Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow | Immunity & Ageing | Full Text

Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow | Immunity & Ageing | Full Text

Editors' Pick: Limited physical space in the human bone marrow

The attractive concept of limited "immunological space” whereby senescent and exhausted cells crowd out functional cells in older individuals has proven difficult to substantiate in humans where most studies are limited to peripheral blood. Naismith et al. now demonstrate that this “crowding effect” is observed in the rarely-studied human bone marrow environment and potentially results in lower titers of pathogen-specific antibodies in the blood, implying an important clinical relevance of this phenomenon