Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

The Coronavirus Is Mutating, and That’s Fine (So Far) SARS-CoV-2 has been slowly changing in small ways, without getting more dangerous.
E Holmes, NY Times, September 11, 2020

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource
S Portelli et al, Nature Genetics, September 10, 2020

Despite the novelty of the virus, global sequencing efforts have already identified genomic variation across isolates. To enable easy exploration and spatial visualization of the potential implications of SARS-CoV-2 mutations in infection, host immunity and drug development, we have developed COVID-3D.

The UCSC SARS-CoV-2 Genome Browser
JD Fernandes et al, Nature Genetics, September 10, 2020

The browser is an adaptation of our popular genome-browser visualization tool for this virus, containing many annotation tracks and new features, including conservation with similar viruses, immune epitopes, RT–PCR and sequencing primers and CRISPR guides.

Exploring the coronavirus pandemic with the WashU Virus Genome Browser
Nature Genetics, September 9, 2020

This is a web-based portal for efficient visualization of viral ‘omics’ data in the context of a variety of annotation tracks and host infection responses. The browser features both a phylogenetic-tree-based view and a genomic-coordinate, track-based view in which users can analyze the sequence features of viral genomes, sequence diversity among viral strains, genomic sites of diagnostic tests, predicted immunogenic epitopes and a continuously updated repository of publicly available genomic datasets.

Why obesity worsens COVID-19
M Wadman, Science, September 11, 2020

Since the pandemic began, dozens of studies have reported that many of the sickest COVID-19 patients have been people with obesity. In recent weeks, that link has come into sharper focus as large new population studies have cemented the association and demonstrated that even people who are merely overweight are at higher risk.

Analysis of SARS-CoV-2 genomes from across Africa reveals potentially clinically relevant mutations
BC Iweriebor et al, BIORXIV, September 8, 220

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
AA Minervina et al, BIORXIV, September 8, 2020

Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression
AF Rendeiro et al, MEDRIV, September 9, 2020

Clinical Outcomes of Critically Ill Patients with COVID-19 by Race
F Marmarchi et al,MEDRXIV, September 9, 2020