Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation
Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic e...The Journal of Physiological Sciences 2020 70:32Combined high-intensity interval training and green tea supplementation enhance metabolic and antioxidant status in response to acute exercise in overweight women
Thirty sedentary overweight women were randomly assigned to three groups (n = 10), including HIIT + green tea, HIIT + placebo and green tea. The training program included 3 sessions/week HIIT while the supplement...The Journal of Physiological Sciences 2020 70:31Effects of nicotine on regional blood flow in the olfactory bulb in response to olfactory nerve stimulation
This study examined the effect of olfactory nerve stimulation on regional cerebral blood flow and assessed the effect of intravenous nicotine administration on this response in anesthetized rats. Regional cere...The Journal of Physiological Sciences 2020 70:30Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer’s disease models
Tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 (SP1)-mediated cyclin-dependent kinase-5 (CDK5), a major pr...The Journal of Physiological Sciences 2020 70:29The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy
The efficacy of insulin-like growth factor 1 (IGF-1) in the treatment of peripheral facial nerve palsy was investigated using an animal model. The facial nerve within the temporal bone was exposed and compress...The Journal of Physiological Sciences 2020 70:28- The Journal of Physiological Sciences 2020 70:27
Neuropsin in mental health
Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. Its substrates comprise several molecule...The Journal of Physiological Sciences 2020 70:26An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses
We investigated that the effects of hypercapnia-induced elevations in cerebral perfusion during a heat stress on global cerebrovascular responses to an orthostatic challenge. Seven volunteers completed a progr...The Journal of Physiological Sciences 2020 70:25Membrane current evoked by mitochondrial Na+–Ca2+ exchange in mouse heart
The electrogenicity of mitochondrial Na+–Ca2+ exchange (NCXm) had been controversial and no membrane current through it had been reported. We succeeded for the first time in recording NCXm-mediated currents using...The Journal of Physiological Sciences 2020 70:24Effect of sinusoidal leg cycling exercise period on brachial artery blood flow dynamics in humans
To quantify the dynamics of blood flow in brachial artery (BF-BA) in response to sinusoidal work rate (WR) leg cycling exercises of 2-, 4-, and 6-min periods and to examine their relationship with the forearm ...The Journal of Physiological Sciences 2020 70:23Effect of the parasympathetic vasodilation on temperature regulation via trigeminal afferents in the orofacial area
The skin temperature (Tm) of the orofacial area influences orofacial functions and is related to the blood flow (BF). Marked increases in BF mediated by parasympathetic vasodilation may be important for orofacial...The Journal of Physiological Sciences 2020 70:22Effect of coronary artery bypass grafting on blood pressure response to head-up tilting
Blood pressure response to head-up tilt (HUT) in 7 healthy subjects and 9 patients before and after coronary artery bypass grafting (CABG) was measured during supine and 15-min 60° HUT. Stroke volume (SV) and ...The Journal of Physiological Sciences 2020 70:21Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes
The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated the effect of Csx/Nkx2.5 on the expression of cardiac ion c...The Journal of Physiological Sciences 2020 70:20Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats
High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders...The Journal of Physiological Sciences 2020 70:19Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice
Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation and autophagy. However, the role of PI3K-C2α and PI3K-C2β at the...The Journal of Physiological Sciences 2020 70:18Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment
The peripheral vestibular organs are sensors for linear acceleration (gravity and head tilt) and rotation. Further, they regulate various body functions, including body stability, ocular movement, autonomic ne...The Journal of Physiological Sciences 2020 70:17Respiratory pattern and phrenic and hypoglossal nerve activity during normoxia and hypoxia in 6-OHDA-induced bilateral model of Parkinson’s disease
Respiratory disturbances present in Parkinson’s disease (PD) are not well understood. Thus, studies in animal models aimed to link brain dopamine (DA) deficits with respiratory impairment are needed. Adult Wis...The Journal of Physiological Sciences 2020 70:16Males benefit more from cold water immersion during repeated handgrip contractions than females despite similar oxygen kinetics
The purpose of the present study was to assess the effect of different water immersion temperatures on handgrip performance and haemodynamic changes in the forearm flexors of males and females. Twenty-nine roc...The Journal of Physiological Sciences 2020 70:13Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model
Experiments on animal hearts (rat, rabbit, guinea pig, etc.) have demonstrated that mechano-calcium feedback (MCF) and mechano-electric feedback (MEF) are very important for myocardial self-regulation because ...The Journal of Physiological Sciences 2020 70:12Pathophysiological properties of CLIC3 chloride channel in human gastric cancer cells
Pathophysiological functions of chloride intracellular channel protein 3 (CLIC3) in human gastric cancer have been unclear. In the tissue microarray analysis using 107 gastric cancer specimens, CLIC3 expressio...The Journal of Physiological Sciences 2020 70:15Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats
Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective effects of donepezil, how...The Journal of Physiological Sciences 2020 70:11Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury
Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart t...The Journal of Physiological Sciences 2020 70:10Comparative study of hyperpolarization-activated currents in pulmonary vein cardiomyocytes isolated from rat, guinea pig, and rabbit
