Editors' Pick: Limited physical space in the human bone marrow
The attractive concept of limited "immunological space” whereby senescent and exhausted cells crowd out functional cells in older individuals has proven difficult to substantiate in humans where most studies are limited to peripheral blood. Naismith et al. now demonstrate that this “crowding effect” is observed in the rarely-studied human bone marrow environment and potentially results in lower titers of pathogen-specific antibodies in the blood, implying an important clinical relevance of this phenomenon
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