Coronavirus [NEW TOPIC PAGE]

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 Coronavirus

The association between ABO blood group and SARS-CoV-2 infection: a meta-analysis
D Golinelli et al, MEDRXIV, September 3, 2020

The results of our meta-analysis indicate that SARS-CoV-2 positive individuals are more likely to have blood group A (pooled OR 1.23, 95%CI: 1.09-1.40) and less likely to have blood group O (pooled OR=0.77, 95%CI: 0.67-0.88).

Social Determinants Associated with COVID-19 Mortality in the United States
S Depopaphaya et al, MEDRXIV, September 3, 2020

Racial/Ethnic Disparities in Hospital Admissions from COVID-19 and Determining the Impact of Neighborhood Deprivation and Primary Language.
NE Ingraham et al, MEDRXIV, September 3, 2020

Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification
H Vasudevan et al, MEDRXIV, September 3, 2020

Unique mutational changes in SARS-CoV-2 genome: A case study for the largest state of India
P Prasad et al, BIORXIV, September 2, 2020

Real-time Prediction of COVID-19 related Mortality using Electronic Health Records
P Schwab et al, ARXIV, August 31, 2020

COVID-19 and mRNA Vaccines—First Large Test for a New Approach
J Abbasi, JAMA, September 3, 2020

Gene-based vaccines carry instructions for the host’s cells to make the antigen, which more closely mimics a natural infection. The antigen is the surface spike protein the virus uses to bind and fuse with human cells. “You’re not giving them the protein—you’re giving them the genetic material that then instructs them how to make that spike protein."

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions.
Kox Matthijs et al. JAMA 2020 Sep

There were 46 patients with COVID-19 with ARDS, 51 with septic shock with ARDS, 15 with septic shock without ARDS, 30 with OHCA, and 62 with multiple traumas. Preliminary analysis suggest COVID-19 may not be characterized by cytokine storm. Whether anticytokine therapies will benefit patients with COVID-19 remains to be determined.