Pulmonary vein (PV) cardiomyocytes have the potential to generate spontaneous activity, in contrast to working myocytes of atria. Different electrophysiological properties underlie the potential automaticity o...The Journal of Physiological Sciences 2020 70:6Paired mechanical and electrical acupuncture of neurogenic spots induces opioid-mediated suppression of hypertension in rats
While our recent studies have suggested that effective acupoints display neurogenic inflammation and can be identified as neurogenic spots (Neuro-Sps), the optimal stimulation conditions and the underlying mec...The Journal of Physiological Sciences 2020 70:14Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1
We have previously reported that the negative inotropic effects of hyperthermia (42 °C) on left ventricular (LV) mechanoenergetics using the excised, cross-circulated rat heart model. Here, we investigated the...The Journal of Physiological Sciences 2020 70:4Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations
The present study aimed to investigate whether endurance exercise-induced changes in blood plasma composition may lead to adaptations in erythrocytes, skeletal muscle and liver. Forty sedentary rats were rando...The Journal of Physiological Sciences 2020 70:3Increase in diastolic blood pressure induced by fragrance inhalation of grapefruit essential oil is positively correlated with muscle sympathetic nerve activity
Fragrance inhalation of essential oils is widely used in aromatherapy, and it is known to affect blood pressure (BP) and heart rate (HR) via autonomic control of circulation. In this study, we aimed to test th...The Journal of Physiological Sciences 2020 70:2Dynamic cerebral autoregulation in anterior and posterior cerebral circulation during cold pressor test
We hypothesized that cerebral blood flow (CBF) regulation in the posterior circulation differs from that of the anterior circulation during a cold pressor test (CPT) and is accompanied by elevations in arteria...The Journal of Physiological Sciences 2020 70:1Potential role of hypothalamic microRNAs in regulation of FOS and FTO expression in response to hypoglycemia
Hypoglycemia-associated autonomic failure (HAAF) is a serious complication of diabetes which is associated with the absence of physiological homeostatic counter-regulatory mechanisms that are controlled by the...The Journal of Physiological Sciences 2019 69:718Sex differences in baroreflex function in health and disease
This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been demonstrated that healthy women have blunted cardiovagal baror...The Journal of Physiological Sciences 2019 69:727Acupoint dependence of depressor and bradycardic responses elicited by manual acupuncture stimulation in humans
The cardiovascular effects of the autonomic nervous system (ANS) are modulated by inputs from peripheral sensors and other brain regions. However, it currently remains unknown whether the manual acupuncture (M...The Journal of Physiological Sciences 2019 69:728The effect of 5-HT1A receptor antagonist on reward-based decision-making
When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin...The Journal of Physiological Sciences 2019 69:725Mild foot electrical stimulation is comparable with phenytoin in inhibiting pentylenetetrazol-induced kindling in rats
Increasing evidence demonstrates that electric stimulation has anticonvulsant effects. The present study was undertaken to investigate the effects of mild foot electrical stimulation (MFES) on the development ...The Journal of Physiological Sciences 2019 69:726Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice
We aimed to identify the neurotransmitters and brain regions involved in exercise efficiency in mice during continuous complicated exercises. Male C57BL/6J mice practiced treadmill running with intermittent ob...The Journal of Physiological Sciences 2019 69:722- The Journal of Physiological Sciences 2019 69:717
Firing properties of medullary expiratory neurons during fictive straining in cats
Expiratory (E) neurons in the caudal nucleus retroambigualis extend descending spinal axons to the lumbar and sacral spinal cord. Discharge rates of single E neurons were recorded to examine differences in act...The Journal of Physiological Sciences 2019 69:715Tonic contraction develops in the colon during anaphylactic hypotension in anesthetized rats
Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressu...The Journal of Physiological Sciences 2019 69:710TRPM8-mediated cutaneous stimulation modulates motor neuron activity during treadmill stepping in mice
Motor units are generally recruited from the smallest to the largest following the size principle, while cutaneous stimulation has the potential to affect spinal motor control. We aimed to examine the effects ...The Journal of Physiological Sciences 2019 69:707Queueing arrival and release mechanism for K+ permeation through a potassium channel
The mechanism underlying ion permeation through potassium channels still remains controversial. K+ ions permeate across a narrow selectivity filter (SF) in a single file. Conventional scenarios assume that K+ ion...The Journal of Physiological Sciences 2019 69:706Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice
This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) wer...The Journal of Physiological Sciences 2019 69:703Effect of regional muscle damage and inflammation following eccentric exercise on electrical resistance and the body composition assessment using bioimpedance spectroscopy
We investigated the effect of muscle damage and inflammation on electrical resistance and the body composition assessment by using bioimpedance spectroscopy (BIS). Twenty-two subjects completed 30 repetitions ...The Journal of Physiological Sciences 2019 69:702- The Journal of Physiological Sciences 2019 69:699
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Augmented fear bradycardia in rats with heart failure
In congestive heart failure (CHF), while resting parasympathetic activity becomes reduced, parasympathetically-mediated responses to stressors have not been described. This study aimed to (1) elucidate the eff...The Journal of Physiological Sciences 2019 69:698Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism
Near-infrared spectroscopy (NIRS) has become an increasingly valuable tool to monitor tissue oxygenation (Toxy) in vivo. Observations of changes in the absorption of light with Toxy have been recognized as early ...The Journal of Physiological Sciences 2019 69:697
sábado, 18 de julio de 2020
The Journal of Physiological Sciences | Articles
The Journal of Physiological Sciences | Articles
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