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Hereditas

The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis

The Notch signaling pathway is highly conserved in eukaryotes. Notch repressors, however, are only known from arthropods and vertebrates (Drosophila: Hairless, vertebrates: SHARP/MINT and KyoT2). Database searches revealed homologues of Hairless only after the Chelicerata-Mandibulata radiation, SHARP only in vertebrates, and KyoT2 with a ΦWΦP interacting motif only in placental mammals. However, the data provide a hypothesis on the evolution of KyoT2 from Prickle-like ancestors. These Prickle-like ancestors contain a novel, putative CSL interacting motif. If it were confirmed by experiments, this work has uncovered a novel, very ancestral CSL interactor found in the entire animal kingdom.

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• The Mendelian Society of Lundhas been publishing the journal Hereditas since 1920. 

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1. Content Type:Research

     |  6 February 2019

   Characterization of the Tibet plateau Jerusalem artichoke (Helianthus tuberosus L.) transcriptome by de novo assembly to discover genes associated with fructan synthesis and SSR analysis

   Authors:Shipeng Yang, Xuemei Sun, Xiaoting Jiang, Lihui Wang, Jie Tian, Li Li, Mengliang Zhao and Qiwen Zhong
2. Content Type:Research

     |  6 February 2019

   Global transcriptome analysis of H5N1 influenza virus-infected human cells

   Authors:Ying Cao, Kun Zhang, Lirong Liu, Wei Li, Bin Zhu, Shuang Zhang, Ping Xu, Wenjun Liu and Jing Li
3. Content Type:Research

     |  29 January 2019

   Genetic diversity and structure of Elymus tangutorumaccessions from western China as unraveled by AFLP markers

   Authors:Wen-Dan Wu, Wen-Hui Liu, Ming Sun, Ji-Qiong Zhou, Wei Liu, Cheng-Lin Zhang, Xing-Quan Zhang, Yan Peng, Lin-Kai Huang and Xiao Ma
4. Content Type:Research

     |  28 January 2019

   Bladder cancer stage-associated hub genes revealed by WGCNA co-expression network analysis

   Authors:Yu Di, Dongshan Chen, Wei Yu and Lei Yan
5. Content Type:Research

     |  26 January 2019

   A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level

   Authors:Yu Wu, Miaomiao Wang, Jinlong Zhang, Na Sun and Chunping Li