocellular carcinoma (HCC) is one of the most common malignancies today. Patients suffer from HCC since its high malignancy and limited treatment means. With the development of genetic research, new therap...
    Authors:Xiaoling Wu, Weijie Ma, Chengjie Mei, Xi Chen, Ye Yao, Yingyi Liu, Xian Qin and Yufeng Yuan
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:97
    Content type:Review
     
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  26. Long intergenic non-protein coding RNA 520 (LINC00520), a novel identified lncRNA, has been shown to modulate the malignant phenotype of tumor cells in some malignant tumors. However, the exact role and molecu...
    Authors:Wenkang Luan, Yuting Ding, Haitao Yuan, Shaojun Ma, Hongru Ruan, Jinlong Wang, Feng Lu and Xuefeng Bu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:96
    Content type:Research
     
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  27. In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly presen...
    Authors:Marco Russano, Andrea Napolitano, Giulia Ribelli, Michele Iuliani, Sonia Simonetti, Fabrizio Citarella, Francesco Pantano, Emanuela Dell’Aquila, Cecilia Anesi, Nicola Silvestris, Antonella Argentiero, Antonio Giovanni Solimando, Bruno Vincenzi, Giuseppe Tonini and Daniele Santini
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:95
    Content type:Review
     
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  28. Circular RNAs (circRNAs) have been associated with bladder cancer (BC), but the specific underlying molecular mechanism of their association with BC development has not been fully explored.
    Authors:Liang Chen, Xiong Yang, Jun Zhao, Ming Xiong, Raya Almaraihah, Zhaohui Chen and Teng Hou
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:94
    Content type:Research
     
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  29. Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose-dependent cardiotoxicity. Dihydrotanshinone...
    Authors:Xiaoping Wang, Qiyan Wang, Weili Li, Qian Zhang, Yanyan Jiang, Dongqing Guo, Xiaoqian Sun, Wenji Lu, Chun Li and Yong Wang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:93
    Content type:Research
     
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  30. The RNA-binding protein Musashi-2 (MSI2) has been implicated in the tumorigenesis and tumor progression of some human cancers. MSI2 has also been reported to suppress tumor epithelial-to-mesenchymal transition...
    Authors:Ming Li, An-qi Li, Shu-ling Zhou, Hong Lv, Ping Wei and Wen-tao Yang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:92
    Content type:Research
     
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  31. Colorectal cancer (CRC) is one of the most common malignant tumors globally. Angiogenesis is a key event maintaining tumor cell survival and aggressiveness. The expression of vascular endothelial growth factor...
    Authors:Chen Chen, Zhiguo Huang, Xiaoye Mo, Yanmin Song, Xiangmin Li, Xiaogang Li and Mu Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:91
    Content type:Research
     
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  32. ATP binding cassette subfamily A member 8 (ABCA8) belongs to the ATP binding cassette (ABC) transporter superfamily. ABCA8 is a transmembrane transporter responsible for the transport of organics, such as chol...
    Authors:Yifeng Cui, Shuhang Liang, Shugeng Zhang, Congyi Zhang, Yunzheng Zhao, Dehai Wu, Jiabei Wang, Ruipeng Song, Jizhou Wang, Dalong Yin, Yao Liu, Shangha Pan, Xirui Liu, Yan Wang, Jihua Han, Fanzheng Meng…
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:90
    Content type:Research
     
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  33. Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...
    Authors:Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nisticò and Alberto Signore
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:89
    Content type:Review
     
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  34. Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventi...
    Authors:Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu and Wei Li
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:88
    Content type:Research
     
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  35. Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown ...
    Authors:Yuexian Zhou, Huifang Zong, Lei Han, Yueqing Xie, Hua Jiang, John Gilly, Baohong Zhang, Huili Lu, Jie Chen, Rui Sun, Zhidi Pan and Jianwei Zhu
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:87
    Content type:Research
     
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  36. The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri...
    Authors:Gennaro Ciliberto, Rita Mancini and Marco G. Paggi
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:86
    Content type:Review
     
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  37. Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely ...
    Authors:Kai Liu, Minying Zheng, Qi Zhao, Kexin Zhang, Zugui Li, Fangmei Fu, Hao Zhang, Jiaxing Du, Yuwei Li and Shiwu Zhang
    Citation:Journal of Experimental & Clinical Cancer Research 2020 39:83
    Content type:Research
     
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