Coronavirus [NEW TOPIC PAGE]

Hot Topics of the Day|PHGKB

 Coronavirus

Regardless of Age, Obesity and Hypertension Increase Risks With COVID-19
MH Katz, JAMA Internal Medicine, September 9, 2020

Obesity and Hypertension in the Time of COVID-19
G Rodgers et al, JAMA September 9, 2020

The confluence of disturbing trends in obesity, hypertension, and COVID-19 within communities of color appears to reflect a complex interplay of contributing factors that are rooted in the social determinants of health and structural racism.

Frequency and accuracy of proactive testing for COVID-19
T Bergstrom et al, MedRXIV, September 8, 2020

Genomic analysis reveals local transmission of SARS-CoV-2 in early pandemic phase in Peru
CP Rojas et al, BIORXIV, September 7, 2020

Mutational Analysis of SARS-CoV-2 Genome in African Population
OE Omotoso et al, BIORXIV, September 7, 2020

MOLECULAR EPIDEMIOLOGY TO UNDERSTAND THE SARS-CoV-2 EMERGENCE IN THE BRAZILIAN AMAZON REGION
MC De Santos et al, MEDRXIV, September 7, 2020

Ethnicity and clinical outcomes in COVID-19 A Systematic Review and Meta-analysis
S Sze et al, MEDRXIV, September 8, 2020

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age.
Lieberman Nicole A P et al. PLoS biology 2020 Sep (9) e3000849

We examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA sequencing profiles of nasopharyngeal (NP) swabs from 430 individuals with PCR-confirmed SARS-CoV-2 and 54 negative controls. Our data demonstrate that host responses are dependent on viral load with effects of age and sex that contribute to disease severity.