Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome - PubMed

Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome - PubMed

Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome

Swetlana Ladigan-Badura # 1, Deepak B Vangala # 1, Christoph Engel 2, Karolin Bucksch 2, Robert Hueneburg 3 4, Claudia Perne 4 5, Jacob Nattermann 3, Verena Steinke-Lange 6 7, Nils Rahner 8, Hans K Schackert 9, Jürgen Weitz 9, Matthias Kloor 10, Judith Kuhlkamp 1, Huu Phuc Nguyen 11, Gabriela Moeslein 12, Christian Strassburg 3 4, Monika Morak 6 7, Elke Holinski-Feder 6 7, Reinhard Buettner 13, Stefan Aretz 4 5, Markus Loeffler 2, Wolff Schmiegel 1, Christian Pox 14, Karsten Schulmann 15 16, German Consortium for Familial Intestinal Cancer

Affiliations 

• PMID: 32930401
 
• DOI: 10.1002/ijc.33294

Abstract

In this study we evaluated the effectiveness of upper GI endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analysing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicentre cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1-3 years. Forty-nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = 0.0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. This study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.

Keywords: HNPCC; Lynch syndrome; gastric cancer; screening; surveillance.

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