Corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease with an unknown etiology. Disturbed corticospinal inhibition of the motor cortex has been reported in iNPH and can be evaluated in...Fluids and Barriers of the CNS 2020 17:6Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance
Cerebrospinal fluid (CSF) is mainly produced by the choroid plexus (CP) located in brain ventricles. Although derived from blood plasma, it is nearly protein-free (~ 250-fold less) and contains about 2–20-fold...Fluids and Barriers of the CNS 2020 17:17Quantitatively relating brain endothelial cell–cell junction phenotype to global and local barrier properties under varied culture conditions via the Junction Analyzer Program
The endothelial cell–cell junctions of the blood–brain barrier (BBB) play a pivotal role in the barrier’s function. Altered cell–cell junctions can lead to barrier dysfunction and have been implicated in sever...Fluids and Barriers of the CNS 2020 17:16Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system
The classical view of cerebrospinal fluid (CSF) production posits the choroid plexus as its major source. Although previous studies indicate that part of CSF production occurs in the subarachnoid space (SAS), ...Fluids and Barriers of the CNS 2020 17:15Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
Idiopathic intracranial hypertension (IIH) is a neurological disorder characterised by raised cerebrospinal fluid (CSF) pressure in the absence of any intracranial pathology. IIH mainly affects women with obes...Fluids and Barriers of the CNS 2020 17:10Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage
Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, b...Fluids and Barriers of the CNS 2020 17:5Increased age and male sex are independently associated with higher frequency of blood–cerebrospinal fluid barrier dysfunction using the albumin quotient
The cerebrospinal fluid (CSF)/serum quotient of albumin (QAlb) is the most used biomarker for the evaluation of blood–cerebrospinal fluid barrier (B-CSF-B) permeability. For years QAlb was considered only as a...Fluids and Barriers of the CNS 2020 17:14Hypercholesterolemia negatively influences morphology and molecular markers of epithelial cells within the choroid plexus in rabbits
Choroid plexus (CP) is an important tissue not only to produce cerebrospinal fluid (CSF) but also to regulate substances that are secreted into or absorbed from CSF through blood–cerebrospinal fluid barrier (B...Fluids and Barriers of the CNS 2020 17:13- Fluids and Barriers of the CNS 2020 17:12
Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
The brain barriers establish compartments in the central nervous system (CNS) that significantly differ in their communication with the peripheral immune system. In this function they strictly control T-cell e...Fluids and Barriers of the CNS 2020 17:3Longitudinal analysis of cerebral aqueduct flow measures: multiple sclerosis flow changes driven by brain atrophy
Several small cross-sectional studies have investigated cerebrospinal fluid (CSF) flow dynamics in multiple sclerosis (MS) patients and have reported mixed results. Currently, there are no longitudinal studies...Fluids and Barriers of the CNS 2020 17:9Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due t...Fluids and Barriers of the CNS 2020 17:4Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study
Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood ...Fluids and Barriers of the CNS 2020 17:1Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium
Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3− import into choroid plexus epithelial cells in mice and to a...Fluids and Barriers of the CNS 2020 17:2Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus
Communicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF...Fluids and Barriers of the CNS 2019 16:40The legacy of Malcolm Beverley Segal (1937–2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology
This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to th...Fluids and Barriers of the CNS 2019 16:41Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
A growing body of evidence suggests that the accumulation of amyloid-β and tau (HPτ) in the brain of patients with the dementia subtype idiopathic normal pressure hydrocephalus (iNPH) is associated with delaye...Fluids and Barriers of the CNS 2019 16:39Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease
Research into amisulpride use in Alzheimer’s disease (AD) implicates blood–brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB transporters has been mainly directed towards the ABC ...Fluids and Barriers of the CNS 2019 16:38Repeated lumbar punctures within 3 days may affect CSF biomarker levels
Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers fo...Fluids and Barriers of the CNS 2019 16:37- Fluids and Barriers of the CNS 2019 16(Suppl 3):36This article is part of a Supplement: Volume 16 Supplement 3
Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension
Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of...Fluids and Barriers of the CNS 2019 16:35Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins
Cerebrospinal fluid (CSF) metabolomic investigations are a powerful tool for studying neurometabolic diseases. We aimed to assess the effect of CSF contamination with blood on the concentrations of selected bi...Fluids and Barriers of the CNS 2019 16:34B waves: a systematic review of terminology, characteristics, and analysis methods
Although B waves were introduced as a concept in the analysis of intracranial pressure (ICP) recordings nearly 60 years ago, there is still a lack consensus on precise definitions, terminology, amplitude, freq...Fluids and Barriers of the CNS 2019 16:33Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields
Influx and clearance of substances in the brain parenchyma occur by a combination of diffusion and convection, but the relative importance of these mechanisms is unclear. Accurate modeling of tracer distributi...Fluids and Barriers of the CNS 2019 16:32Claudin-12 is not required for blood–brain barrier tight junction function
The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS. Complex and continuous tight junct...Fluids and Barriers of the CNS 2019 16:30- Fluids and Barriers of the CNS 2019 16(Suppl 2):29This article is part of a Supplement: Volume 16 Supplement 2
Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2).Fluids and Barriers of the CNS 2019 16:31The original article was published in Fluids and Barriers of the CNS 2019 16:25Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML), caused by infection with John Cunningham polyoma virus (JCPyV) in immune-compromised patients, is a serious demyelinating disease of the central nervous system...Fluids and Barriers of the CNS 2019 16:28Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
Human induced pluripotent stem cells (hiPSC) hold great promise for use in cell therapy applications and for improved in vitro models of human disease. So far, most hiPSC differentiation protocols to astroglia...Fluids and Barriers of the CNS 2019 16:27Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood–borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood–bra...Fluids and Barriers of the CNS 2019 16:26An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of t...Fluids and Barriers of the CNS 2019 16:25The Correction to this article has been published in Fluids and Barriers of the CNS 2019 16:31The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
The Kuopio University Hospital (KUH) idiopathic normal pressure hydrocephalus (iNPH) cerebrospinal fluid (CSF) shunting protocol is described together with the initial outcomes of 175 patients with probable iN...Fluids and Barriers of the CNS 2019 16:21The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model
Blood–brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to...Fluids and Barriers of the CNS 2019 16:20Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow? A commentary on “Analysis of convective and diffusive transport in the brain interstitium” Fluids and Barriers of the CNS (2019) 16:6 by L. Ray, J.J. Iliff and J.J. Heys
Solutes can enter and leave gray matter in the brain by perivascular routes. The glymphatic hypothesis supposes that these movements are a consequence of inward flow along periarterial spaces and an equal outw...Fluids and Barriers of the CNS 2019 16:24The original article was published in Fluids and Barriers of the CNS 2019 16:6The Letter to the Editor Response to this article has been published in Fluids and Barriers of the CNS 2019 16:23In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”
In our work, “Analysis of Convective and Diffusive Transport in the Brain Interstitium”, published in this journal (2019, 16:6), we estimate the interstitial superficial velocity by comparison of transport model ...Fluids and Barriers of the CNS 2019 16:23The original article was published in Fluids and Barriers of the CNS 2019 16:24Correction to: A26 Cerebrospinal fluid outflow resistance is increased following small-moderate ischaemic stroke
After publication of this supplement [1], it was brought to our attention that in the results the line “(0.3 ± 0.04 mmHg/μl/min, and 0.54 ± 0.04 mmHg/μl/min, respectively)” should actually read “(0.54 ± 0.04 m...Fluids and Barriers of the CNS 2019 16:22The original article was published in Fluids and Barriers of the CNS 2019 16:16Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential ...Fluids and Barriers of the CNS 2019 16:18Hydraulic resistance of periarterial spaces in the brain
Periarterial spaces (PASs) are annular channels that surround arteries in the brain and contain cerebrospinal fluid (CSF): a flow of CSF in these channels is thought to be an important part of the brain’s syst...Fluids and Barriers of the CNS 2019 16:19- Fluids and Barriers of the CNS 2019 16(Suppl 1):16This article is part of a Supplement: Volume 16 Supplement 1The Correction to this article has been published in Fluids and Barriers of the CNS 2019 16:22
A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct
Altered flow of cerebrospinal fluid (CSF) within the subarachnoid space (SAS) is connected to brain, but also optic nerve degenerative diseases. To overcome the lack of suitable in vitro models that faithfully...Fluids and Barriers of the CNS 2019 16:17Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
Pericytes of the blood–brain barrier (BBB) are embedded within basement membrane between brain microvascular endothelial cells (BMECs) and astrocyte end-feet. Despite the direct cell–cell contact observed in v...Fluids and Barriers of the CNS 2019 16:15The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
Brain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals...Fluids and Barriers of the CNS 2019 16:14The need for mathematical modelling of spatial drug distribution within the brain
The blood brain barrier (BBB) is the main barrier that separates the blood from the brain. Because of the BBB, the drug concentration-time profile in the brain may be substantially different from that in the b...Fluids and Barriers of the CNS 2019 16:12Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between...Fluids and Barriers of the CNS 2019 16:13Enhanced in vitro model of the CSF dynamics
Fluid dynamics of the craniospinal system are complex and still not completely understood. In vivo flow and pressure measurements of the cerebrospinal fluid (CSF) are limited. Whereas in silico modeling can be...Fluids and Barriers of the CNS 2019 16:11Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
The fine balance between the secretion, composition, volume and turnover of cerebrospinal fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance can be disrupted. A sign...Fluids and Barriers of the CNS 2019 16:9Spinal CSF flow in response to forced thoracic and abdominal respiration
Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present st...Fluids and Barriers of the CNS 2019 16:10The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid
The central nervous system was previously thought to draw oxygen and nutrition from the arteries and discharge carbon dioxide and other metabolic wastes into the venous system. At present, the functional role ...Fluids and Barriers of the CNS 2019 16:8Effect of extradural constriction on CSF flow in rat spinal cord
Fluid homeostasis in the central nervous system (CNS) is essential for normal neurological function. Cerebrospinal fluid (CSF) in the subarachnoid space and interstitial fluid circulation in the CNS parenchyma...Fluids and Barriers of the CNS 2019 16:7
martes, 25 de febrero de 2020
Fluids and Barriers of the CNS | Articles
Fluids and Barriers of the CNS | Articles
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